Gene: CUBN

8029
IFCR|MGA1|gp280
cubilin
protein-coding
10p13
Ensembl:ENSG00000107611 MIM:602997 Vega:OTTHUMG00000017741 UniprotKB:O60494
NG_008967.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.654e-1 (AD)  5.445e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12249562chr10:16973406 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3740169chr10:16831548 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DENND4C0.693
SCN11A0.689
AHNAK0.683
PCDHGA30.68
OPHN10.677
RYR30.677
CAPN20.673
DOCK70.67
PIK3C2A0.668
AGBL20.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.306
SST-0.302
GSG1-0.279
SULT2B1-0.277
VGF-0.269
NANOS3-0.258
LCN1-0.256
PNOC-0.251
KRTAP1-1-0.246
SPATA2L-0.244

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTransporter
DB00200HydroxocobalaminSmall Molecule13422-51-0ApprovedTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of CUBN mRNA25064622
D000638AmiodaroneAmiodarone affects the expression of CUBN mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CUBN mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CUBN mRNA22300585
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CUBN mRNA21839799
C006780bisphenol Abisphenol A affects the methylation of CUBN promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of CUBN mRNA25181051
D002104CadmiumCadmium results in decreased expression of CUBN protein24093454
D002104CadmiumLosartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein]24093454
D002746ChlorpromazineChlorpromazine affects the expression of CUBN mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of CUBN mRNA22300585
D019327Copper SulfateCopper Sulfate results in decreased expression of CUBN mRNA17328222
D003471CuprizoneCuprizone results in increased expression of CUBN mRNA26577399
D016572CyclosporineCyclosporine affects the expression of CUBN mRNA25064622
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CUBN mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of CUBN mRNA26033743
C118739entinostatentinostat results in increased expression of CUBN mRNA27188386
D000431EthanolEthanol results in decreased expression of CUBN protein26185205
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CUBN mRNA25064622
C412815GW 4064GW 4064 results in increased expression of CUBN mRNA26655953
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CUBN mRNA24796395
D019808LosartanLosartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein]24093454
D015122MercaptopurineMercaptopurine results in decreased expression of CUBN mRNA23358152
D008694MethamphetamineCUBN gene SNP affects the susceptibility to Methamphetamine18316681
D008713MethimazoleMethimazole results in increased expression of CUBN mRNA22504374
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of CUBN mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CUBN mRNA26924002
C025589ochratoxin Aochratoxin A results in decreased acetylation of CUBN promoter29098329
D010269ParaquatParaquat affects the expression of CUBN mRNA25064622
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CUBN mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CUBN mRNA17426115
D011441PropylthiouracilPropylthiouracil results in increased expression of CUBN mRNA22504374
C016104sodium bichromatesodium bichromate results in decreased expression of CUBN mRNA22155349
C016104sodium bichromatesodium bichromate results in decreased expression of CUBN mRNA22561333
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUBN mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CUBN mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CUBN mRNA27913140
D013752TetracyclineTetracycline affects the expression of CUBN mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of CUBN mRNA25064622
D014212TretinoinTretinoin results in increased expression of CUBN mRNA16236135
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CUBN gene27618143
D014635Valproic AcidValproic Acid affects the expression of CUBN mRNA25064622
D014635Valproic AcidValproic Acid results in increased methylation of CUBN gene29154799
D014640VancomycinVancomycin results in increased expression of CUBN mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of CUBN mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of CUBN mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS9478979  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI14576052  
GO:0008144drug binding-ISS-  
GO:0031419cobalamin binding-IEA-  
GO:0038023signaling receptor activity-TAS10080186  
GO:0042803protein homodimerization activity-IDA10552972  
GO ID GO Term Qualifier Evidence PubMed
GO:0001894tissue homeostasis-NAS11994745  
GO:0006898receptor-mediated endocytosis-NAS11994745  
GO:0007165signal transduction-IEA-  
GO:0008203cholesterol metabolic process-IEA-  
GO:0009235cobalamin metabolic process-TAS-  
GO:0015889cobalamin transport-TAS10080186  
GO:0034384high-density lipoprotein particle clearance-TAS-  
GO:0042359vitamin D metabolic process-TAS-  
GO:0042953lipoprotein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005905clathrin-coated pit-IEA-  
GO:0010008endosome membrane-TAS-  
GO:0016020membrane-TAS9478979  
GO:0016324apical plasma membrane-IDA14576052  
GO:0016324apical plasma membrane-ISS-  
GO:0030139endocytic vesicle-IDA14576052  
GO:0031232extrinsic component of external side of plasma membrane-NAS11994745  
GO:0031526brush border membrane-ISS-  
GO:0031526brush border membrane-NAS11994745  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070062extracellular exosome-IDA21082674  
KEGG ID KEGG Term
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196791Vitamin D (calciferol) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-3296469Defects in cobalamin (B12) metabolismTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3359462Defective AMN causes hereditary megaloblastic anemia 1TAS
R-HSA-3359463Defective CUBN causes hereditary megaloblastic anemia 1TAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8964011HDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal