Gene info: ID 80204

Gene: FBXO11

GENE ID: 80204

Synonyms: FBX11|PRMT9|UBR6|UG063H01|VIT1

Description: F-box protein 11

Gene type: protein-coding

Location: 2p16.3

dbXrefs: Ensembl:ENSG00000138081 MIM:607871 Vega:OTTHUMG00000129130 UniprotKB:Q86XK2

RefSeq: NG_008397.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.640e-1 (AD) 5.828e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MTPN	0.949
SMAP1	0.947
TUBGCP4	0.943
FTO	0.942
ARFGEF1	0.941
ASH1L	0.941
RNF111	0.938
PHF20	0.937
AKT3	0.936
MEF2A	0.933

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.449
OR4F29	-0.418
HEY2	-0.402
COPZ2	-0.4
S100A1	-0.398
BCL7C	-0.393
MYL3	-0.386
ROM1	-0.385
CSAG1	-0.381
RAB13	-0.372

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of FBXO11 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXO11 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXO11 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FBXO11 gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of FBXO11 mRNA	24449571
D001104	Arbutin	Arbutin results in increased expression of FBXO11 mRNA	17103032
D001241	Aspirin	Aspirin results in increased expression of FBXO11 mRNA	15928584
D001280	Atrazine	Atrazine results in increased expression of FBXO11 mRNA	22378314
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXO11 mRNA"	19150397\|2001819
D004958	Estradiol	Estradiol affects the expression of FBXO11 mRNA	22574217
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FBXO11 mRNA	20823114
C006780	bisphenol A	bisphenol A results in increased expression of FBXO11 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of FBXO11 promoter	22457795
C054133	casticin	casticin results in decreased expression of FBXO11 mRNA	28444820
D019327	Copper Sulfate	Copper Sulfate results in increased expression of FBXO11 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of FBXO11 mRNA	20106945
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FBXO11 mRNA	20823114
D002945	Cisplatin	Cisplatin results in decreased expression of FBXO11 mRNA	27392435
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FBXO11 mRNA"	22485181
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of FBXO11 mRNA	17555576
D005557	Formaldehyde	Formaldehyde results in decreased expression of FBXO11 mRNA	20655997\|2364984
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FBXO11 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of FBXO11 mRNA	27392435
C410337	K 7174	K 7174 results in increased expression of FBXO11 mRNA	24086573
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of FBXO11 mRNA	20823114
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of FBXO11 mRNA	23649840
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of FBXO11 mRNA	17616710
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of FBXO11 mRNA	25729387
D010936	Plant Extracts	Plant Extracts results in increased expression of FBXO11 mRNA	23557933
D011374	Progesterone	Progesterone results in increased expression of FBXO11 mRNA	18037150
C059514	resveratrol	resveratrol results in decreased expression of FBXO11 mRNA	25905778
D012643	Selenium	Selenium results in decreased expression of FBXO11 mRNA	19244175
D012834	Silver	Silver results in increased expression of FBXO11 mRNA	26014281
D013629	Tamoxifen	Tamoxifen affects the expression of FBXO11 mRNA	17555576
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FBXO11 mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of FBXO11 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of FBXO11 mRNA	25729387
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of FBXO11 gene	27618143
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of FBXO11 mRNA	28666766
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXO11 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of FBXO11 mRNA	23179753\|2493525
D024483	Vitamin K 3	Vitamin K 3 affects the expression of FBXO11 mRNA	20044591
D015032	Zinc	Zinc deficiency results in increased expression of FBXO11 mRNA	22171008

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004842	ubiquitin-protein transferase activity	-	EXP	19028597
GO:0004842	ubiquitin-protein transferase activity	-	NAS	10531035
GO:0004842	ubiquitin-protein transferase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	17098746 20596027 22113614 22632967 25203322 25416956 27705803
GO:0008270	zinc ion binding	-	IEA	-
GO:0016274	protein-arginine N-methyltransferase activity	-	IDA	16487488

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000209	protein polyubiquitination	-	TAS	-
GO:0006464	cellular protein modification process	-	IDA	16487488
GO:0006511	ubiquitin-dependent protein catabolic process	-	NAS	10531037
GO:0007605	sensory perception of sound	-	IEA	-
GO:0016567	protein ubiquitination	-	NAS	10531035
GO:0035246	peptidyl-arginine N-methylation	-	IEA	-
GO:0043687	post-translational protein modification	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000151	ubiquitin ligase complex	-	NAS	10531035 10531037
GO:0005634	nucleus	-	IDA	16487488
GO:0005694	chromosome	-	IEA	-
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IDA	16487488
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8951664	Neddylation	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26116372	MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)	Melnik BC	J Transl Med
16847180	Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. (2006 Jul)	Segade F	Arch Otolaryngol Head Neck Surg