Gene: BRD3

8019
ORFX|RING3L
bromodomain containing 3
protein-coding
9q34.2
Ensembl:ENSG00000169925 MIM:601541 Vega:OTTHUMG00000021004 UniprotKB:Q15059
NC_000009.12
PubMed
0   ANCO-SNPs
CD|ND
2   
5.290e-1 (AD)  1.934e-1 (ND)   (Frontal_Cortex)
8.102e-1 (AD)  1.432e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO18A0.872
DCAF70.861
MPDZ0.858
GIGYF20.853
ZC3H130.84
EIF3A0.838
SPTBN10.836
RAB5B0.834
BPTF0.829
USP340.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.557
OR4F5-0.519
PRRX2-0.257
MUC12-0.254
PDZK1IP1-0.245
OR4F16-0.242
GRHL2-0.237
C17orf112-0.237
OR7A17-0.223
KRTAP4-3-0.22

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BRD3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BRD3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BRD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BRD3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BRD3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BRD3 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BRD3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BRD3 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of BRD3 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BRD3 mRNA20498004
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BRD3 mRNA"20018196
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BRD3 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of BRD3 mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of BRD3 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of BRD3 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD3 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of BRD3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of BRD3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of BRD3 mRNA25562108
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of BRD3 protein23811945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BRD3 mRNA28628672
C000944dicrotophosdicrotophos results in increased expression of BRD3 mRNA28302478
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRD3 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of BRD3 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD3 gene20938992
C039281furanfuran results in increased methylation of BRD3 gene22079235
D005897GlafenineGlafenine results in decreased expression of BRD3 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BRD3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BRD3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in decreased expression of BRD3 mRNA25989842
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in increased expression of BRD3 mRNA25989842
C561695(+)-JQ1 compound(+)-JQ1 compound binds to BRD3 protein20871596
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD3 protein binds to BCL2L1 promoter]24759320
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD3 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD3 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD3 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD3 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD3 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD3 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF protein]"23420887
D008627Mercuric ChlorideMercuric Chloride affects the expression of BRD3 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BRD3 gene20938992
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of BRD3 mRNA22401849
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of BRD3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BRD3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BRD3 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of BRD3 mRNA24136188
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD3 mRNA"12756304
C000605331OTX015OTX015 results in decreased expression of BRD3 mRNA27388964
D010100OxygenOxygen deficiency results in increased expression of BRD327292261
C016030pantogabpantogab results in decreased expression of BRD3 mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BRD3 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BRD3 mRNA18804290
D010634PhenobarbitalPhenobarbital affects the expression of BRD3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BRD3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of BRD3 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of BRD3 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of BRD3 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of BRD3 mRNA21278054
C017947sodium arsenitesodium arsenite affects the expression of BRD3 mRNA29319823
D012999SomanSoman results in decreased expression of BRD3 mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of BRD3 mRNA"26680231
C061133tamibarotenetamibarotene affects the expression of BRD3 mRNA15498508
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRD3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BRD3 mRNA21215274
D014212TretinoinTretinoin results in decreased expression of BRD3 mRNA15498508
C057693troglitazonetroglitazone results in decreased expression of BRD3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of BRD3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BRD3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of BRD3 gene29154799
C025643vinclozolinvinclozolin affects the expression of BRD3 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA18406326  
GO:0005515protein binding-IPI20195357  
GO:0070577lysine-acetylated histone binding-IDA22464331  27105114  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA18406326  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26001144Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. (2015 Jun)Sholl LMJ Thorac Oncol
26558777Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. (2015 Nov 11)Sartor GCJ Neurosci