Gene: THSD4

79875
ADAMTSL-6|ADAMTSL6|FVSY9334|PRO34005
thrombospondin type 1 domain containing 4
protein-coding
15q23
Ensembl:ENSG00000187720 MIM:614476 Vega:OTTHUMG00000133389 UniprotKB:Q6ZMP0
NC_000015.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.905e-1 (AD)  9.751e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12102112chr15:71363396 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VWF0.854
SHE0.819
STARD80.813
PTPRB0.807
SLCO2B10.806
BMP60.806
ADCY40.806
PAQR50.787
ABCB10.776
CD340.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.411
SPATA2L-0.377
KCNIP3-0.367
C1orf53-0.366
WNT7A-0.359
HAGHL-0.354
TMEM121-0.352
ZNF771-0.346
FBLL1-0.346
GALNT14-0.345

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of THSD4 mRNA"22101062
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of THSD4 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of THSD4 gene27153756
D001151ArsenicArsenic affects the methylation of THSD4 gene25304211
D001280AtrazineAtrazine results in decreased expression of THSD4 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of THSD4 mRNA21714911
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD4 mRNA27858113
C006780bisphenol Abisphenol A results in increased expression of THSD4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of THSD4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of THSD4 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THSD4 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD4 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of THSD4 mRNA19320972
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of THSD4 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of THSD4 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of THSD4 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of THSD4 mRNA27989131
D002945CisplatinCisplatin results in decreased expression of THSD4 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of THSD4 mRNA26485663
C118739entinostatentinostat results in increased expression of THSD4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD4 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THSD4 mRNA20938992
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of THSD4 mRNA26752646
D008558MelphalanMelphalan results in decreased expression of THSD4 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of THSD4 mRNA20938992
D009532NickelNickel results in decreased expression of THSD4 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of THSD4 mRNA22714537
D010795Phthalic AcidsPhthalic Acids results in decreased expression of THSD4 mRNA21061450
D011374ProgesteroneProgesterone results in increased expression of THSD4 mRNA21273126
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of THSD4 mRNA19167446
D012293RifampinRifampin results in increased expression of THSD4 mRNA24552687
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of THSD4 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of THSD4 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of THSD4 mRNA20133372
D014212TretinoinTretinoin results in increased expression of THSD4 mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of THSD4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of THSD4 mRNA19101580|2800136
D014638VanadatesVanadates results in increased expression of THSD4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of THSD4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008233peptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0048251elastic fiber assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001527microfibril-IEA-  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27564456DNA methylation profiling in human lung tissue identifies genes associated with COPD. (2016 Aug 26)Morrow JDEpigenetics
22461431CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)Hardin MAm J Respir Cell Mol Biol