Gene: RIN3

79890
-
Ras and Rab interactor 3
protein-coding
14q32.12
Ensembl:ENSG00000100599 MIM:610223 Vega:OTTHUMG00000171198 UniprotKB:Q8TB24
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.178e-2 (AD)  6.912e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25066772chr14:93136682RIN34.900e-11Smoking27651444
cg03345232chr14:92981121RIN35.760e-10Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB10.892
CXCL160.886
TNFRSF1B0.864
TNFRSF10B0.86
GPSM30.855
LTBR0.852
SIPA10.848
SPI10.846
RHBDF20.844
STAT5A0.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.535
KCNB2-0.513
PTPRR-0.51
NEUROD6-0.506
MARCH4-0.497
SMIM18-0.496
ABCC12-0.496
SLC7A4-0.495
CALHM1-0.493
B3GALT2-0.486

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RIN3 mRNA"23146750
D000082AcetaminophenAcetaminophen affects the expression of RIN3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RIN3 mRNA21641981
D000638AmiodaroneAmiodarone results in increased expression of RIN3 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RIN3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RIN3 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RIN3 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RIN3 mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of RIN3 mRNA23019147
C006780bisphenol Abisphenol A results in increased methylation of RIN3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of RIN3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RIN3 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RIN3 mRNA22079614
D002737ChloropreneChloroprene results in increased expression of RIN3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RIN3 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of RIN3 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of RIN3 mRNA25562108
C000944dicrotophosdicrotophos results in increased expression of RIN3 mRNA28302478
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of RIN3 gene23968726
D002117CalcitriolCalcitriol results in increased expression of RIN3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of RIN3 mRNA21592394
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RIN3 gene20938992
D005839GentamicinsGentamicins results in increased expression of RIN3 mRNA22061828
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of RIN3 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RIN3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RIN3 mRNA23086925|2429786
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RIN3 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RIN3 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of RIN3 mRNA24449571
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RIN3 mRNA"25926378
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RIN3 mRNA26011545
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of RIN3 mRNA16809437
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RIN3 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RIN3 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RIN3 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RIN3 mRNA23146750
D010795Phthalic AcidsPhthalic Acids results in increased expression of RIN3 mRNA21061450
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of RIN3 gene23968726
D010936Plant ExtractsPlant Extracts results in decreased expression of RIN3 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of RIN3 mRNA24780913
D012999SomanSoman results in increased expression of RIN3 mRNA19281266
D053260SootSoot results in increased expression of RIN3 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of RIN3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of RIN3 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RIN3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RIN3 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RIN3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of RIN3 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RIN3 mRNA25729387
D014520UrethaneUrethane results in decreased expression of RIN3 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of RIN3 mRNA17183730
D014635Valproic AcidValproic Acid results in increased methylation of RIN3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RIN3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IEA-  
GO:0005515protein binding-IPI12972505  17474147  25814554  
GO:0017112Rab guanyl-nucleotide exchange factor activity-IMP21586568  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO:0017137Rab GTPase binding-IDA21586568  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-NAS11733506  
GO:0007165signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IDA21586568  
GO:0005829cytosol-TAS-  
GO:0031410cytoplasmic vesicle-IDA21586568  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget