Gene: CPEB4

80315
CPE-BP4|hCPEB-4
cytoplasmic polyadenylation element binding protein 4
protein-coding
5q35.2
Ensembl:ENSG00000113742 MIM:610607 Vega:OTTHUMG00000130541 UniprotKB:Q17RY0
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.874e-1 (AD)  6.692e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM199X0.866
MARCH50.853
FAM135A0.852
SNX130.844
NCOA20.843
ZNF1480.842
TRIM330.841
PDE120.841
ABI10.84
SUZ120.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.647
OR4F29-0.594
SPRR2D-0.248
CSAG1-0.235
PI3-0.226
IFNG-0.218
MUC21-0.215
FCRL1-0.209
SPRR2A-0.201
TMPRSS11B-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CPEB4 mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of CPEB4 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CPEB4 mRNA"19095052
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CPEB4 mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of CPEB4 mRNA"20702594
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPEB4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPEB4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CPEB4 mRNA21420995|2223033
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CPEB4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CPEB4 mRNA21632981|2164198
D001151ArsenicArsenic affects the expression of CPEB4 mRNA18414638
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CPEB4 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of CPEB4 mRNA25929836
D001379AzathioprineAzathioprine results in increased expression of CPEB4 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPEB4 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPEB4 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CPEB4 mRNA"19150397|2001819
C006780bisphenol Abisphenol A results in increased expression of CPEB4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of CPEB4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CPEB4 mRNA29097150
D002220CarbamazepineCarbamazepine affects the expression of CPEB4 mRNA25979313
C007020chlorophyllin"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of CPEB4 mRNA"22485181
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CPEB4 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of CPEB4 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CPEB4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CPEB4 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of CPEB4 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of CPEB4 mRNA20106945|2163298
D013759DronabinolDronabinol results in increased expression of CPEB4 mRNA18454173
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CPEB4 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CPEB4 mRNA17602206
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CPEB4 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of CPEB4 mRNA"22485181
D004237DiuronDiuron results in increased expression of CPEB4 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CPEB4 mRNA"23811387
D000431EthanolEthanol results in decreased expression of CPEB4 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CPEB4 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CPEB4 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CPEB4 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of CPEB4 mRNA23649840
C039281furanfuran results in decreased expression of CPEB4 mRNA25539665
C039281furanfuran results in increased methylation of CPEB4 gene22079235
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPEB4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CPEB4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CPEB4 mRNA22904298
C045463leflunomideleflunomide results in increased expression of CPEB4 mRNA28988120
C008435methyldithiocarbamatemethyldithiocarbamate results in increased expression of CPEB4 mRNA18648088
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CPEB4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CPEB4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CPEB4 mRNA"26251327
D009285NaphthoquinonesNaphthoquinones results in increased expression of CPEB4 mRNA23811387
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CPEB4 mRNA19812364
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CPEB4 mRNA19812364
C502362N-butyrylglucosamineN-butyrylglucosamine results in increased expression of CPEB4 mRNA16142878
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CPEB4 mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CPEB4 mRNA19095052
D010416PentachlorophenolPentachlorophenol affects the expression of CPEB4 mRNA24642059
D010634PhenobarbitalPhenobarbital affects the expression of CPEB4 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPEB4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CPEB4 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CPEB4 mRNA17426115|1830175
D010938Plant OilsPlant Oils results in increased expression of CPEB4 mRNA23370395
C045950propiconazolepropiconazole results in decreased expression of CPEB4 mRNA21278054
D012822Silicon DioxideSilicon Dioxide results in increased expression of CPEB4 mRNA19073995
D012834SilverSilver results in increased expression of CPEB4 mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of CPEB4 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of CPEB4 mRNA27862939
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CPEB4 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CPEB4 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CPEB4 mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CPEB4 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CPEB4 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPEB4 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CPEB4 mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of CPEB4 mRNA23228038
D014212TretinoinTretinoin results in increased expression of CPEB4 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of CPEB4 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of CPEB4 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CPEB4 mRNA"26179874
D014520UrethaneUrethane results in increased expression of CPEB4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of CPEB4 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CPEB4 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of CPEB4 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of CPEB4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-IBA21873635  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003730mRNA 3'-UTR binding-IBA21873635  
GO:0005515protein binding-IPI21336257  
GO:0008135translation factor activity, RNA binding-IBA21873635  
GO:0043022ribosome binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-ISS-  
GO:0006412translation-IEA-  
GO:0035235ionotropic glutamate receptor signaling pathway-ISS-  
GO:0036294cellular response to decreased oxygen levels-ISS-  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0071230cellular response to amino acid stimulus-ISS-  
GO:2000766negative regulation of cytoplasmic translation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20639532  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA20639532  
GO:0005737cytoplasm-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0014069postsynaptic density-ISS-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-ISS-  
GO:0030426growth cone-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043197dendritic spine-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:1990124messenger ribonucleoprotein complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27113098CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)Wu YYJ Formos Med Assoc