Gene: PRR5L

79899
PROTOR2
proline rich 5 like
protein-coding
11p13-p12
Ensembl:ENSG00000135362 MIM:611728 Vega:OTTHUMG00000166334 UniprotKB:Q6MZQ0
NC_000011.10
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.032e-1 (AD)  5.865e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11033637chr11:36458239 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2292648chr11:36425819 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12418187chr11:36334692 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02480298chr11:36421230PRR5L3.110e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMCC30.925
FRMD4B0.915
RASGRP30.895
VRK20.893
FAM107B0.878
TMC70.872
C21orf910.869
PLD10.866
RNF1250.865
LAYN0.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.538
PCDH8-0.496
CDH22-0.494
TCERG1L-0.475
MGAT5B-0.466
POU3F1-0.465
HAPLN4-0.458
KCNQ4-0.458
ASB2-0.454
NEUROD1-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRR5L mRNA"19114083
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of PRR5L mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of PRR5L mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRR5L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRR5L mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PRR5L mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PRR5L gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of PRR5L mRNA"23195993
D001151ArsenicArsenic affects the methylation of PRR5L gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PRR5L mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRR5L mRNA21569818
D004958EstradiolEstradiol results in increased expression of PRR5L mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PRR5L mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PRR5L mRNA26079696
D002737ChloropreneChloroprene results in decreased expression of PRR5L mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PRR5L mRNA28472532
D003033Coal TarCoal Tar results in increased expression of PRR5L mRNA27858113
D003471CuprizoneCuprizone results in decreased expression of PRR5L mRNA26577399|2752363
C014347decitabinedecitabine affects the expression of PRR5L mRNA23300844
C007262deoxynivalenoldeoxynivalenol results in decreased expression of PRR5L mRNA26763390
D002945CisplatinCisplatin affects the expression of PRR5L mRNA23300844
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PRR5L mRNA19371625
D002117CalcitriolCalcitriol results in increased expression of PRR5L mRNA16002434
D004237DiuronDiuron results in decreased expression of PRR5L mRNA21551480
D019833GenisteinGenistein results in decreased expression of PRR5L mRNA27539829
D017313FenretinideFenretinide results in increased expression of PRR5L mRNA28973697
C544151jinfukangjinfukang results in increased expression of PRR5L mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRR5L mRNA24796395|2743299
D008694MethamphetamineMethamphetamine results in increased expression of PRR5L mRNA19564919
D008727MethotrexateMethotrexate results in decreased expression of PRR5L mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRR5L mRNA"20188158
D009151Mustard GasMustard Gas affects the expression of PRR5L mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRR5L mRNA"25554681
D009532NickelNickel results in decreased expression of PRR5L mRNA23195993
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PRR5L mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PRR5L mRNA25729387
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of PRR5L mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of PRR5L mRNA28655636
D011441PropylthiouracilPropylthiouracil results in decreased expression of PRR5L mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PRR5L mRNA25895662
D053260SootSoot results in decreased expression of PRR5L mRNA26551751
D013849ThimerosalThimerosal results in decreased expression of PRR5L mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of PRR5L mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRR5L mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PRR5L mRNA25729387
D019772TopotecanTopotecan results in increased expression of PRR5L mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of PRR5L mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of PRR5L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PRR5L mRNA24383497|2800136
D014635Valproic AcidValproic Acid affects the expression of PRR5L mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of PRR5L mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PRR5L mRNA28655636
C029297vinylidene chloridevinylidene chloride results in increased expression of PRR5L mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRR5L mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of PRR5L mRNA26272509
D015032ZincZinc deficiency results in decreased expression of PRR5L mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21964062  
GO:0031625ubiquitin protein ligase binding-IPI22609986  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-IMP22609986  
GO:0001934positive regulation of protein phosphorylation-IEA-  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0010762regulation of fibroblast migration-IMP22609986  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0034599cellular response to oxidative stress-IMP21964062  
GO:0038203TORC2 signaling-IBA21873635  
GO:0038203TORC2 signaling-IDA22609986  
GO:0061014positive regulation of mRNA catabolic process-IMP21964062  
GO:0090316positive regulation of intracellular protein transport-IMP21964062  
GO ID GO Term Qualifier Evidence PubMed
GO:0031932TORC2 complex-IBA21873635  
GO:0031932TORC2 complex-IDA22609986  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal