Gene: CALD1

800
CDM|H-CAD|HCAD|L-CAD|LCAD|NAG22
caldesmon 1
protein-coding
7q33
Ensembl:ENSG00000122786 MIM:114213 Vega:OTTHUMG00000155407 UniprotKB:Q05682
NG_029186.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.214e-1 (AD)  5.097e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2347896chr7:134780643 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KANK20.873
ITGB10.862
ROCK10.855
EPS80.846
JAG10.833
TLN10.832
TGFB1I10.83
BNIP20.827
FOXC10.825
EPAS10.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.494
HAS1-0.485
DLK2-0.482
SLC7A4-0.48
MARCH4-0.476
KCNB2-0.466
ADRA1D-0.464
PPEF1-0.459
CRH-0.45
LRTM2-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of CALD1 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CALD1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CALD1 mRNA21420995|2669055
D000082AcetaminophenAcetaminophen affects the expression of CALD1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CALD1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CALD1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CALD1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CALD1 mRNA24449571
D001151ArsenicArsenic affects the methylation of CALD1 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of CALD1 mRNA22535156
C015001arsenitearsenite results in decreased methylation of CALD1 promoter23974009
D001374AzacitidineAzacitidine results in increased expression of CALD1 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CALD1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CALD1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CALD1 mRNA"20018196
C044887beta-methylcholinebeta-methylcholine affects the expression of CALD1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CALD1 mRNA25181051
D001761BleomycinBleomycin results in increased expression of CALD1 protein25933445
D002065BuspironeBuspirone results in decreased expression of CALD1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CALD1 protein24419708
D002220CarbamazepineCarbamazepine affects the expression of CALD1 mRNA25979313
D002737ChloropreneChloroprene results in increased expression of CALD1 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of CALD1 mRNA19320972
D003042CocaineCocaine affects the expression of CALD1 mRNA20187946
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CALD1 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CALD1 mRNA15467011
C009160cyclonitecyclonite results in decreased expression of CALD1 mRNA25559034
C515055darinaparsindarinaparsin results in increased expression of CALD1 mRNA22535156
C515055darinaparsinOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CALD1 mRNA]22535156
D003703DemecolcineDemecolcine results in increased expression of CALD1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CALD1 mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of CALD1 protein22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of CALD1 mRNA26924002
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of CALD1 mRNA21852083
C024629dimethyl phthalatedimethyl phthalate results in increased expression of CALD1 mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CALD1 mRNA24690739
D004237DiuronDiuron results in increased expression of CALD1 mRNA21551480
D004317DoxorubicinCALD1 mRNA affects the susceptibility to Doxorubicin16044152
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CALD1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CALD1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CALD1 mRNA23300682
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CALD1 mRNA15576828
C540355fenamidonefenamidone results in increased expression of CALD1 mRNA27029645
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of CALD1 mRNA10854235
D005485FlutamideFlutamide results in decreased expression of CALD1 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of CALD1 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of CALD1 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of CALD1 mRNA26705709
D019833GenisteinGenistein results in increased expression of CALD1 protein22649256
D017313FenretinideFenretinide results in decreased expression of CALD1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of CALD1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CALD1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of CALD1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CALD1 mRNA24796395
D007854LeadLead results in increased expression of CALD1 mRNA19921347
C008261lead acetatelead acetate results in decreased expression of CALD1 mRNA11578147
C029891lead chloridelead chloride results in decreased expression of CALD1 protein24419708
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CALD1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CALD1 mRNA"26251327
D008774MethylphenidateMethylphenidate results in increased expression of CALD1 mRNA22470460
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CALD1 mRNA24810058
C540575MK2i peptide[TGFB1 protein co-treated with MK2i peptide] results in decreased expression of CALD1 protein20864298
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of CALD1 mRNA26924002
C028473N-acetyl-4-benzoquinoneimineCALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CALD1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CALD1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CALD1 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of CALD1 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CALD1 mRNA25729387
D010100OxygenOxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CALD1 mRNA]22535156
D010100OxygenOxygen deficiency results in increased expression of CALD1 mRNA24205000
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CALD1 mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CALD1 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of CALD1 mRNA19270015|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CALD1 mRNA"27188386
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate affects the expression of CALD1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of CALD1 mRNA18445702
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CALD1 protein23718831
D011192Potassium DichromatePotassium Dichromate results in increased expression of CALD1 mRNA11678601
D011192Potassium DichromatePotassium Dichromate results in increased expression of CALD1 mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of CALD1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of CALD1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CALD1 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of CALD1 mRNA19429434
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of CALD1 mRNA21852083
D015474IsotretinoinIsotretinoin results in increased expression of CALD1 mRNA20436886
C010327salinomycinsalinomycin results in decreased expression of CALD1 mRNA19682730
D012643SeleniumSelenium results in decreased expression of CALD1 mRNA19244175
D012715Sesame OilSesame Oil results in decreased expression of CALD1 mRNA29191790
D012834SilverSilver results in increased expression of CALD1 mRNA28959546
D019821SimvastatinSimvastatin results in decreased expression of CALD1 mRNA14630613
D019821SimvastatinSimvastatin results in decreased expression of CALD1 protein14630613
D020123Sirolimus[Sirolimus co-treated with IGF1 protein] results in increased expression of CALD1 protein17908691
D020123Sirolimus[Sirolimus results in increased activity of AKT2 protein] which results in increased expression of CALD1 protein17908691
D020123SirolimusSirolimus results in increased expression of CALD1 protein17908691
D012906SmokeSmoke results in decreased expression of CALD1 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of CALD1 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of CALD1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of CALD1 gene28589171
C017947sodium arsenitesodium arsenite results in increased stability of CALD1 mRNA25493608
D012969Sodium FluorideSodium Fluoride results in decreased expression of CALD1 protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CALD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CALD1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CALD1 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of CALD1 protein20109541
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of CALD1 protein20109541
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CALD1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CALD1 mRNA28111298
D014050TolueneToluene results in increased expression of CALD1 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CALD1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CALD1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of CALD1 mRNA23228038
C012589trichostatin Atrichostatin A results in increased expression of CALD1 mRNA24935251|2670570
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CALD1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CALD1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of CALD1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CALD1 mRNA26272509|2670570
D014640VancomycinVancomycin results in decreased expression of CALD1 mRNA18930951
D014750VincristineVincristine results in increased expression of CALD1 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of CALD1 mRNA19244175
D015032ZincZinc results in increased expression of CALD1 mRNA16870260
C016837zinc chloridezinc chloride results in increased expression of CALD1 mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI21044950  
GO:0005516calmodulin binding-IEA-  
GO:0005523tropomyosin binding-TAS1555769  
GO:0017022myosin binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS16130169  
GO:0005886plasma membrane-IDA-  
GO:0015629actin cytoskeleton-IDA-  
GO:0030016myofibril-IEA-  
GO:0030478actin cap-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal