Gene: ADAM33

80332
C20orf153|DJ964F7.1
ADAM metallopeptidase domain 33
protein-coding
20p13
Ensembl:ENSG00000149451 MIM:607114 Vega:OTTHUMG00000031758 UniprotKB:Q9BZ11
NC_000020.11
PubMed
0   ANCO-SNPs
ND
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.799e-1 (AD)  5.441e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08424491chr20:3656074ADAM33Gene body5.767e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC19A10.68
ISYNA10.646
COL5A30.63
HGFAC0.612
SLC6A120.602
MFGE80.596
ADAMTS100.595
ITIH50.595
TMC40.587
RGL20.583

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA3D-0.364
ADAMTS18-0.363
SLC15A5-0.354
ZNF367-0.337
SMIM6-0.331
C14orf39-0.331
CDH19-0.327
GREM1-0.326
NPFFR2-0.314
NHLH2-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of ADAM33 mRNA22230336
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ADAM33 mRNA24449571
D001241AspirinADAM33 SNP affects the susceptibility to Aspirin17061022
D001280AtrazineAtrazine results in decreased expression of ADAM33 mRNA25929836
D001542BenomylBenomyl results in increased expression of ADAM33 protein27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein]27784618
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADAM33 mRNA]22228805
C031180chrysenechrysene results in increased expression of ADAM33 mRNA26377693
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADAM33 mRNA24893172
D002117CalcitriolCalcitriol results in decreased expression of ADAM33 mRNA26485663
D004237DiuronDiuron results in decreased expression of ADAM33 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ADAM33 mRNA17557909
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ADAM33 mRNA"24972896
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ADAM33 mRNA24810058
D009532NickelNickel results in decreased expression of ADAM33 mRNA24768652|2558310
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAM33 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ADAM33 mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in increased expression of ADAM33 mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of ADAM33 mRNA26079696
C009277sodium arsenatesodium arsenate results in increased expression of ADAM33 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADAM33 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of ADAM33 mRNA23557971
D014635Valproic AcidValproic Acid results in increased methylation of ADAM33 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-NAS11814695  
GO:0008270zinc ion binding-NAS11814695  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-NAS11814695  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-NAS11814695  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy
20156753ADAM33 gene polymorphisms in chronic obstructive pulmonary disease. (2009 Dec 7)Pabst SEur J Med Res
23861802ADAM33 gene polymorphisms and mortality. A prospective cohort study. (2013)Figarska SMPLoS One
24422987Polymorphisms in a disintegrin and metalloprotease 33 gene and the risk of chronic obstructive pulmonary disease: a meta-analysis. (2014 Apr)Zhang RRespirology
22583515ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2012 Jul)Miyake YInt J Tuberc Lung Dis
25721048Genetic variants in TNFalpha, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. (2016)Yucesoy BJ Immunotoxicol
22349453ADAM33 genetic polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2012 Apr)Miyake YHum Immunol
25983406A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India. (2015 May-Jun)Shah SLung India
20513247Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. (2010 Jun 1)Kim JYBMC Pulm Med
22888638[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. (2012 May-Jun)Korytina GFMol Biol (Mosk)
22209925Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications. (2011 Dec)Mocchegiani ECurr Opin Pulm Med
18188020Risk factors associated with irreversible airflow limitation in asthma. (2008 Feb)ten Brinke ACurr Opin Allergy Clin Immunol