Gene: TET1

80312
CXXC6|LCX|bA119F7.1
tet methylcytosine dioxygenase 1
protein-coding
10q21.3
Ensembl:ENSG00000138336 MIM:607790 Vega:OTTHUMG00000018359 UniprotKB:Q8NFU7
NC_000010.11
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.674e-1 (AD)  2.133e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAZ2B0.764
AASS0.761
CECR20.747
TROVE20.741
TRPS10.74
ZFHX40.738
ATF70.727
ZBTB370.726
ATAD2B0.726
QSER10.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPAS1-0.368
PHOSPHO1-0.354
LAMB3-0.349
BHLHA9-0.34
NANOS3-0.336
PRR19-0.336
AGMAT-0.332
TTC9B-0.331
MCHR1-0.33
LRRC38-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TET1 mRNA"21394737
C0445782,3,5,6-tetrachlorohydroquinone"TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]"24214992
C0445782,3,5,6-tetrachlorohydroquinone"TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]"24214992
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TET1 mRNA"27188386
C0118655-hydroxymethylcytosine"TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]"24214992
C0118655-hydroxymethylcytosineTET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]24214992
C0118655-hydroxymethylcytosineTET1 protein results in increased chemical synthesis of 5-hydroxymethylcytosine24619417
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TET1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TET1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA]28153600
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TET1 mRNA21632981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TET1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TET1 mRNA24449571
D001205Ascorbic AcidAscorbic Acid affects the activity of TET1 protein24162740
D001280AtrazineAtrazine results in increased expression of TET1 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of TET1 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TET1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TET1 mRNA20106945|2163298
C006780bisphenol Abisphenol A affects the expression of TET1 mRNA27101439
C006780bisphenol Abisphenol A results in decreased expression of TET1 mRNA27474941
C006780bisphenol Abisphenol A results in decreased expression of TET1 protein28030787
C006780bisphenol Abisphenol A affects the expression of TET1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TET1 mRNA27509014
C018475butyraldehydebutyraldehyde results in decreased expression of TET1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of TET1 mRNA25979313
D002703ChloranilTET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]24214992
D002703ChloranilTET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]24214992
D002737ChloropreneChloroprene results in decreased expression of TET1 mRNA23125180
D019327Copper SulfateCopper Sulfate results in decreased activity of TET1 protein26362317
D003471CuprizoneCuprizone results in decreased expression of TET1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of TET1 mRNA20106945|2163298
C000944dicrotophosdicrotophos results in increased expression of TET1 mRNA28302478
D000431EthanolEthanol results in decreased expression of TET1 protein23544149
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TET1 mRNA29097150
D005978GlutathioneGlutathione inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA]28153600
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TET1 mRNA26752646
D008558MelphalanMelphalan results in decreased expression of TET1 mRNA22363485
D008727MethotrexateMethotrexate results in increased expression of TET1 mRNA24449571
D0445035-Methylcytosine"TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased oxidation of 5-Methylcytosine]"24214992
D0445035-MethylcytosineTET1 protein affects the reaction [Chloranil results in increased oxidation of 5-Methylcytosine]24214992
D0445035-MethylcytosineTET1 protein results in increased hydroxylation of 5-Methylcytosine24619417
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TET1 mRNA23179753|2718838
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TET1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TET1 mRNA24810058
C523799MRK 003TET1 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TET1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TET1 mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TET1 mRNA27935865
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA]28153600
D052638Particulate MatterGlutathione inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA]28153600
D052638Particulate MatterParticulate Matter results in increased expression of TET1 mRNA28153600
C046012pentanalpentanal results in decreased expression of TET1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TET1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TET1 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TET1 mRNA27935865
C006253pirinixic acidpirinixic acid results in decreased expression of TET1 mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TET1 mRNA22698814
D011794QuercetinQuercetin results in decreased expression of TET1 mRNA21632981
C031389resorcinolresorcinol results in increased expression of TET1 mRNA22623647
D012715Sesame OilSesame Oil results in increased expression of TET1 mRNA29191790
D012834SilverSilver results in decreased expression of TET1 mRNA26014281
C017947sodium arsenitesodium arsenite affects the reaction [CTCF protein binds to TET1 promoter]29175454
C017947sodium arsenitesodium arsenite results in increased expression of TET1 mRNA29175454
D053260SootSoot results in decreased expression of TET1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TET1 mRNA20106945|2163298
D013849ThimerosalThimerosal results in decreased expression of TET1 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of TET1 mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TET1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of TET1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TET1 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IDA19372391  
GO:0005506iron ion binding-IBA21873635  
GO:0005506iron ion binding-IDA19372391  
GO:0008270zinc ion binding-IEA-  
GO:0070579methylcytosine dioxygenase activity-IBA21873635  
GO:0070579methylcytosine dioxygenase activity-IDA19372391  
GO:0070579methylcytosine dioxygenase activity-IMP21496894  25284789  
GO ID GO Term Qualifier Evidence PubMed
GO:0001826inner cell mass cell differentiation-ISS-  
GO:00062115-methylcytosine catabolic process-IBA21873635  
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006493protein O-linked glycosylation-ISS-  
GO:0008284positive regulation of cell proliferation-IMP25284789  
GO:0019827stem cell population maintenance-ISS-  
GO:0031062positive regulation of histone methylation-IMP25284789  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070989oxidative demethylation-IBA21873635  
GO:0080111DNA demethylation-IBA21873635  
GO:0080111DNA demethylation-IMP21496894  
GO:0090310negative regulation of methylation-dependent chromatin silencing-IMP21496894  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC19372391  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-5221030TET1,2,3 and TDG demethylate DNAIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28249902Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and gammadelta T Cells from Hematopoietic Stem Cells. (2017 May 1)Tie GCancer Res
26300722Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region. (2015)Finegersh AFront Mol Neurosci
29020412Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on delta-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD). (2017 Dec 1)Gatta EInt J Neuropsychopharmacol
29617660Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. (2018 Apr 3)Campbell JDCell Rep