Gene: PDZD7

79955
DFNB57|PDZK7
PDZ domain containing 7
protein-coding
10q24.31
Ensembl:ENSG00000186862 MIM:612971 Vega:OTTHUMG00000018916 UniprotKB:Q9H5P4
NG_028030.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.558e-2 (AD)  1.105e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs701837chr10:101015448 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05593775chr10:102778743PDZD74.640e-12Maternal smoking in pregnancy27040690
cg05593775chr10:102778743PDZD72.990e-16Maternal smoking in pregnancy27040690
cg14585415chr10:102778683PDZD71.500e-9Maternal smoking in pregnancy27040690
cg21378403chr10:102777924PDZD73.390e-8Maternal smoking in pregnancy27040690
cg05593775chr10:102778743PDZD74.310e-19Maternal smoking in pregnancy27040690
cg14585415chr10:102778683PDZD72.190e-10Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP3B20.914
SPTBN40.908
RELL20.907
TRIM30.905
LPCAT40.903
TRPM20.9
SYT70.9
ACTL6B0.899
DGKQ0.896
GGT70.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.582
YES1-0.576
NXT2-0.541
RAI14-0.54
WWTR1-0.539
MBNL3-0.515
CNN2-0.515
MAML2-0.513
GNG12-0.51
PRKD3-0.506

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDZD7 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PDZD7 mRNA"20816883
D000082AcetaminophenAcetaminophen results in increased expression of PDZD7 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PDZD7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PDZD7 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of PDZD7 mRNA20458559
C006780bisphenol Abisphenol A results in decreased expression of PDZD7 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of PDZD7 mRNA26079696
C480342clothianidinclothianidin results in decreased expression of PDZD7 mRNA29044138
D019327Copper SulfateCopper Sulfate results in increased expression of PDZD7 mRNA19549813
C000944dicrotophosdicrotophos results in increased expression of PDZD7 mRNA28302478
C069837fullerene C60fullerene C60 results in decreased expression of PDZD7 mRNA19167457
C039281furanfuran results in decreased expression of PDZD7 mRNA25539665
C544151jinfukangjinfukang results in increased expression of PDZD7 mRNA27392435
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of PDZD7 mRNA27188386
C028007nickel monoxidenickel monoxide results in decreased expression of PDZD7 mRNA19167457
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of PDZD7 mRNA23602845
C006253pirinixic acidpirinixic acid results in decreased expression of PDZD7 mRNA20813756
C005556propionaldehydepropionaldehyde results in increased expression of PDZD7 mRNA26079696
D012715Sesame OilSesame Oil results in increased expression of PDZD7 mRNA29191790
D014520UrethaneUrethane results in decreased expression of PDZD7 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of PDZD7 mRNA23527032
D014635Valproic AcidValproic Acid results in increased methylation of PDZD7 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19028668  20440071  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007605sensory perception of sound-IBA21873635  
GO:0042472inner ear morphogenesis-IBA21873635  
GO:0042491inner ear auditory receptor cell differentiation-IBA21873635  
GO:0045184establishment of protein localization-IEA-  
GO:0050910detection of mechanical stimulus involved in sensory perception of sound-IEA-  
GO:0060088auditory receptor cell stereocilium organization-IBA21873635  
GO:0060088auditory receptor cell stereocilium organization-IEA-  
GO:0060119inner ear receptor cell development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segmentCOLOCALIZES_WITHIBA21873635  
GO:0002141stereocilia ankle link-IBA21873635  
GO:0002141stereocilia ankle link-IEA-  
GO:0002142stereocilia ankle link complex-IBA21873635  
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-IDA20440071  
GO:0005886plasma membrane-IBA21873635  
GO:0005929cilium-IDA20440071  
GO:0032391photoreceptor connecting ciliumCOLOCALIZES_WITHIBA21873635  
GO:0032420stereocilium-IBA21873635  
GO:0032426stereocilium tip-IBA21873635  
GO:1990696USH2 complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal