Gene: RPAP2

79871
C1orf82|Rtr1
RNA polymerase II associated protein 2
protein-coding
1p22.1
Ensembl:ENSG00000122484 MIM:611476 Vega:OTTHUMG00000010288 UniprotKB:Q8IXW5
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.694e-1 (AD)  5.890e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1906279chr1:92350591 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6668685chr1:92326255 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EML50.931
PHLPP20.93
ATG2B0.924
MYO9A0.922
RALGAPB0.921
HERC30.919
TBCK0.918
ZNF5100.917
VPS13A0.913
DNAJC160.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.43
COPZ2-0.43
OR4F5-0.42
CSAG1-0.412
TFPI2-0.411
S100A1-0.403
BCL7C-0.398
NKX6-1-0.398
MDFI-0.397
RBP1-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RPAP2 mRNA"25270620
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RPAP2 mRNA"25614096
D001280AtrazineAtrazine results in decreased expression of RPAP2 mRNA22378314
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RPAP2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RPAP2 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RPAP2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPAP2 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of RPAP2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of RPAP2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of RPAP2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RPAP2 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RPAP2 mRNA27858113
C000944dicrotophosdicrotophos results in decreased expression of RPAP2 mRNA28302478
D005897GlafenineGlafenine results in decreased expression of RPAP2 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of RPAP2 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of RPAP2 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RPAP2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RPAP2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RPAP2 mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RPAP2 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in decreased expression of RPAP2 mRNA24642059
D010936Plant ExtractsPlant Extracts results in increased expression of RPAP2 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPAP2 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RPAP2 mRNA25729387
D014415TunicamycinTunicamycin results in increased expression of RPAP2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of RPAP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RPAP2 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-EXP22137580  
GO:0005515protein binding-IPI24656813  24997600  
GO:0008420CTD phosphatase activity-IBA21873635  
GO:0008420CTD phosphatase activity-IMP22137580  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009301snRNA transcription-IMP22137580  
GO:0042795snRNA transcription by RNA polymerase II-TAS-  
GO:0070940dephosphorylation of RNA polymerase II C-terminal domain-IBA21873635  
GO:0070940dephosphorylation of RNA polymerase II C-terminal domain-IMP22137580  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA22137580  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA22137580  
GO:0005829cytosol-IDA-  
GO:0016591DNA-directed RNA polymerase II, holoenzyme-IDA22137580  22231121  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6807505RNA polymerase II transcribes snRNA genesTAS
R-HSA-6807505RNA polymerase II transcribes snRNA genesIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal