Gene: OPA3

80207
MGA3
OPA3, outer mitochondrial membrane lipid metabolism regulator
protein-coding
19q13.32
Ensembl:ENSG00000125741 MIM:606580 Vega:OTTHUMG00000182125 UniprotKB:Q9H6K4
NG_013332.1
PubMed|SNP Mapped
3   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.563e-1 (AD)  4.185e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16979890chr19:45563060 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1264226chr19:45559909 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs8111589chr19:45531300 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TANGO20.923
RNF1230.918
KIAA01000.916
SLC35E10.914
NICN10.914
EXTL30.913
PEX260.912
LARP10.912
USP220.911
PI4KA0.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.503
MYL3-0.47
OR4F29-0.455
CSAG1-0.443
SNHG18-0.44
HEY2-0.436
YES1-0.435
RAI14-0.431
CLEC2B-0.423
RAB13-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of OPA3 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of OPA3 mRNA24449571
D004958EstradiolEstradiol affects the expression of OPA3 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of OPA3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of OPA3 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of OPA3 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of OPA3 mRNA26191083
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of OPA3 mRNA]27941970
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of OPA3 mRNA23649840
D048628KetolidesKetolides analog affects the expression of OPA3 mRNA24967691
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of OPA3 mRNA23649840
C009277sodium arsenatesodium arsenate results in decreased expression of OPA3 mRNA23922661
D018038Sodium SeleniteSodium Selenite results in increased expression of OPA3 mRNA18175754
D014520UrethaneUrethane results in decreased expression of OPA3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of OPA3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of OPA3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of OPA3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of OPA3 gene25560391
C025643vinclozolinvinclozolin results in increased expression of OPA3 mRNA20566332
D015032ZincZinc results in decreased expression of OPA3 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-IMP15342707  
GO:0019216regulation of lipid metabolic process-IBA21873635  
GO:0050896response to stimulus-IEA-  
GO:0050905neuromuscular process-IEA-  
GO:0070584mitochondrion morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-NAS11668429  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict