Gene: CEP70

80321
BITE
centrosomal protein 70
protein-coding
3q22.3
Ensembl:ENSG00000114107 MIM:614310 Vega:OTTHUMG00000159891 UniprotKB:Q8NHQ1
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.426e-1 (AD)  5.220e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs529615chr3:138594992 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNPAT0.886
BUB30.885
SMARCA10.875
UBA30.867
TBC1D150.866
EIF3M0.865
TMEM167B0.864
TMEM590.861
ALDH3A20.86
ZNF3020.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.618
OR4F29-0.589
PTGDR2-0.266
TTLL10-0.261
RNF223-0.252
RERGL-0.245
MTRNR2L10-0.237
MTRNR2L6-0.232
MTRNR2L2-0.229
KLRB1-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CEP70 mRNA16788091
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CEP70 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CEP70 mRNA22230336|2669055
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CEP70 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CEP70 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of CEP70 mRNA21757418
C006632arsenic trioxidearsenic trioxide results in increased expression of CEP70 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of CEP70 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CEP70 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of CEP70 exon26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CEP70 mRNA21632981|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CEP70 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of CEP70 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of CEP70 gene28505145
C584509C646 compoundC646 compound results in increased expression of CEP70 mRNA26191083
D003010ClorgylineClorgyline results in increased expression of CEP70 mRNA19691856
D019327Copper SulfateCopper Sulfate results in decreased expression of CEP70 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CEP70 mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of CEP70 mRNA28302478
D004026DieldrinDieldrin results in increased expression of CEP70 mRNA20438755
C118739entinostatentinostat results in decreased expression of CEP70 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CEP70 mRNA22079256
C039281furanfuran results in increased expression of CEP70 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of CEP70 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of CEP70 mRNA26191083
D007649KetamineKetamine results in decreased expression of CEP70 mRNA20080153
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CEP70 promoter]20348232
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CEP70 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CEP70 mRNA"25554681
D009532NickelNickel results in decreased expression of CEP70 mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CEP70 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CEP70 mRNA25729387
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CEP70 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of CEP70 mRNA19136022
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CEP70 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of CEP70 mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of CEP70 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CEP70 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CEP70 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CEP70 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of CEP70 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of CEP70 mRNA21632981
D012834SilverSilver results in increased expression of CEP70 mRNA27131904
C016766sulforafansulforafan results in decreased expression of CEP70 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEP70 mRNA26232522
D013853ThioacetamideThioacetamide results in increased expression of CEP70 mRNA22659510|2341159
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CEP70 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CEP70 mRNA25729387
D014212TretinoinTretinoin results in increased expression of CEP70 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CEP70 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of CEP70 mRNA27188386
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CEP70 mRNA"26179874
D014520UrethaneUrethane results in increased expression of CEP70 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CEP70 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CEP70 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CEP70 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of CEP70 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CEP70 gene25560391
C111237vorinostatvorinostat results in increased expression of CEP70 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  16713569  19060904  21900206  23455924  25416956  
25910212  26871637  27107012  27107014  
GO:0042802identical protein binding-IPI25416956  27107012  
GO:0043015gamma-tubulin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0070507regulation of microtubule cytoskeleton organization-IEA-  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005813centrosome-IDA21399614  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal