Gene: UXS1

80146
SDR6E1|UGD
UDP-glucuronate decarboxylase 1
protein-coding
2q12.2
Ensembl:ENSG00000115652 MIM:609749 Vega:OTTHUMG00000153150 UniprotKB:Q8NBZ7
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.315e-1 (AD)  3.777e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10206195chr2:106097582 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07992484chr2:106724161UXS17.400e-15Smoking27651444
cg00295485chr2:106755721UXS13.400e-14Smoking27651444
cg05138138chr2:106764528UXS11.300e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUL10.938
GOT20.931
ABCF20.928
PGK10.928
CCNDBP10.928
UBP10.927
ATP1A10.926
CHMP70.925
CLTC0.925
DDX240.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.609
OR4F29-0.574
MTRNR2L6-0.395
MTRNR2L10-0.393
ASB4-0.385
MTRNR2L9-0.379
MBNL3-0.359
MYL3-0.353
PARD3B-0.34
KLF17-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UXS1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of UXS1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UXS1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UXS1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UXS1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UXS1 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of UXS1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of UXS1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of UXS1 mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UXS1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of UXS1 mRNA22378314
D001663BilirubinBilirubin results in decreased expression of UXS1 mRNA20196124
C006780bisphenol Abisphenol A affects the expression of UXS1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of UXS1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of UXS1 mRNA25181051
D003042CocaineCocaine affects the expression of UXS1 mRNA20187946
D009243NAD[thymidine 5'-diphosphate co-treated with NAD] binds to UXS1 protein25526675
D009243NAD[Uridine Diphosphate Galactose co-treated with NAD] binds to UXS1 protein25526675
D009243NAD[Uridine Diphosphate Glucose co-treated with NAD] binds to UXS1 protein25526675
D009243NAD[Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein25526675
D016572CyclosporineCyclosporine results in decreased expression of UXS1 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of UXS1 mRNA21266533
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of UXS1 mRNA"22485181
D018120FinasterideFinasteride results in increased expression of UXS1 mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of UXS1 mRNA18035473
D005485FlutamideFlutamide results in increased expression of UXS1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of UXS1 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of UXS1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UXS1 mRNA25613284
C410337K 7174K 7174 results in increased expression of UXS1 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of UXS1 mRNA20542052
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UXS1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UXS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UXS1 mRNA"25554681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UXS1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of UXS1 mRNA23892564
C006253pirinixic acidpirinixic acid results in increased expression of UXS1 mRNA17426115
D059808PolyphenolsPolyphenols results in decreased expression of UXS1 mRNA16293270
D012715Sesame OilSesame Oil results in decreased expression of UXS1 mRNA29191790
C017947sodium arsenitesodium arsenite results in decreased expression of UXS1 mRNA20371982
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of UXS1 mRNA25260812
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UXS1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UXS1 mRNA25613284
C027923thymidine 5'-diphosphate[thymidine 5'-diphosphate co-treated with NAD] binds to UXS1 protein25526675
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of UXS1 mRNA28065790
D014531Uridine Diphosphate Galactose[Uridine Diphosphate Galactose co-treated with NAD] binds to UXS1 protein25526675
D014532Uridine Diphosphate Glucose[Uridine Diphosphate Glucose co-treated with NAD] binds to UXS1 protein25526675
D014535Uridine Diphosphate Glucuronic Acid[Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein25526675
D014635Valproic AcidValproic Acid affects the expression of UXS1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UXS1 mRNA23179753|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of UXS1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of UXS1 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042803protein homodimerization activity-IDA23656592  
GO:0048040UDP-glucuronate decarboxylase activity-IBA21873635  
GO:0048040UDP-glucuronate decarboxylase activity-IDA23072385  23656592  
GO:0070403NAD+ binding-IBA21873635  
GO:0070403NAD+ binding-IDA23072385  
GO ID GO Term Qualifier Evidence PubMed
GO:0033320UDP-D-xylose biosynthetic process-IEA-  
GO:0051262protein tetramerization-IDA23656592  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00500Starch and sucrose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal