Gene: CNTD2

79935
CCNP
cyclin N-terminal domain containing 2
protein-coding
19q13.2
Ensembl:ENSG00000105219 Vega:OTTHUMG00000160481 UniprotKB:Q9H8S5
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.229e-1 (AD)  5.995e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11866303chr19:40732691CNTD2Promoter4.982e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR90.774
KLK140.722
CCNA20.718
RAX20.714
NPC1L10.707
DNASE1L20.706
SLFNL10.7
FGFR40.7
SIRT70.699
TCAP0.69

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTSO-0.386
TMEM220-0.33
HSD17B8-0.323
SRBD1-0.32
HMGB3-0.319
RBM3-0.318
PBLD-0.317
TTC30A-0.317
DPH6-0.314
CNGA1-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of CNTD2 mRNA25929836
C544151jinfukangjinfukang results in decreased expression of CNTD2 mRNA27392435
D010936Plant ExtractsPlant Extracts results in decreased expression of CNTD2 mRNA23557933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activityCONTRIBUTES_TOIBA21873635  
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-IBA21873635  
GO:0019901protein kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0007088regulation of mitotic nuclear division-IBA21873635  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0045787positive regulation of cell cycle-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25482056Fetal lung and placental methylation is associated with in utero nicotine exposure. (2014 Nov)Chhabra DEpigenetics