Gene: THOC7

80145
NIF3L1BP1|fSAP24|hTREX30
THO complex 7
protein-coding
3p14.1
Ensembl:ENSG00000163634 MIM:611965 Vega:OTTHUMG00000158767 UniprotKB:Q6I9Y2
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.738e-1 (AD)  5.394e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SUMO10.956
BEX40.95
POLR2K0.949
AP3S10.948
EID10.946
SKP10.946
FKBP30.944
PFDN40.943
TCEAL80.942
VPS290.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.738
OR4F29-0.718
RUNX3-0.297
KCNK5-0.286
MAGEA12-0.286
FOLR3-0.285
ZBTB20-0.283
EVC2-0.28
KCNJ15-0.28
MTRNR2L10-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of THOC7 mRNA"19114083
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of THOC7 mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of THOC7 mRNA21420995
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of THOC7 mRNA21298039
D001280AtrazineAtrazine results in increased expression of THOC7 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of THOC7 mRNA22378314
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA24657404
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of THOC7 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of THOC7 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of THOC7 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of THOC7 mRNA29275510
D019327Copper SulfateCopper Sulfate results in decreased expression of THOC7 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of THOC7 mRNA28628672
D005485FlutamideFlutamide results in increased expression of THOC7 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of THOC7 mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of THOC7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of THOC7 mRNA28628672
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of THOC7 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of THOC7 mRNA26011545
C025256nonylphenolnonylphenol results in increased expression of THOC7 mRNA22982499
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of THOC7 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of THOC7 mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in increased expression of THOC7 mRNA23608068
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of THOC7 mRNA25729387
D014520UrethaneUrethane results in decreased expression of THOC7 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions affects the methylation of THOC7 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of THOC7 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0005515protein binding-IPI12951069  19059247  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-IBA21873635  
GO:0006406mRNA export from nucleus-IDA17190602  
GO:0006406mRNA export from nucleus-TAS-  
GO:0008380RNA splicing-IEA-  
GO:0031124mRNA 3'-end processing-TAS-  
GO:0046784viral mRNA export from host cell nucleus-IDA18974867  
GO ID GO Term Qualifier Evidence PubMed
GO:0000346transcription export complex-IDA15833825  15998806  
GO:0000347THO complex-IDA15998806  
GO:0000445THO complex part of transcription export complex-IBA21873635  
GO:0000445THO complex part of transcription export complex-IDA15998806  
GO:0000781chromosome, telomeric region-IBA21873635  
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIDA24270157  
GO:0005634nucleus-IDA12951069  19059247  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA12951069  
GO:0005829cytosol-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28416970DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. (2017)Sundar IKClin Epigenetics