Gene: FUZ

80199
CPLANE3|FY|NTD
fuzzy planar cell polarity protein
protein-coding
19q13.33
Ensembl:ENSG00000010361 MIM:610622 Vega:OTTHUMG00000167281 UniprotKB:Q9BT04
NG_032843.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.621e-1 (AD)  1.548e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2286948chr19:49813497 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFYVE190.889
TBC1D170.887
FAM3A0.885
KEAP10.885
NDUFS70.874
CYHR10.869
BOLA10.869
ILVBL0.864
GRHPR0.862
NUDT16L10.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.67
OR4F29-0.623
GSDMA-0.422
FER1L6-0.413
SIX1-0.409
FCER2-0.404
IL18RAP-0.389
CEACAM3-0.387
TBX21-0.385
SUCNR1-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000638AmiodaroneAmiodarone results in increased expression of FUZ mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FUZ mRNA20127859
C044887beta-methylcholinebeta-methylcholine affects the expression of FUZ mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUZ mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of FUZ mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUZ mRNA28628672
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUZ gene20938992
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUZ mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUZ mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FUZ mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of FUZ mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUZ gene20938992
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUZ mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUZ mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FUZ mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FUZ mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FUZ mRNA27392435
C544151jinfukangjinfukang results in increased expression of FUZ mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of FUZ mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FUZ gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FUZ mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FUZ mRNA"25554681
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FUZ mRNA19710929
D011441PropylthiouracilPropylthiouracil results in increased expression of FUZ mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of FUZ mRNA21427059
C017947sodium arsenitesodium arsenite results in increased expression of FUZ mRNA25879800
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of FUZ mRNA28973375
D014212TretinoinTretinoin results in decreased expression of FUZ mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of FUZ mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FUZ mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  
GO ID GO Term Qualifier Evidence PubMed
GO:0001736establishment of planar polarity-ISS-  
GO:0001843neural tube closure-IMP21840926  
GO:0001843neural tube closure-ISS-  
GO:0001942hair follicle development-ISS-  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0008589regulation of smoothened signaling pathway-ISS-  
GO:0010172embryonic body morphogenesis-ISS-  
GO:0015031protein transport-IEA-  
GO:0030336negative regulation of cell migration-IMP21840926  
GO:0045724positive regulation of cilium assembly-IMP21840926  
GO:0048704embryonic skeletal system morphogenesis-ISS-  
GO:0060271cilium assembly-ISS-  
GO:0090090negative regulation of canonical Wnt signaling pathway-ISS-  
GO:0090301negative regulation of neural crest formation-ISS-  
GO:1905515non-motile cilium assembly-IMP21840926  
GO:2000314negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0042995cell projection-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal