Gene: CDK5RAP3

80279
C53|HSF-27|IC53|LZAP|MST016|OK/SW-cl.114|PP1553
CDK5 regulatory subunit associated protein 3
protein-coding
17q21.32
Ensembl:ENSG00000108465 MIM:608202 Vega:OTTHUMG00000178682 UniprotKB:Q96JB5
NC_000017.11
SNP Mapped
1   ANCO-SNPs
ND
0   
5.558e-2 (AD)  4.315e-2 (ND)   (Frontal_Cortex)
1.994e-1 (AD)  2.432e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4794333chr17:47968129 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QTRT10.925
WDR590.923
SNRNP700.919
TAZ0.916
ANKZF10.916
HDAC60.91
CCNL20.904
UCKL10.903
LUC7L0.902
DPH70.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.652
OR4F29-0.635
MTRNR2L9-0.245
MTRNR2L6-0.23
FER1L6-0.218
IBSP-0.212
KLRB1-0.21
TTLL10-AS1-0.206
C8orf74-0.204
UNC45B-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDK5RAP3 mRNA"19114083
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CDK5RAP3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CDK5RAP3 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of CDK5RAP3 mRNA28959563
D000393Air PollutantsAir Pollutants analog results in decreased expression of CDK5RAP3 mRNA21757418
D019386AlendronateAlendronate affects the expression of CDK5RAP3 mRNA16079270
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK5RAP3 mRNA20504355
C006780bisphenol Abisphenol A affects the expression of CDK5RAP3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CDK5RAP3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK5RAP3 mRNA28628672
C584509C646 compoundC646 compound results in increased expression of CDK5RAP3 mRNA26191083
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CDK5RAP3 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of CDK5RAP3 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CDK5RAP3 mRNA]17585979
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CDK5RAP3 mRNA24690739
D016572CyclosporineCyclosporine results in increased expression of CDK5RAP3 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK5RAP3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDK5RAP3 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CDK5RAP3 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CDK5RAP3 mRNA28302478
D004026DieldrinDieldrin results in increased expression of CDK5RAP3 mRNA23041725
D004147DioxinsDioxins affects the expression of CDK5RAP3 mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CDK5RAP3 mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDK5RAP3 mRNA16079270
D005485FlutamideFlutamide results in decreased expression of CDK5RAP3 mRNA21126777
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CDK5RAP3 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDK5RAP3 mRNA20044591
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CDK5RAP3 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK5RAP3 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of CDK5RAP3 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK5RAP3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CDK5RAP3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of CDK5RAP3 mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CDK5RAP3 mRNA"26251327
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of CDK5RAP3 mRNA24128854
D010416PentachlorophenolPentachlorophenol results in increased expression of CDK5RAP3 mRNA24642059
C006253pirinixic acidpirinixic acid results in decreased expression of CDK5RAP3 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of CDK5RAP3 mRNA23557933
C010313pseudocumenepseudocumene results in decreased expression of CDK5RAP3 protein17337753
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CDK5RAP3 mRNA16079270
C059514resveratrolresveratrol results in increased expression of CDK5RAP3 protein25505154
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CDK5RAP3 mRNA25351596
D012969Sodium FluorideSodium Fluoride results in increased expression of CDK5RAP3 protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDK5RAP3 mRNA26290441
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CDK5RAP3 mRNA28973375
C057693troglitazonetroglitazone results in decreased expression of CDK5RAP3 mRNA19140230
C025643vinclozolinvinclozolin results in decreased expression of CDK5RAP3 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16173922  17353931  17785205  20164180  20228063  25416956  
25910212  
GO:0019901protein kinase binding-IPI19223857  
GO:0019901protein kinase binding-NAS10721722  
GO:0030332cyclin binding-IPI15790566  
GO:0044389ubiquitin-like protein ligase binding-IDA20531390  
GO:0051019mitogen-activated protein kinase binding-IPI21283629  
GO:0051059NF-kappaB binding-IPI17785205  
GO:0097371MDM2/MDM4 family protein binding-IPI16173922  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-ISS-  
GO:0001933negative regulation of protein phosphorylation-IMP17785205  
GO:0007095mitotic G2 DNA damage checkpoint-IMP15790566  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0007420brain development-NAS10915792  
GO:0008283cell proliferation-IDA12054757  
GO:0010921regulation of phosphatase activity-IMP21283629  
GO:0030262apoptotic nuclear changes-IMP23478299  
GO:0030968endoplasmic reticulum unfolded protein response-IMP23152784  
GO:0031398positive regulation of protein ubiquitination-IDA16173922  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IMP17785205  20228063  
GO:0043407negative regulation of MAP kinase activity-IMP21283629  
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation-IMP21283629  
GO:0044818mitotic G2/M transition checkpoint-IMP19223857  
GO:0045664regulation of neuron differentiation-NAS10721722  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0071569protein ufmylation-IDA23152784  
GO:0071901negative regulation of protein serine/threonine kinase activity-IMP19223857  
GO:1900182positive regulation of protein localization to nucleus-IDA16173922  
GO:1901798positive regulation of signal transduction by p53 class mediator-IDA16173922  
GO:1903363negative regulation of cellular protein catabolic process-IDA16173922  
GO:2000060positive regulation of ubiquitin-dependent protein catabolic processNOTIDA16173922  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16173922  
GO:0005730nucleolus-IDA-  
GO:0005730nucleolusNOTIDA16173922  
GO:0005737cytoplasm-IDA15790566  16173922  19223857  20531390  
GO:0005813centrosome-IDA19223857  
GO:0005829cytosol-IDA-  
GO:0005874microtubulecolocalizes_withIDA23478299  
GO:0016020membrane-HDA19946888  
GO:0032991protein-containing complex-IDA20531390  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal