Gene: CTC1

80169
AAF-132|AAF132|C17orf68|CRMCC|tmp494178
CST telomere replication complex component 1
protein-coding
17p13.1
Ensembl:ENSG00000178971 MIM:613129 Vega:OTTHUMG00000178443 UniprotKB:Q2NKJ3
NG_032148.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.938e-1 (AD)  7.422e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPH10.926
MAP3K120.924
SUGP20.923
ZMYM30.918
ADCY60.909
HERC20.907
HERC10.907
GGA30.907
EP4000.906
GBF10.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.472
OR4F29-0.438
LRAT-0.372
COPZ2-0.371
HEY2-0.362
ZNF114-0.352
IL20RA-0.351
RAB13-0.345
NXT2-0.338
ROM1-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTC1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CTC1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CTC1 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of CTC1 mRNA19774075
D001151ArsenicArsenic affects the methylation of CTC1 gene25304211
D001280AtrazineAtrazine results in decreased expression of CTC1 mRNA27655631
C006780bisphenol Abisphenol A results in increased expression of CTC1 mRNA25181051
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTC1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CTC1 mRNA26272509
D016572CyclosporineCyclosporine results in increased expression of CTC1 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of CTC1 promoter27989131
C000944dicrotophosdicrotophos results in increased expression of CTC1 mRNA28302478
D005557FormaldehydeCTC1 gene affects the susceptibility to Formaldehyde27008852
D005557FormaldehydeFormaldehyde results in decreased expression of CTC1 mRNA23649840
C544151jinfukangjinfukang results in increased expression of CTC1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CTC1 mRNA24796395
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CTC1 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CTC1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CTC1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CTC1 mRNA"25620056
C006253pirinixic acidpirinixic acid results in increased expression of CTC1 mRNA23811191
D011794QuercetinQuercetin results in increased expression of CTC1 mRNA21632981
D018038Sodium SeleniteSodium Selenite results in decreased expression of CTC1 mRNA18175754
C025643vinclozolinvinclozolin results in decreased expression of CTC1 mRNA23555832
D014750VincristineVincristine results in decreased expression of CTC1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-ISS-  
GO:0005515protein binding-IPI19854130  22763445  25416956  
GO:0042162telomeric DNA binding-IBA21873635  
GO:0042162telomeric DNA binding-IDA19854130  
GO:0098505G-rich strand telomeric DNA binding-IDA22763445  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP19854131  
GO:0006974cellular response to DNA damage stimulus-IEA-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-IEA-  
GO:0010833telomere maintenance via telomere lengthening-IBA21873635  
GO:0010833telomere maintenance via telomere lengthening-IEA-  
GO:0016233telomere capping-TAS22763445  
GO:0032211negative regulation of telomere maintenance via telomerase-IDA22763445  
GO:0035264multicellular organism growth-IEA-  
GO:0045740positive regulation of DNA replication-IBA21873635  
GO:0045740positive regulation of DNA replication-ISS-  
GO:0048146positive regulation of fibroblast proliferation-IEA-  
GO:0048536spleen development-IEA-  
GO:0048538thymus development-IEA-  
GO:0048539bone marrow development-IEA-  
GO:0071425hematopoietic stem cell proliferation-IEA-  
GO:0090399replicative senescence-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-IDA19854130  
GO:0005634nucleus-IDA19854130  
GO:0005634nucleus-ISS-  
GO:1990879CST complex-IBA21873635  
GO:1990879CST complex-IDA19854130  22763445  
GO:1990879CST complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301779Dyskeratosis Congenita (1993)Savage SA-