Gene: CSRNP3

80034
FAM130A2|PPP1R73|TAIP-2|TAIP2
cysteine and serine rich nuclear protein 3
protein-coding
2q24.3
Ensembl:ENSG00000178662 Vega:OTTHUMG00000132145 UniprotKB:Q8WYN3
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.287e-1 (AD)  8.381e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10211296chr2:165633833 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC2A130.961
FRRS1L0.958
SCN2A0.954
ELOVL40.952
SCAMP10.95
CLVS20.95
GABRA40.948
TRIM230.948
CHL10.947
GLRB0.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.63
RUNX3-0.521
CNN2-0.519
RNF135-0.507
MAGEA12-0.507
FZD10-0.501
SYDE1-0.501
HEY2-0.496
MYL3-0.495
CMTM3-0.492

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CSRNP3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CSRNP3 mRNA29067470
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CSRNP3 mRNA24449571
D004958EstradiolEstradiol results in increased expression of CSRNP3 mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of CSRNP3 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of CSRNP3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CSRNP3 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of CSRNP3 gene28505145
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CSRNP3 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of CSRNP3 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CSRNP3 mRNA21266533
C118739entinostatentinostat results in decreased expression of CSRNP3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CSRNP3 mRNA29097150
C039281furanfuran results in decreased expression of CSRNP3 mRNA26194646
D007854LeadLead affects the expression of CSRNP3 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CSRNP3 mRNA26272509|2800136
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CSRNP3 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CSRNP3 mRNA24810058
D009532NickelNickel results in decreased expression of CSRNP3 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CSRNP3 mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CSRNP3 mRNA26705709
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CSRNP3 mRNA19710929
D012999SomanSoman results in increased expression of CSRNP3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSRNP3 mRNA24058054
C483909torcetrapibtorcetrapib results in increased expression of CSRNP3 mRNA23228038
D014212TretinoinTretinoin results in increased expression of CSRNP3 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CSRNP3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CSRNP3 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of CSRNP3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CSRNP3 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of CSRNP3 gene29154799
C025643vinclozolinvinclozolin affects the expression of CSRNP3 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-ISS17726538  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS17726538  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS17726538  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal