Gene: NCOA4

8031
ARA70|ELE1|PTC3|RFG
nuclear receptor coactivator 4
protein-coding
10q11.22
Ensembl:ENSG00000266412 MIM:601984 Vega:OTTHUMG00000188314 UniprotKB:Q13772
NG_023372.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.316e-1 (AD)  1.899e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM9SF30.946
TMEM167A0.946
RAB100.943
COPB20.941
XRCC50.938
GSPT10.934
EIF4G20.933
ASAH10.931
CAP10.93
CANX0.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.815
OR4F29-0.792
HMHB1-0.154
MTRNR2L6-0.132
NANOGNB-0.129
C8orf74-0.119
C20orf85-0.119
OR6C74-0.118
MTRNR2L10-0.111
LCE3A-0.109

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of NCOA4 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NCOA4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NCOA4 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NCOA4 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA4 protein modified form]"28751236
C109238acylineacyline results in decreased expression of NCOA4 mRNA17510436
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NCOA4 gene27153756
D013196DihydrotestosteroneNCOA4 promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]11751618
D013196DihydrotestosteroneNCOA4 protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]19815066
C006632arsenic trioxidearsenic trioxide results in increased expression of NCOA4 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NCOA4 mRNA"17331233
D001507BeclomethasoneBeclomethasone results in increased expression of NCOA4 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCOA4 mRNA19770486
D004958EstradiolEstradiol results in increased expression of NCOA4 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[bis(4-hydroxyphenyl)sulfone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA4 protein modified form]28751236
C006780bisphenol Abisphenol A affects the expression of NCOA4 mRNA21786754
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA4 protein modified form]28751236
C006780bisphenol Abisphenol A results in increased expression of NCOA4 mRNA22687993
D019256Cadmium ChlorideNCOA4 promotes the reaction [Cadmium Chloride results in increased activity of AR protein]11751618
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NCOA4 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of NCOA4 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NCOA4 mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of NCOA4 mRNA26352163
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NCOA4 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NCOA4 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of NCOA4 mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of NCOA4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NCOA4 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of NCOA4 mRNA18454173
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene affects the expression of NCOA4 mRNA"26496743
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NCOA4 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of NCOA4 mRNA28302478
D004026DieldrinDieldrin results in increased expression of NCOA4 mRNA28385952
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NCOA4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NCOA4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCOA4 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NCOA4 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of NCOA4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NCOA4 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of NCOA4 mRNA23649840
C039281furanfuran results in increased methylation of NCOA4 gene22079235
D019833GenisteinGenistein results in increased expression of NCOA4 mRNA23019147
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of NCOA4 mRNA22634610
D017313FenretinideFenretinide results in increased expression of NCOA4 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NCOA4 mRNA17183730
C045463leflunomideleflunomide results in increased expression of NCOA4 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NCOA4 gene20938992
D008727MethotrexateMethotrexate affects the expression of NCOA4 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NCOA4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NCOA4 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NCOA4 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NCOA4 mRNA"25554681
D009532NickelNickel affects the expression of NCOA4 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of NCOA4 mRNA]14575637
C029938nickel sulfatenickel sulfate results in decreased expression of NCOA4 mRNA16780908
C087058penconazolepenconazole results in decreased expression of NCOA4 mRNA23811263
D011374ProgesteroneProgesterone results in decreased expression of NCOA4 mRNA18037150
C045950propiconazolepropiconazole results in increased expression of NCOA4 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of NCOA4 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of NCOA4 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA19059307
C059514resveratrolresveratrol results in decreased expression of NCOA4 mRNA10606230
C059514resveratrolresveratrol results in decreased expression of NCOA4 protein10606230
D013629TamoxifenTamoxifen affects the expression of NCOA4 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of NCOA4 mRNA17555576
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of NCOA4 mRNA20189893
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCOA4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NCOA4 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NCOA4 mRNA17942748
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of NCOA4 mRNA]14575637
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of NCOA4 mRNA26562049
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of NCOA4 mRNA27776230
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NCOA4 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NCOA4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-NAS15572661  
GO:0050681androgen receptor binding-NAS15572661  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006622protein targeting to lysosome-IDA25327288  
GO:0006879cellular iron ion homeostasis-IEA-  
GO:0008584male gonad development-TAS8643607  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS8643607  
GO:0044754autolysosome-IDA25327288  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05216Thyroid cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23150706RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. (2012 Dec 10)Wang RJ Clin Oncol