Gene: PSCA

8000
PRO232
prostate stem cell antigen
protein-coding
8q24.3
Ensembl:ENSG00000167653 MIM:602470 Vega:OTTHUMG00000162077 UniprotKB:O43653
NG_011722.3
PubMed
0   ANCO-SNPs
ND
6   
5.788e-1 (AD)  9.548e-1 (ND)   (Frontal_Cortex)
6.472e-1 (AD)  4.844e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFF20.485
PIF10.448
GKN10.435
TFF10.428
PROM20.427
MUC5AC0.425
CCR100.421
IDUA0.418
PCSK40.414
FTCD0.414

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHAC2-0.229
TRIM61-0.229
FOXD1-0.224
FHL5-0.212
EGFLAM-0.207
FAM124B-0.206
RASSF9-0.204
OR13C9-0.203
TTR-0.203
HIST1H1T-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane results in decreased expression of PSCA mRNA"28591870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PSCA mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of PSCA mRNA"28591870
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]"14761676
D000082AcetaminophenAcetaminophen results in decreased expression of PSCA mRNA29067470
C109238acylineacyline results in decreased expression of PSCA mRNA17510436
C501521Akt-I-1,2 compound"Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]"16949054
D000638AmiodaroneAmiodarone results in decreased expression of PSCA mRNA17991464
D000728AndrogensAndrogens affects the expression of PSCA protein16015594
D047310ApigeninApigenin results in decreased expression of PSCA mRNA18331776
C015001arsenitearsenite results in decreased methylation of PSCA promoter23974009
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PSCA mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PSCA mRNA19619570
D004958EstradiolEstradiol results in decreased expression of PSCA mRNA19619570|2859187
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of PSCA mRNA28591870
C006780bisphenol Abisphenol A results in decreased expression of PSCA mRNA28591870|2871154
C006780bisphenol Abisphenol A results in decreased expression of PSCA mRNA22687993
C492482bisphenol Bbisphenol B results in decreased expression of PSCA mRNA28591870
C000611646bisphenol Fbisphenol F results in decreased expression of PSCA mRNA28591870
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PSCA mRNA14729362|1500399
C043561chrysinchrysin results in decreased expression of PSCA mRNA18331776
C018021cobaltous chloridecobaltous chloride results in decreased expression of PSCA mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of PSCA mRNA20106945
D002945CisplatinCisplatin results in increased expression of PSCA mRNA27392435
D005480FlurbiprofenAKT1 protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]16949054
D005480Flurbiprofen"Akt-I-1,2 compound inhibits the reaction [Flurbiprofen results in increased expression of PSCA protein]"16949054
D005480FlurbiprofenFlurbiprofen results in increased expression of PSCA mRNA16949054
D005480Flurbiprofen[Flurbiprofen results in increased phosphorylation of and results in increased activity of PSCA protein] which results in increased expression of AKT1 protein16949054
D005480FlurbiprofenHRAS protein affects the reaction [Flurbiprofen results in increased expression of PSCA mRNA]16949054
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PSCA mRNA20044591
C006552kaempferolkaempferol results in decreased expression of PSCA mRNA18331776
D047311LuteolinLuteolin results in decreased expression of PSCA mRNA18331776|1939799
C040015myricetinmyricetin results in decreased expression of PSCA mRNA18331776
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PSCA mRNA"25554681
D010126OzoneOzone results in increased expression of PSCA mRNA25658374
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]14761676
C005556propionaldehydepropionaldehyde results in increased expression of PSCA mRNA26079696
D011794QuercetinQuercetin results in decreased expression of PSCA mRNA18331776
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PSCA mRNA25895662
D012906SmokeSmoke results in increased expression of PSCA mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of PSCA mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of PSCA mRNA12727804
C016104sodium bichromatesodium bichromate results in decreased expression of PSCA mRNA22155349
C025463sulindac sulfonesulindac sulfone results in increased expression of PSCA mRNA16949054
D014284Triiodothyronine"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]"14761676
D014284TriiodothyroninePolychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of PSCA mRNA]14761676
D014284TriiodothyronineTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA mRNA]14761676
D014284TriiodothyronineTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA protein]14761676
D014284TriiodothyronineTriiodothyronine results in increased expression of PSCA mRNA14761676
D014284TriiodothyronineTriiodothyronine results in increased expression of PSCA protein14761676
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PSCA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA mRNA]14761676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of PSCA protein]14761676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PSCA mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSCA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PSCA mRNA17035482
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PSCA protein27818348
D014635Valproic AcidValproic Acid results in increased methylation of PSCA gene29154799
D015034Zinc OxideZinc Oxide analog results in increased expression of PSCA mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0033130acetylcholine receptor binding-IDA25680266  
GO ID GO Term Qualifier Evidence PubMed
GO:0070373negative regulation of ERK1 and ERK2 cascade-IDA25680266  
GO:0099601regulation of neurotransmitter receptor activity-IDA25680266  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-IBA21873635  
GO:0031225anchored component of membrane-IBA21873635  
GO:0031225anchored component of membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25374226Genetic variation in PSCA is associated with bladder cancer susceptibility in a Korean population. (2014)Lee JHAsian Pac J Cancer Prev
26586467The prototoxin LYPD6B modulates heteromeric alpha3beta4-containing nicotinic acetylcholine receptors, but not alpha7 homomers. (2016 Mar)Ochoa VFASEB J
20131315Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population. (2010 Nov 1)Lu YInt J Cancer
24155119Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer. (2014 Jan)Wang PGenes Chromosomes Cancer
20153630Common predisposition alleles for moderately common cancers: bladder cancer. (2010 Jun)Kiltie AECurr Opin Genet Dev
25721731Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. (2015 Sep 15)Garcia-Gonzalez MAInt J Cancer