Gene: TRAPPC13

80006
C5orf44
trafficking protein particle complex 13
protein-coding
5q12.3
Ensembl:ENSG00000253251 Vega:OTTHUMG00000163649 UniprotKB:A5PLN9
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.609e-2 (AD)  5.692e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17241135chr5:65653767 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATAD10.962
MTMR60.948
BTF3L40.948
BRWD10.948
SLC25A460.946
OPA10.946
ERLEC10.944
ADSS0.944
UBLCP10.942
PJA20.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.542
OR4F29-0.501
MTRNR2L6-0.44
MTRNR2L10-0.437
CSAG1-0.435
MTRNR2L9-0.429
EVC2-0.388
MTRNR2L8-0.387
FOXJ1-0.377
MTRNR2L2-0.373

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TRAPPC13 mRNA"19114083
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TRAPPC13 mRNA21298039
D001280AtrazineAtrazine results in decreased expression of TRAPPC13 mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of TRAPPC13 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TRAPPC13 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of TRAPPC13 mRNA19549813
C000944dicrotophosdicrotophos results in decreased expression of TRAPPC13 mRNA28302478
D004026DieldrinDieldrin results in increased expression of TRAPPC13 mRNA20438755
D005485FlutamideFlutamide results in increased expression of TRAPPC13 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of TRAPPC13 mRNA20655997
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TRAPPC13 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TRAPPC13 mRNA18951874
C544151jinfukangjinfukang results in decreased expression of TRAPPC13 mRNA27392435
C410337K 7174K 7174 results in increased expression of TRAPPC13 mRNA24086573
D007854LeadLead results in increased expression of TRAPPC13 mRNA19921347
C045463leflunomideleflunomide results in decreased expression of TRAPPC13 mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TRAPPC13 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of TRAPPC13 mRNA24136188
D010269ParaquatParaquat results in increased expression of TRAPPC13 mRNA26824344
D010416PentachlorophenolPentachlorophenol results in increased expression of TRAPPC13 mRNA24642059
D010936Plant ExtractsPlant Extracts results in increased expression of TRAPPC13 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRAPPC13 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of TRAPPC13 mRNA23012394
C017947sodium arsenitesodium arsenite results in decreased expression of TRAPPC13 mRNA22714537
D013849ThimerosalThimerosal results in increased expression of TRAPPC13 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TRAPPC13 mRNA28065790
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRAPPC13 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TRAPPC13 mRNA23034163
C111237vorinostatvorinostat results in increased expression of TRAPPC13 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21453443  29656893  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0045830positive regulation of isotype switching-IDA29656893  
GO:2000042negative regulation of double-strand break repair via homologous recombination-IDA29656893  
GO:2001034positive regulation of double-strand break repair via nonhomologous end joining-IDA29656893  
GO ID GO Term Qualifier Evidence PubMed
GO:0005694chromosome-IDA29656893  
GO:0005829cytosol-TAS-  
GO:0035861site of double-strand break-IDA29656893  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal