Gene: CCDC6

8030
D10S170|H4|PTC|TPC|TST1
coiled-coil domain containing 6
protein-coding
10q21.2
Ensembl:ENSG00000108091 MIM:601985 Vega:OTTHUMG00000018284 UniprotKB:Q16204
NG_027819.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.902e-1 (AD)  4.979e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPK10.931
UBQLN20.925
YTHDF20.924
ATP6V1H0.924
MAP2K10.923
FOXJ30.922
CCT80.922
OCRL0.921
CSRNP20.921
DCAF100.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.594
OR4F29-0.541
KLRB1-0.395
CSAG1-0.369
FZD10-0.367
KLRF1-0.342
TFPI2-0.337
MYL3-0.328
COX4I2-0.328
ASB4-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CCDC6 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CCDC6 protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of CCDC6 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC6 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CCDC6 mRNA21298039
D001151ArsenicArsenic affects the methylation of CCDC6 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CCDC6 protein]26598702
C547126AZM551248AZM551248 results in increased expression of CCDC6 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCDC6 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of CCDC6 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CCDC6 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of CCDC6 mRNA20977926
D002065BuspironeBuspirone results in increased expression of CCDC6 mRNA24136188
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CCDC6 mRNA24763279
C100187chloropicrinchloropicrin results in decreased expression of CCDC6 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in increased expression of CCDC6 mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of CCDC6 mRNA20106945|2556210
D002945CisplatinCisplatin results in decreased expression of CCDC6 mRNA27594783
D004026DieldrinDieldrin results in increased expression of CCDC6 mRNA20438755
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CCDC6 protein23301498
D005047EtoposideCCDC6 results in decreased susceptibility to Etoposide22363533
D005047EtoposideCCDC6 results in increased susceptibility to Etoposide22655027
D005839GentamicinsGentamicins results in increased expression of CCDC6 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CCDC6 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CCDC6 mRNA18951874
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA22839698
C045463leflunomideleflunomide results in increased expression of CCDC6 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of CCDC6 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CCDC6 mRNA"18930950
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CCDC6 promoter]20348232
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCDC6 mRNA23649840
C051752nefazodonenefazodone results in increased expression of CCDC6 mRNA24136188
C012655nimesulidenimesulide results in increased expression of CCDC6 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC6 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of CCDC6 mRNA23892564
D010938Plant OilsPlant Oils results in increased expression of CCDC6 mRNA23370395
D011441PropylthiouracilPropylthiouracil results in decreased expression of CCDC6 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in increased expression of CCDC6 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCDC6 mRNA17517823
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC6 mRNA25729387
D014212TretinoinTretinoin results in increased expression of CCDC6 mRNA20488242
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CCDC6 mRNA"18930950
D014635Valproic AcidValproic Acid affects the expression of CCDC6 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of CCDC6 mRNA17963808
C029297vinylidene chloridevinylidene chloride results in decreased expression of CCDC6 mRNA26682919
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005200structural constituent of cytoskeleton-TAS8058316  
GO:0005515protein binding-IPI17353931  18715871  19156129  23108047  
GO:0017124SH3 domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-IEA-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05216Thyroid cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25773866Clinical and prognostic implications of RET rearrangements in metastatic lung adenocarcinoma patients with malignant pleural effusion. (2015 May)Tsai THLung Cancer
24504365RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. (2014 Mar 18)Tsuta KBr J Cancer
25567908Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)Drilon AClin Cancer Res
23150706RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. (2012 Dec 10)Wang RJ Clin Oncol