Gene info: ID 79923

Gene: NANOG

GENE ID: 79923

Synonyms: -

Description: Nanog homeobox

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000111704 MIM:607937 Vega:OTTHUMG00000166019 UniprotKB:Q9H9S0

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.702e-1 (AD) 5.554e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR9Q2	0.744
MTRNR2L5	0.74
TAS2R41	0.739
PRDM14	0.73
TMEM247	0.729
OR56A4	0.723
PRAMEF17	0.718
OR10K1	0.715
CD1B	0.713
TAS2R30	0.71

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CLDND2	-0.27
CLEC11A	-0.239
CCL27	-0.237
HDDC3	-0.236
RILP	-0.233
VPREB3	-0.228
YBX2	-0.227
SURF2	-0.224
RWDD4	-0.217
CCDC175	-0.216

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of NANOG protein	23143138
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NANOG protein	23143138
C022830	2-methoxyestradiol	2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]	25822711
C012587	3,5,6-trichloro-2-pyridinol	"3,5,6-trichloro-2-pyridinol results in decreased expression of NANOG mRNA"	23220036
C025946	3-methyladenine	3-methyladenine results in increased expression of NANOG mRNA	21681844
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C555021	4-acetylantroquinonol B	4-acetylantroquinonol B results in decreased expression of NANOG protein	26235807
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C501332	ABT-737	ABT-737 results in decreased expression of NANOG protein	23918355
D019342	Acetic Acid	Acetic Acid results in decreased expression of NANOG protein	21296659
D020106	Acrylamide	Acrylamide results in decreased expression of NANOG mRNA	28959563
C016601	afimoxifene	afimoxifene results in increased expression of NANOG protein	27581495
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of NANOG protein	23936228
D013196	Dihydrotestosterone	SHBG affects the reaction [Dihydrotestosterone results in increased expression of NANOG protein]	23936228
D047310	Apigenin	Apigenin results in decreased expression of NANOG protein	27468969
C487081	belinostat	belinostat results in increased expression of NANOG mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NANOG mRNA	22316170
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of NANOG protein]	23651583
D004958	Estradiol	Estradiol results in increased expression of NANOG protein	23391485
C006780	bisphenol A	bisphenol A results in increased expression of NANOG mRNA	24424067
C006780	bisphenol A	bisphenol A results in increased expression of NANOG protein	23391485
C006780	bisphenol A	bisphenol A results in increased expression of NANOG protein	24090592
C006780	bisphenol A	bisphenol A results in decreased expression of NANOG mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of NANOG protein	24134786
C006780	bisphenol A	bisphenol A results in decreased expression of NANOG mRNA	28819136
C099813	bromochloroacetic acid	bromochloroacetic acid results in increased expression of NANOG protein	21296659
C018475	butyraldehyde	butyraldehyde results in decreased expression of NANOG mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of NANOG protein	20201064
D002104	Cadmium	Cadmium results in decreased expression of NANOG mRNA	24376830
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NANOG mRNA	24763279
C473710	Chir 98014	Chir 98014 results in decreased expression of NANOG mRNA	22723015
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of NANOG mRNA	21356183
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in decreased expression of NANOG mRNA	21356183
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of NANOG mRNA	23220036
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of NANOG mRNA	19654923
C074702	chromium hexavalent ion	MAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased expression of NANOG mRNA]	19654923
D002939	Ciprofloxacin	Ciprofloxacin results in increased expression of NANOG protein	26947806
C018021	cobaltous chloride	[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of NANOG mRNA	25805230
C018021	cobaltous chloride	[HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of NANOG mRNA	25805230
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in decreased expression of NANOG mRNA	21356183
D003300	Copper	Copper results in decreased expression of NANOG mRNA	21356183
D003474	Curcumin	2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]	25822711
D003474	Curcumin	Curcumin results in increased expression of NANOG mRNA	25822711\|2723778
D003474	Curcumin	Curcumin results in increased expression of NANOG protein	25822711
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of NANOG mRNA	26206603
C014347	decitabine	decitabine results in decreased expression of NANOG mRNA	23300844
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of NANOG mRNA	27151938
D016190	Carboplatin	Carboplatin results in increased expression of NANOG mRNA	25605917
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of NANOG mRNA	20705681
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of NANOG protein	20705681
D002945	Cisplatin	Cisplatin results in decreased expression of NANOG mRNA	23300844
D002945	Cisplatin	[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of NANOG mRNA	21342274
D002945	Cisplatin	[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of NANOG protein	21342274
D002945	Cisplatin	Cisplatin results in increased expression of NANOG mRNA	21618587
D002945	Cisplatin	Cisplatin results in increased expression of NANOG protein	21618587
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of NANOG mRNA	28286118
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of NANOG mRNA"	27840820
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of NANOG mRNA	22105179
C118739	entinostat	entinostat results in increased expression of NANOG mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of NANOG mRNA	28189721
D005472	Fluorouracil	Fluorouracil affects the expression of NANOG protein	21296659
C070081	fulvestrant	fulvestrant results in increased expression of NANOG protein	27581495
C039281	furan	furan results in decreased expression of NANOG mRNA	25539665
C056507	gemcitabine	gemcitabine results in decreased expression of NANOG mRNA	25605917
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of NANOG mRNA	22634610
C071834	glycidamide	glycidamide affects the expression of NANOG protein	21978862
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NANOG mRNA	24763279
C519562	imetelstat	imetelstat results in decreased expression of NANOG mRNA	20824134
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NANOG mRNA	24796395\|2683047
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NANOG protein	26067464
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NANOG mRNA	25393219
C006552	kaempferol	kaempferol results in increased expression of NANOG protein	26683311
C008261	lead acetate	lead acetate results in decreased expression of NANOG mRNA	25270620
D008070	Lipopolysaccharides	NANOG inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]	22200792
D008070	Lipopolysaccharides	NANOG inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]	22200792
D008070	Lipopolysaccharides	NANOG inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	22200792
D008070	Lipopolysaccharides	NANOG inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	22200792
D008070	Lipopolysaccharides	NANOG inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	22200792
D008070	Lipopolysaccharides	NANOG inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]	22200792
D018021	Lithium Chloride	Lithium Chloride results in increased expression of NANOG mRNA	20069066
D018021	Lithium Chloride	SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of NANOG mRNA]	20069066
C010480	lupeol	lupeol results in decreased expression of NANOG protein	20979057
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of NANOG mRNA	22555245\|2390381
C015358	methylparaben	methylparaben results in increased expression of NANOG mRNA	27581495
C015358	methylparaben	methylparaben results in increased expression of NANOG protein	27581495
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NANOG mRNA]"	19615344
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate results in increased expression of NANOG mRNA"	19615344
C000621033	napabucasin	napabucasin results in decreased expression of NANOG mRNA	25605917\|2689996
C000621033	napabucasin	napabucasin results in decreased expression of NANOG protein	25605917\|2689996
C005273	naringenin	naringenin results in decreased expression of NANOG protein	27468969
D009538	Nicotine	Nicotine results in increased expression of NANOG mRNA	23219715
D009538	Nicotine	Nicotine results in increased expression of NANOG protein	23219715
D009538	Nicotine	SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]	23219715
C047330	N-methylisoindigotin	N-methylisoindigotin results in decreased expression of NANOG protein	26887594
D015739	Nocodazole	Nocodazole results in decreased expression of NANOG protein	21559451
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of NANOG mRNA"	23220036
D010100	Oxygen	Oxygen deficiency promotes the reaction [LIF protein affects the reaction NANOG mRNA]	26723917
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of NANOG mRNA	20705681
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of NANOG protein	20705681
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of NANOG mRNA	26272509
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of NANOG mRNA	24642059
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of NANOG protein	27153767
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of NANOG mRNA	24098361
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of NANOG protein	24098361
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of NANOG mRNA	25510869
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of NANOG protein	25510869
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of NANOG protein	27153767
C006253	pirinixic acid	pirinixic acid results in decreased expression of NANOG mRNA	25270620
D011794	Quercetin	Quercetin results in decreased expression of NANOG protein	22422628\|2391835
C059514	resveratrol	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of NANOG protein]	23651583
C059514	resveratrol	NANOG protein results in decreased susceptibility to resveratrol	21304978
C059514	resveratrol	resveratrol results in decreased expression of NANOG mRNA	21304978\|2269295
C059514	resveratrol	resveratrol results in decreased expression of NANOG protein	22692956\|2365158
C059514	resveratrol	TP53 mutant form inhibits the reaction [resveratrol results in decreased expression of NANOG protein]	23651583
D020123	Sirolimus	Sirolimus results in increased expression of NANOG mRNA	21681844
C017947	sodium arsenite	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NANOG mRNA]"	19615344
C017947	sodium arsenite	sodium arsenite results in decreased expression of NANOG mRNA	19615344
C017947	sodium arsenite	sodium arsenite results in decreased expression of NANOG protein	23219847
C017947	sodium arsenite	sodium arsenite results in increased expression of NANOG mRNA	24431212
C017947	sodium arsenite	[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of NANOG protein	23143138
C017947	sodium arsenite	[OGG1 gene mutant form results in increased susceptibility to sodium arsenite] which affects the expression of NANOG mRNA	26438402
C017947	sodium arsenite	sodium arsenite results in decreased expression of NANOG protein	23143138\|2321984
C017947	sodium arsenite	sodium arsenite results in increased expression of NANOG mRNA	22641621\|2643840
C017947	sodium arsenite	sodium arsenite results in increased expression of NANOG protein	22641621
C032706	sodium chlorate	sodium chlorate results in increased expression of NANOG mRNA	19937756
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of NANOG mRNA	18175754
C105686	SU 5402	SU 5402 results in increased expression of NANOG mRNA	19937756
C473478	sunitinib	sunitinib results in increased expression of NANOG mRNA	25605917
C021751	tanshinone	tanshinone results in increased expression of NANOG mRNA	25186638
D013656	Taurocholic Acid	Taurocholic Acid results in increased expression of NANOG mRNA	27151938
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NANOG mRNA	24058054
D013792	Thalidomide	Thalidomide results in decreased expression of NANOG mRNA	26217789
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of NANOG mRNA	27237783
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of NANOG mRNA	27237783
D014212	Tretinoin	Tretinoin results in decreased expression of NANOG mRNA	16168501\|1713896
D014212	Tretinoin	NR6A1 protein affects the reaction [Tretinoin results in decreased expression of NANOG mRNA]	16166633
D014212	Tretinoin	Tretinoin results in decreased expression of NANOG mRNA	22466603
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of NANOG mRNA	22723015\|2493525
D014260	Triclosan	Triclosan results in increased expression of NANOG mRNA	24879426
D014260	Triclosan	Triclosan results in decreased expression of NANOG mRNA	24879426
D014260	Triclosan	Triclosan results in decreased expression of NANOG protein	24879426
D014520	Urethane	Urethane results in decreased expression of NANOG mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of NANOG mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased expression of NANOG mRNA	22723015\|2317975
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of NANOG gene	25560391
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NANOG mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of NANOG mRNA	27188386
C111237	vorinostat	vorinostat results in increased expression of NANOG mRNA	26272509
D015032	Zinc	Zinc deficiency results in increased expression of NANOG mRNA	20932299

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	23708658
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IC	-
GO:0003677	DNA binding	-	IDA	16153702 19427902
GO:0003700	DNA-binding transcription factor activity	-	IDA	16153702
GO:0003714	transcription corepressor activity	-	ISS	-
GO:0005515	protein binding	-	IPI	26687479
GO:0044212	transcription regulatory region DNA binding	-	IDA	25825768

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001714	endodermal cell fate specification	-	IDA	20713518
GO:0006355	regulation of transcription, DNA-templated	-	IDA	16153702
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0008283	cell proliferation	-	IMP	16501172
GO:0010468	regulation of gene expression	-	IMP	18388306
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0019827	stem cell population maintenance	-	IEP	15108323
GO:0019827	stem cell population maintenance	-	ISS	-
GO:0030154	cell differentiation	-	IEP	16501172
GO:0035019	somatic stem cell population maintenance	-	IMP	18388306
GO:0035019	somatic stem cell population maintenance	-	TAS	-
GO:0045595	regulation of cell differentiation	-	IMP	16501172
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	20713518
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IC	16153702
GO:0005634	nucleus	-	IDA	18932205
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IDA	20458727

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	TAS
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23876628	Relevance of cancer initiating/stem cells in carcinogenesis and therapy resistance in oral cancer. (2013 Sep)	Sinha N	Oral Oncol
29416638	Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice. (2018 Jan 2)	Li T	Oncotarget
29256636	Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells. (2017 Dec 19)	Machida K	Antioxid Redox Signal
29540668	Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway. (2018 Mar 13)	Qian W	Oncogenesis
29033581	NANOG as an adverse predictive marker in advanced non-small cell lung cancer treated with platinum-based chemotherapy. (2017)	Chang B	Onco Targets Ther
26518146	Tumorigenesis of smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is related to its ability to stimulate thromboxane synthase and enhance stemness of non-small cell lung cancer stem cells. (2016 Jan 28)	Liu Y	Cancer Lett