Gene: EFHD1

80303
MST133|MSTP133|PP3051|SWS2
EF-hand domain family member D1
protein-coding
2q37.1
Ensembl:ENSG00000115468 MIM:611617 Vega:OTTHUMG00000133263 UniprotKB:Q9BUP0
NG_051251.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.445e-1 (AD)  5.887e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAL0.899
CYP27A10.893
NDRG10.89
PREX10.888
C1orf1980.88
VAMP30.88
PMP220.877
FGFR20.862
GLTP0.86
GSN0.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRSS12-0.512
FREM3-0.497
GPR26-0.492
HS6ST3-0.491
CNTN5-0.482
OR4F29-0.48
KCNH5-0.471
CNGB1-0.456
FBLN7-0.454
OR4F5-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EFHD1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of EFHD1 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFHD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFHD1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EFHD1 mRNA23630614
D000447AldehydesAldehydes results in increased expression of EFHD1 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EFHD1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of EFHD1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EFHD1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EFHD1 mRNA21839799
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EFHD1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of EFHD1 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of EFHD1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of EFHD1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of EFHD1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EFHD1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of EFHD1 mRNA26079696
D002737ChloropreneChloroprene results in decreased expression of EFHD1 mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of EFHD1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of EFHD1 mRNA21356183
D004390ChlorpyrifosChlorpyrifos results in increased expression of EFHD1 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFHD1 gene20938992
C031180chrysenechrysene results in increased expression of EFHD1 mRNA26377693
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EFHD1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of EFHD1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of EFHD1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of EFHD1 mRNA27523638
D003561CytarabineCytarabine results in decreased expression of EFHD1 mRNA21198554
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA27424125
C014347decitabinedecitabine affects the expression of EFHD1 mRNA23300844
D013759DronabinolDronabinol results in decreased expression of EFHD1 mRNA21955143
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EFHD1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EFHD1 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of EFHD1 mRNA28962523
D002945CisplatinCisplatin affects the expression of EFHD1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of EFHD1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of EFHD1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of EFHD1 mRNA18042831
D004237DiuronDiuron results in decreased expression of EFHD1 mRNA25152437
C012301domoic aciddomoic acid results in decreased expression of EFHD1 mRNA18936300
C118739entinostatentinostat results in increased expression of EFHD1 mRNA27188386
D000431EthanolEthanol results in increased expression of EFHD1 mRNA21955143
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EFHD1 mRNA17555576
D005472FluorouracilEFHD1 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFHD1 gene20938992
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA27424125
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of EFHD1 protein]20884965
D019833GenisteinGenistein results in increased expression of EFHD1 protein20884965
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA27424125
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA27424125
D017313FenretinideFenretinide results in decreased expression of EFHD1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EFHD1 mRNA26752646
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of EFHD1 mRNA20843944
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFHD1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EFHD1 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EFHD1 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of EFHD1 mRNA22401849
D009020MorphineMorphine results in decreased expression of EFHD1 mRNA21955143
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFHD1 mRNA"25554681
D009532NickelNickel results in decreased expression of EFHD1 mRNA25583101
D009538NicotineNicotine results in decreased expression of EFHD1 mRNA21955143
D000073878Palm OilPalm Oil results in increased expression of EFHD1 mRNA18042831
C046012pentanalpentanal results in increased expression of EFHD1 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of EFHD1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of EFHD1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of EFHD1 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of EFHD1 mRNA20864642
C005556propionaldehydepropionaldehyde results in increased expression of EFHD1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of EFHD1 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of EFHD1 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EFHD1 mRNA25895662
D012906SmokeSmoke affects the expression of EFHD1 mRNA23693141
C017947sodium arsenitesodium arsenite affects the expression of EFHD1 mRNA29319823
C017947sodium arsenitesodium arsenite affects the methylation of EFHD1 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of EFHD1 protein28918527
D013629TamoxifenTamoxifen affects the expression of EFHD1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EFHD1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFHD1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFHD1 mRNA19465110
D013893ThiramThiram results in increased expression of EFHD1 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of EFHD1 mRNA19464567
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EFHD1 protein27189315
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EFHD1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EFHD1 mRNA28111298
C024746tobacco tartobacco tar results in decreased expression of EFHD1 mRNA19559774
D014635Valproic AcidValproic Acid affects the expression of EFHD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EFHD1 mRNA19101580|2317975
D014640VancomycinVancomycin results in increased expression of EFHD1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EFHD1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of EFHD1 mRNA21126777
C029297vinylidene chloridevinylidene chloride results in decreased expression of EFHD1 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFHD1 mRNA"27188386
C088658zoledronic acidzoledronic acid results in decreased expression of EFHD1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0031175neuron projection development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005743mitochondrial inner membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27189315The human placental proteome is affected by maternal smoking. (2016 Aug)Huuskonen PReprod Toxicol