Gene: ELOVL7

79993
-
ELOVL fatty acid elongase 7
protein-coding
5q12.1
Ensembl:ENSG00000164181 MIM:614451 Vega:OTTHUMG00000162254 UniprotKB:A1L3X0
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.880e-1 (AD)  5.055e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGA10.91
ACSL50.864
MAP3K80.863
CFH0.863
ERG0.859
PAPSS20.857
IL13RA10.854
IRAK30.854
VWF0.854
TGM20.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.534
WNT7A-0.529
MARCH4-0.514
CPLX3-0.507
KCNG1-0.495
HAS1-0.494
CORT-0.491
ASPDH-0.489
TMEM121-0.489
GSG1-0.485

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ELOVL7 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ELOVL7 mRNA"19167446
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of ELOVL7 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELOVL7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELOVL7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ELOVL7 mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ELOVL7 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ELOVL7 mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ELOVL7 mRNA24449571
D001280AtrazineAtrazine results in increased expression of ELOVL7 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ELOVL7 mRNA21802500
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ELOVL7 mRNA19770486|2719552
C006780bisphenol Abisphenol A results in decreased expression of ELOVL7 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ELOVL7 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ELOVL7 mRNA20938992
D002857ChromiumChromium results in increased expression of ELOVL7 mRNA21437242
D003300CopperCopper deficiency results in increased expression of ELOVL7 mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ELOVL7 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ELOVL7 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ELOVL7 mRNA19167446
D003471CuprizoneCuprizone affects the expression of ELOVL7 mRNA26577399
D003471CuprizoneCuprizone results in decreased expression of ELOVL7 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ELOVL7 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of ELOVL7 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of ELOVL7 mRNA19770486
D004026DieldrinDieldrin results in increased expression of ELOVL7 mRNA23153324
D019422Dietary SucroseDietary Sucrose results in increased expression of ELOVL7 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ELOVL7 mRNA24535843
D005485FlutamideFlutamide results in decreased expression of ELOVL7 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ELOVL7 mRNA20938992
C039281furanfuran results in increased expression of ELOVL7 mRNA25539665
D006533HeptachlorHeptachlor results in increased expression of ELOVL7 mRNA23153324
C544151jinfukangjinfukang results in decreased expression of ELOVL7 mRNA27392435
C410337K 7174K 7174 results in increased expression of ELOVL7 mRNA24086573
D008055LipidsELOVL7 protein affects the metabolism of Lipids20035504
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ELOVL7 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ELOVL7 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ELOVL7 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ELOVL7 mRNA22776087
D008917MirexMirex results in increased expression of ELOVL7 mRNA23153324
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ELOVL7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ELOVL7 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of ELOVL7 mRNA22714537
C464660obeticholic acidobeticholic acid results in increased expression of ELOVL7 mRNA27939613
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELOVL7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ELOVL7 mRNA26272509
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of ELOVL7 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of ELOVL7 mRNA18301758|2081375
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ELOVL7 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ELOVL7 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of ELOVL7 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of ELOVL7 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ELOVL7 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ELOVL7 mRNA23806026
D012906SmokeSmoke results in decreased expression of ELOVL7 mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ELOVL7 mRNA26377647|2823826
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of ELOVL7 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ELOVL7 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ELOVL7 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ELOVL7 mRNA20133372
D014212TretinoinTretinoin results in increased expression of ELOVL7 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of ELOVL7 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ELOVL7 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ELOVL7 mRNA"26179874
D014520UrethaneUrethane results in increased expression of ELOVL7 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ELOVL7 mRNA23179753|2915479
D014638VanadatesVanadates results in decreased expression of ELOVL7 mRNA22714537
C029297vinylidene chloridevinylidene chloride results in decreased expression of ELOVL7 mRNA26682919
D015034Zinc OxideZinc Oxide affects the expression of ELOVL7 mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20937905  25416956  
GO:0009922fatty acid elongase activity-EXP19826053  
GO:0009922fatty acid elongase activity-IBA21873635  
GO:0009922fatty acid elongase activity-TAS-  
GO:01023363-oxo-arachidoyl-CoA synthase activity-IEA-  
GO:01023373-oxo-cerotoyl-CoA synthase activity-IEA-  
GO:01023383-oxo-lignoceronyl-CoA synthase activity-IEA-  
GO:0102756very-long-chain 3-ketoacyl-CoA synthase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0019367fatty acid elongation, saturated fatty acid-IBA21873635  
GO:0019367fatty acid elongation, saturated fatty acid-IDA19826053  
GO:0030148sphingolipid biosynthetic process-IBA21873635  
GO:0034625fatty acid elongation, monounsaturated fatty acid-IBA21873635  
GO:0034626fatty acid elongation, polyunsaturated fatty acid-IBA21873635  
GO:0034626fatty acid elongation, polyunsaturated fatty acid-IDA20937905  
GO:0035338long-chain fatty-acyl-CoA biosynthetic process-TAS-  
GO:0042761very long-chain fatty acid biosynthetic process-IBA21873635  
GO:0042761very long-chain fatty acid biosynthetic process-IDA19826053  20937905  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA20937905  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26422515Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease. (2016 Jan)Janse ICInflamm Bowel Dis