Gene: TRPM3

80036
GON-2|LTRPC3|MLSN2
transient receptor potential cation channel subfamily M member 3
protein-coding
9q21.12-q21.13
Ensembl:ENSG00000083067 MIM:608961 Vega:OTTHUMG00000019997 UniprotKB:Q9HCF6
NG_047197.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.268e-1 (AD)  7.132e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10114679chr9:70609644 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSL60.771
LSAMP0.747
CNTN10.738
KIAA03190.728
GREB10.723
FUT90.722
CADM20.714
ENPP50.709
ASTN10.708
FMN20.701

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.427
TNFAIP8-0.418
BEST3-0.409
SGMS2-0.405
OR4F5-0.404
ELF4-0.401
MSLN-0.398
TNFSF14-0.398
NCF4-0.392
PLEKHA4-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TRPM3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPM3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TRPM3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRPM3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TRPM3 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of TRPM3 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of TRPM3 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRPM3 mRNA27195522
C006780bisphenol Abisphenol A affects the expression of TRPM3 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of TRPM3 mRNA25979313
C029892cupric chloridecupric chloride results in decreased expression of TRPM3 mRNA24650576
D003471CuprizoneCuprizone results in increased expression of TRPM3 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of TRPM3 mRNA22147139
C118739entinostatentinostat results in decreased expression of TRPM3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM3 mRNA"27188386
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of TRPM3 mRNA22563483
D008694MethamphetamineTRPM3 gene SNP affects the susceptibility to Methamphetamine18316681
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TRPM3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TRPM3 mRNA23179753|2718838
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of TRPM3 mRNA22563483
D010269ParaquatParaquat results in increased expression of TRPM3 mRNA22563483
D011374ProgesteroneProgesterone results in decreased expression of TRPM3 mRNA23018184
C005556propionaldehydepropionaldehyde results in decreased expression of TRPM3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of TRPM3 mRNA24780913
C428725pyridabenpyridaben results in increased expression of TRPM3 mRNA22563483
D012524SarinSarin results in increased expression of TRPM3 mRNA19522546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPM3 mRNA21570461
D013849ThimerosalThimerosal results in increased expression of TRPM3 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of TRPM3 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of TRPM3 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of TRPM3 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TRPM3 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of TRPM3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of TRPM3 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRPM3 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRPM3 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TRPM3 mRNA26272509
D015032ZincZinc deficiency results in increased expression of TRPM3 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005227calcium activated cation channel activity-IEA-  
GO:0005261cation channel activity-IDA15824111  
GO:0005262calcium channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-IDA15824111  
GO:0016048detection of temperature stimulus-IEA-  
GO:0050951sensory perception of temperature stimulus-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:0070588calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal