Gene: TUSC3

7991
D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A
tumor suppressor candidate 3
protein-coding
8p22
Ensembl:ENSG00000104723 MIM:601385 Vega:OTTHUMG00000094803 UniprotKB:Q13454
NG_012141.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.587e-1 (AD)  4.153e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REEP10.963
ELMOD10.961
CD2000.96
GPRASP20.957
ITFG10.954
SYT40.953
SLC25A140.953
PGM2L10.95
HSDL10.95
NSF0.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.549
RNF135-0.517
MAGEA12-0.513
REST-0.497
SYDE1-0.492
RUNX3-0.485
CHST14-0.484
CXCR2-0.479
YES1-0.479
ASB4-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of TUSC3 mRNA20566314
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TUSC3 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TUSC3 mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of TUSC3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TUSC3 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TUSC3 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TUSC3 mRNA23630614
D000638AmiodaroneAmiodarone results in increased expression of TUSC3 mRNA19774075
D001151ArsenicArsenic affects the methylation of TUSC3 gene25304211
D001379AzathioprineAzathioprine results in increased expression of TUSC3 mRNA22623647
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of TUSC3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TUSC3 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TUSC3 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TUSC3 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of TUSC3 mRNA27104808
C006780bisphenol Abisphenol A results in increased expression of TUSC3 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TUSC3 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TUSC3 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUSC3 gene20938992
C031180chrysenechrysene results in decreased expression of TUSC3 mRNA26377693
D019327Copper SulfateCopper Sulfate results in increased expression of TUSC3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TUSC3 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of TUSC3 mRNA20106945|2556210
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of TUSC3 mRNA]21095227
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TUSC3 mRNA]27941970
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TUSC3 mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TUSC3 mRNA25380136
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TUSC3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TUSC3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC3 mRNA17942748
C082360fipronilfipronil results in increased expression of TUSC3 mRNA23962444
C007738fluoranthene[fluoranthene co-treated with pyrene] results in decreased expression of TUSC3 mRNA20117838
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUSC3 gene20938992
C039281furanfuran results in increased expression of TUSC3 mRNA25539665|2619464
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of TUSC3 mRNA20566314
D017313FenretinideFenretinide results in increased expression of TUSC3 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of TUSC3 mRNA21396975
D048628KetolidesKetolides analog results in increased expression of TUSC3 mRNA24967691
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUSC3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TUSC3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TUSC3 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TUSC3 mRNA26924002
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TUSC3 mRNA25380136
D010634PhenobarbitalPhenobarbital affects the expression of TUSC3 mRNA19136022
D010634PhenobarbitalPhenobarbital results in increased expression of TUSC3 mRNA19270015
C006253pirinixic acidpirinixic acid affects the expression of TUSC3 mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of TUSC3 mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of TUSC3 mRNA22484513
D011441PropylthiouracilPropylthiouracil results in increased expression of TUSC3 mRNA24780913
C030984pyrene[fluoranthene co-treated with pyrene] results in decreased expression of TUSC3 mRNA20117838
D011794QuercetinQuercetin results in increased expression of TUSC3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TUSC3 mRNA23806026
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of TUSC3 mRNA]21095227
C009277sodium arsenatesodium arsenate results in increased expression of TUSC3 mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of TUSC3 gene28589171
C016104sodium bichromatesodium bichromate results in increased expression of TUSC3 mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of TUSC3 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of TUSC3 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TUSC3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TUSC3 mRNA21215274
D013806TheophyllineTheophylline results in increased expression of TUSC3 mRNA16083514
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TUSC3 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of TUSC3 mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of TUSC3 mRNA15901671
D014520UrethaneUrethane results in increased expression of TUSC3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of TUSC3 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of TUSC3 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of TUSC3 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004579dolichyl-diphosphooligosaccharide-protein glycotransferase activityCONTRIBUTES_TOIBA21873635  
GO:0004579dolichyl-diphosphooligosaccharide-protein glycotransferase activitycontributes_toISS-  
GO:0015095magnesium ion transmembrane transporter activity-IMP19717468  
GO:0015095magnesium ion transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006487protein N-linked glycosylation-NAS18455129  
GO:0015693magnesium ion transport-IMP19717468  
GO:0018279protein N-linked glycosylation via asparagine-IBA21873635  
GO:0018279protein N-linked glycosylation via asparagine-IMP26864433  
GO:0018279protein N-linked glycosylation via asparagine-ISS-  
GO:0050890cognition-IMP18455129  
GO:0055085transmembrane transport-TAS-  
GO:1903830magnesium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-ISS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS19717468  
GO:0008250oligosaccharyltransferase complex-IBA21873635  
GO:0008250oligosaccharyltransferase complex-IDA15835887  
KEGG ID KEGG Term
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5223345Miscellaneous transport and binding eventsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22447362Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. (2012 Dec 1)Yuasa YInt J Cancer