Gene: SCD5

79966
ACOD4|FADS4|HSCD5|SCD2|SCD4
stearoyl-CoA desaturase 5
protein-coding
4q21.22
Ensembl:ENSG00000145284 MIM:608370 Vega:OTTHUMG00000130293 UniprotKB:Q86SK9
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.042e-1 (AD)  1.804e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12500169chr4:82723573 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPM6B0.913
TMBIM60.907
TSPAN30.902
TMEM9B0.9
CPE0.899
EMC100.898
NAP1L40.898
ENO10.897
CADM40.895
PPP2CB0.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.884
OR4F29-0.862
FER1L6-0.209
CLEC6A-0.203
GADL1-0.202
C2orf83-0.199
IFNG-0.189
DPPA4-0.186
OR51A7-0.18
KRT73-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCD5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCD5 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SCD5 mRNA24449571
C015001arsenitearsenite results in increased methylation of SCD5 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCD5 mRNA23178640
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SCD5 mRNA"19150397
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SCD5 mRNA23178640
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SCD5 mRNA20971185
D003703DemecolcineDemecolcine results in increased expression of SCD5 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of SCD5 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SCD5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SCD5 mRNA27392435
D005557FormaldehydeFormaldehyde results in increased expression of SCD5 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SCD5 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SCD5 mRNA23179753
D009532NickelNickel results in decreased expression of SCD5 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SCD5 mRNA20971185
D010261ParaoxonParaoxon results in increased expression of SCD5 mRNA24413757
D010416PentachlorophenolPentachlorophenol results in decreased expression of SCD5 mRNA23178640
D011374ProgesteroneProgesterone results in decreased expression of SCD5 mRNA23018184
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SCD5 mRNA25895662
D014212TretinoinTretinoin results in decreased expression of SCD5 mRNA21934132
D014212TretinoinTretinoin results in increased expression of SCD5 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCD5 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of SCD5 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of SCD5 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of SCD5 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of SCD5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SCD5 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SCD5 mRNA23179753|2493525
D014638VanadatesVanadates results in increased expression of SCD5 mRNA22714537
D014750VincristineVincristine results in increased expression of SCD5 mRNA23649840
C088658zoledronic acidzoledronic acid results in decreased expression of SCD5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004768stearoyl-CoA 9-desaturase activity-EXP15610069  15907797  
GO:0004768stearoyl-CoA 9-desaturase activity-IBA21873635  
GO:0004768stearoyl-CoA 9-desaturase activity-IDA15907797  
GO:0005506iron ion binding-IBA21873635  
GO:0016491oxidoreductase activity-IDA15907797  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006636unsaturated fatty acid biosynthetic process-IDA15907797  
GO:0046949fatty-acyl-CoA biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO:1903966monounsaturated fatty acid biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IDA15907797  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa01040Biosynthesis of unsaturated fatty acids
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal