Gene: ALPK1

80216
8430410J10Rik|LAK
alpha kinase 1
protein-coding
4q25
Ensembl:ENSG00000073331 MIM:607347 Vega:OTTHUMG00000132911 UniprotKB:Q96QP1
NC_000004.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.309e-1 (AD)  2.703e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAPP10.896
CSF2RB0.89
TLR10.885
PTPRC0.885
RASGRP40.884
PSTPIP20.875
TLR20.873
GAB30.871
MAP3K80.87
HLA-DOA0.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.541
WNT7A-0.536
KCNIP3-0.535
RTN4R-0.492
CPLX3-0.486
EXTL1-0.48
PARD6A-0.479
NEUROD6-0.478
KCNK4-0.476
C15orf59-0.473

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ALPK1 mRNA"28903501
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ALPK1 mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of ALPK1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALPK1 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ALPK1 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ALPK1 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ALPK1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALPK1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ALPK1 gene25435355
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ALPK1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ALPK1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALPK1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ALPK1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ALPK1 mRNA28628672
D001786Blood GlucoseALPK1 protein promotes the reaction [Streptozocin results in increased abundance of Blood Glucose]27542954
C018475butyraldehydebutyraldehyde results in decreased expression of ALPK1 mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ALPK1 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of ALPK1 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ALPK1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALPK1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ALPK1 mRNA28628672
D019422Dietary SucroseDietary Sucrose results in increased expression of ALPK1 mRNA26033743
C118739entinostatentinostat results in increased expression of ALPK1 mRNA26272509
D005557FormaldehydeFormaldehyde results in increased expression of ALPK1 mRNA27664576
C016517indole-3-carbinolindole-3-carbinol affects the expression of ALPK1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ALPK1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALPK1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ALPK1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ALPK1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALPK1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ALPK1 mRNA28628672
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ALPK1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALPK1 mRNA"25620056
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ALPK1 mRNA20971185
D010936Plant ExtractsPlant Extracts results in increased expression of ALPK1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of ALPK1 mRNA23608068
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ALPK1 mRNA23806026|2589566
D013311StreptozocinALPK1 protein promotes the reaction [Streptozocin results in decreased secretion of INS1 protein]27542954
D013311StreptozocinALPK1 protein promotes the reaction [Streptozocin results in increased abundance of Blood Glucose]27542954
D013311StreptozocinALPK1 protein results in increased susceptibility to Streptozocin27542954
D013311Streptozocin[ALPK1 protein results in increased susceptibility to Streptozocin] which results in decreased expression of PRKG2 mRNA27542954
D013311Streptozocin[ALPK1 protein results in increased susceptibility to Streptozocin] which results in increased expression of TGFB1 mRNA27542954
D013311Streptozocin[ALPK1 protein results in increased susceptibility to Streptozocin] which results in increased expression of TGFB1 protein27542954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALPK1 mRNA21889950
D013853ThioacetamideThioacetamide results in increased expression of ALPK1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ALPK1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ALPK1 mRNA"26179874
D014527Uric AcidALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]27542954
D014527Uric AcidALPK1 protein results in increased susceptibility to Uric Acid27542954
D014527Uric AcidUric Acid results in increased expression of ALPK1 mRNA27542954
D014527Uric AcidUric Acid results in increased expression of ALPK1 mRNA27542954
D014635Valproic AcidValproic Acid results in decreased expression of ALPK1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of ALPK1 mRNA28001369|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26137247Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study. (2015 May)Yamada YBiomed Rep
24649057Association between polymorphisms of the alpha-kinase 1 gene and type 2 diabetes mellitus in community-dwelling individuals. (2013 Nov)Shimokata SBiomed Rep