Gene: GRHL2

79977
BOM|DFNA28|ECTDS|TFCP2L3
grainyhead like transcription factor 2
protein-coding
8q22.3
Ensembl:ENSG00000083307 MIM:608576 Vega:OTTHUMG00000149915 UniprotKB:Q6ISB3
NG_011971.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.718e-1 (AD)  5.165e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16867971chr8:101597228 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03273057chr8:102533612GRHL25.260e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM86B0.44
SLC22A120.416
CRYBB20.404
SOHLH10.394
CCDC840.394
SDIM10.384
CRYGS0.365
FAM83C0.359
FAM72C0.357
TRIM540.351

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIST1H2AK-0.354
PCDHA4-0.345
RAB23-0.344
RNASEH1-0.341
PCDHA10-0.335
TRIM44-0.331
ZNF322-0.328
CYB5RL-0.327
TBC1D14-0.321
KRBA2-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of GRHL2 mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GRHL2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C496492abrineabrine results in decreased expression of GRHL2 mRNA22595364
D001280AtrazineAtrazine results in increased expression of GRHL2 mRNA25929836
C006780bisphenol Abisphenol A affects the methylation of GRHL2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of GRHL2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of GRHL2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRHL2 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of GRHL2 mRNA25979313
D003300CopperCopper deficiency results in increased expression of GRHL2 mRNA26033743
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA16931933
D002117CalcitriolCalcitriol results in increased expression of GRHL2 mRNA26485663
D017313FenretinideFenretinide results in increased expression of GRHL2 mRNA28973697
C042720mercuric bromidemercuric bromide results in increased expression of GRHL2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GRHL2 mRNA"25554681
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GRHL2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of GRHL2 mRNA20813756
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GRHL2 mRNA23806026
D012906SmokeSmoke results in decreased expression of GRHL2 mRNA21095227
C017947sodium arsenitesodium arsenite affects the expression of GRHL2 mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRHL2 mRNA21570461|2405805
C009495titanium dioxidetitanium dioxide results in increased expression of GRHL2 mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GRHL2 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRHL2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GRHL2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GRHL2 mRNA23179753|2438349
C029297vinylidene chloridevinylidene chloride results in decreased expression of GRHL2 mRNA26682919
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001161intronic transcription regulatory region sequence-specific DNA binding-ISS-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA23814079  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP29309642  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI25416956  
GO:0031490chromatin DNA binding-IDA21081122  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA19015635  20938050  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-ISS-  
GO:0003208cardiac ventricle morphogenesis-IEA-  
GO:0003382epithelial cell morphogenesis-IMP25152456  
GO:0003382epithelial cell morphogenesis-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007155cell adhesion-IMP25152456  
GO:0007420brain development-IBA21873635  
GO:0008283cell proliferation-IMP20938050  
GO:0008544epidermis development-IDA23254293  
GO:0021915neural tube development-IBA21873635  
GO:0034329cell junction assembly-IMP25152456  
GO:0035264multicellular organism growth-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0043010camera-type eye development-IEA-  
GO:0044030regulation of DNA methylation-IDA23254293  
GO:0044030regulation of DNA methylation-IMP20938050  
GO:0045617negative regulation of keratinocyte differentiation-IDA23254293  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA23814079  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP29309642  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO:0051973positive regulation of telomerase activity-IMP19015635  20938050  
GO:0060324face development-IEA-  
GO:0060463lung lobe morphogenesis-IEA-  
GO:0060487lung epithelial cell differentiation-ISS-  
GO:0060672epithelial cell morphogenesis involved in placental branching-IEA-  
GO:0070830bicellular tight junction assembly-IMP25152456  
GO:0090132epithelium migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20938050  21081122  23814079  25152456  
GO:0005654nucleoplasm-IDA-  
GO:0005911cell-cell junction-IDA25152456  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26400775Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study. (2015 Sep 24)Zhang XEnviron Health
27318899[Association between grainyhead-like 2 gene polymorphisms and noise-induced hearing loss]. (2016 Jun 18)Yang QYBeijing Da Xue Xue Bao Yi Xue Ban