Gene: PDGFD

80310
IEGF|MSTP036|SCDGF-B|SCDGFB
platelet derived growth factor D
protein-coding
11q22.3
Ensembl:ENSG00000170962 MIM:609673 Vega:OTTHUMG00000165953 UniprotKB:Q9GZP0
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.899e-1 (AD)  9.858e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EGFL60.769
IGF10.761
RELN0.751
SLC10A40.744
NDNF0.735
HAPLN10.726
PIP5K1B0.723
CHRNA60.718
PKP20.718
NPR30.71

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOS-0.448
KIF19-0.443
UHRF1-0.417
TGFB3-0.401
CPM-0.391
GPR4-0.379
ITPKB-0.379
PLIN4-0.377
NPIPB6-0.376
CRYAA-0.376

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05139CR002BiotechDrug-InvestigationalTarget
DB05465TandutinibSmall Molecule387867-13-2InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PDGFD mRNA"26377693
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of PDGFD mRNA"20406850
C4711094(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [TGFB1 protein results in decreased expression of PDGFD mRNA]"25280005
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in decreased expression of PDGFD mRNA]"25280005
C496492abrineabrine results in increased expression of PDGFD mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDGFD gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PDGFD mRNA23630614
D001151ArsenicArsenic affects the expression of PDGFD protein24675094
C015001arsenitearsenite results in increased methylation of PDGFD promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDGFD mRNA22610609
D004958EstradiolEstradiol affects the expression of PDGFD mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of PDGFD mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of PDGFD mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PDGFD mRNA28079927
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of PDGFD mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PDGFD mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of PDGFD mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PDGFD mRNA22079614
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PDGFD mRNA20147733
C018475butyraldehydebutyraldehyde results in decreased expression of PDGFD mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDGFD mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFD mRNA20548288|2093899
D016572CyclosporineCyclosporine results in decreased expression of PDGFD mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PDGFD mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of PDGFD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDGFD mRNA28628672
D002945CisplatinCisplatin results in decreased expression of PDGFD mRNA27392435
C058705diethyl malatediethyl malate affects the expression of PDGFD mRNA24814887
D005485FlutamideFlutamide results in increased expression of PDGFD mRNA26485406
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFD mRNA20548288|2093899
C039281furanfuran results in increased expression of PDGFD mRNA27387713
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of PDGFD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDGFD mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDGFD mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of PDGFD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDGFD mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of PDGFD mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFD mRNA26644586
C008261lead acetatelead acetate results in decreased expression of PDGFD mRNA22609695
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]17043664
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFD mRNA20548288|2093899
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDGFD mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDGFD mRNA"26251327
D009532NickelNickel results in decreased expression of PDGFD mRNA25583101
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PDGFD mRNA27029645
C009250sevofluranesevoflurane affects the expression of PDGFD mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDGFD mRNA25895662
D012834SilverSilver results in decreased expression of PDGFD mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of PDGFD mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of PDGFD mRNA22714537
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDGFD mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of PDGFD mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of PDGFD mRNA23557971
C012589trichostatin Atrichostatin A results in decreased expression of PDGFD mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of PDGFD mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PDGFD mRNA19042947
D014415TunicamycinTunicamycin results in increased expression of PDGFD mRNA17127020
D014520UrethaneUrethane results in increased expression of PDGFD mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PDGFD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PDGFD mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PDGFD gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005161platelet-derived growth factor receptor binding-IBA21873635  
GO:0008083growth factor activity-IEA-  
GO:0070851growth factor receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IBA21873635  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0031954positive regulation of protein autophosphorylation-IBA21873635  
GO:0036120cellular response to platelet-derived growth factor stimulus-IEA-  
GO:0043406positive regulation of MAP kinase activity-IBA21873635  
GO:0048008platelet-derived growth factor receptor signaling pathway-IBA21873635  
GO:0048146positive regulation of fibroblast proliferation-IEA-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0051781positive regulation of cell division-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEA-  
GO:0071673positive regulation of smooth muscle cell chemotaxis-IEA-  
GO:0072126positive regulation of glomerular mesangial cell proliferation-IEA-  
GO:2000439positive regulation of monocyte extravasation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res
26362023A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population. (2016)Han JAnn Hum Biol