Gene: WLS

79971
C1orf139|EVI|GPR177|MRP|mig-14
wntless Wnt ligand secretion mediator
protein-coding
1p31.3
Ensembl:ENSG00000116729 MIM:611514 Vega:OTTHUMG00000009153 UniprotKB:Q5T9L3
NC_000001.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.644e-1 (AD)  9.557e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AHCYL10.909
PBXIP10.895
PITPNC10.893
MAOA0.892
PLCD10.891
AGT0.891
FERMT20.888
NPAS30.887
METTL7A0.886
DHTKD10.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.485
OR4F29-0.454
ABCC12-0.349
DUSP27-0.343
RTP1-0.337
TYRP1-0.337
CALHM1-0.334
AGMAT-0.333
ADRA1D-0.329
PPEF1-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of WLS mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of WLS mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of WLS gene27153756
D001151ArsenicArsenic affects the methylation of WLS gene25304211
D001280AtrazineAtrazine results in increased expression of WLS mRNA22378314
D001280AtrazineAtrazine results in increased expression of WLS mRNA27614199
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WLS mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of WLS mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of WLS mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of WLS gene22576693
C006780bisphenol Abisphenol A affects the expression of WLS mRNA21786754
C006780bisphenol Abisphenol A affects the expression of WLS mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of WLS mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of WLS mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WLS mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of WLS mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of WLS mRNA19376846
D003471CuprizoneCuprizone results in increased expression of WLS mRNA26577399
C014347decitabinedecitabine affects the expression of WLS mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of WLS mRNA21266533
D002945CisplatinCisplatin affects the expression of WLS mRNA23300844
D002945CisplatinCisplatin results in decreased expression of WLS mRNA22023808
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of WLS mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of WLS mRNA25380136
C118739entinostatentinostat results in increased expression of WLS mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WLS mRNA26865667
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WLS mRNA20938992
C039281furanfuran results in increased expression of WLS mRNA27387713
D019833GenisteinGenistein affects the expression of WLS mRNA26865667
C492448ICG 001ICG 001 results in decreased expression of WLS mRNA26191083
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WLS mRNA20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of WLS mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of WLS mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of WLS mRNA24810058
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of WLS mRNA24128854
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of WLS mRNA25380136
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of WLS mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
D010634PhenobarbitalPhenobarbital affects the expression of WLS mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of WLS mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of WLS mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WLS mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of WLS mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of WLS mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of WLS mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of WLS mRNA27029645
D012715Sesame OilSesame Oil results in decreased expression of WLS mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of WLS mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of WLS gene28589171
D012999SomanSoman results in increased expression of WLS mRNA19281266
D014284TriiodothyronineTriiodothyronine results in increased expression of WLS mRNA23397585
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WLS mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WLS mRNA21570461
D013893ThiramThiram results in increased expression of WLS mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of WLS mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of WLS mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of WLS mRNA25729387
D014212TretinoinTretinoin results in increased expression of WLS mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of WLS mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WLS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of WLS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of WLS gene29154799
D014635Valproic AcidValproic Acid results in increased expression of WLS mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of WLS gene25560391
C025643vinclozolinvinclozolin results in increased expression of WLS mRNA22570695
D014810Vitamin EVitamin E results in increased expression of WLS mRNA19244175
C088658zoledronic acidzoledronic acid results in decreased expression of WLS mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18160348  20214800  23840749  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0017147Wnt-protein binding-IPI24768165  
GO:0017147Wnt-protein binding-ISS16678095  
GO:0031852mu-type opioid receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001707mesoderm formation-IEA-  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006886intracellular protein transport-IMP16678095  
GO:0009948anterior/posterior axis specification-ISS-  
GO:0016055Wnt signaling pathway-ISS-  
GO:0016055Wnt signaling pathway-TAS-  
GO:0030177positive regulation of Wnt signaling pathway-IMP16678095  16678096  
GO:0030901midbrain development-IEA-  
GO:0030902hindbrain development-IEA-  
GO:0031017exocrine pancreas development-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-ISS-  
GO:0061355Wnt protein secretion-IBA21873635  
GO:0061355Wnt protein secretion-IMP24768165  
GO:0061357positive regulation of Wnt protein secretion-IMP16678095  
GO:0061357positive regulation of Wnt protein secretion-ISS16678096  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP17804805  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005769early endosome-IDA18160348  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IDA16678095  
GO:0005802trans-Golgi network-IDA18160348  
GO:0005886plasma membrane-IDA18160348  
GO:0005886plasma membrane-TAS-  
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0031301integral component of organelle membrane-IBA21873635  
GO:0031410cytoplasmic vesicle-IDA16678095  
GO:0031901early endosome membrane-TAS-  
GO:0032590dendrite membrane-IEA-  
GO:0032839dendrite cytoplasm-IEA-  
GO:0070062extracellular exosome-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-3238698WNT ligand biogenesis and traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24333843Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. (2014 Apr 3)Jaremko KMProg Neuropsychopharmacol Biol Psychiatry
22001156Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. (2012 Jan)Reyes BAExp Neurol
23566366Case-control association study of WLS variants in opioid and cocaine addicted populations. (2013 Jun 30)Crist RCPsychiatry Res