Gene: PNPLA3

80339
ADPN|C22orf20|iPLA(2)epsilon
patatin like phospholipase domain containing 3
protein-coding
22q13.31
Ensembl:ENSG00000100344 MIM:609567 Vega:OTTHUMG00000150555 UniprotKB:Q9NST1
NG_008631.1
PubMed
0   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.154e-1 (AD)  4.591e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMGCS10.693
CYP51A10.649
C6orf2230.643
PFKFB20.622
PLA2G30.607
MSMO10.582
EFR3B0.573
NAV20.566
VWCE0.563
ADRA1A0.559

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MIA-0.314
C4orf47-0.307
IFNA2-0.306
OR7C1-0.291
CTNNA3-0.281
ANKRD23-0.27
NPIPB6-0.267
C7orf61-0.266
KLRK1-0.265
HIST1H1T-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PNPLA3 mRNA"27180240|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PNPLA3 mRNA]"27180240
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPLA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNPLA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPLA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPLA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNPLA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPLA3 mRNA"27188386
C4750936-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime"6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of PNPLA3 mRNA"27180240
D000082AcetaminophenAcetaminophen results in decreased expression of PNPLA3 mRNA21420995|2223033
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Dietary Fats results in increased expression of PNPLA3 mRNA]21051528
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PNPLA3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PNPLA3 mRNA21641981|2715375
C015001arsenitearsenite results in increased expression of PNPLA3 mRNA23974009
D001379AzathioprineAzathioprine results in decreased expression of PNPLA3 mRNA22623647
D001507BeclomethasoneBeclomethasone results in increased expression of PNPLA3 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PNPLA3 mRNA20064835|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PNPLA3 mRNA21964900
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PNPLA3 mRNA25566086
D004958EstradiolEstradiol results in decreased expression of PNPLA3 mRNA20106945
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PNPLA3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PNPLA3 mRNA21932408|2847654
C006780bisphenol Abisphenol A results in decreased expression of PNPLA3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PNPLA3 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PNPLA3 mRNA28628672
D002104CadmiumCadmium results in increased expression of PNPLA3 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PNPLA3 mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PNPLA3 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of PNPLA3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PNPLA3 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PNPLA3 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PNPLA3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PNPLA3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PNPLA3 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in decreased expression of PNPLA3 mRNA23656968
D002945CisplatinCisplatin results in increased expression of PNPLA3 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PNPLA3 mRNA28302478
D004041Dietary FatsAcetylcysteine inhibits the reaction [Dietary Fats results in increased expression of PNPLA3 mRNA]21051528
D004041Dietary FatsDietary Fats results in increased expression of PNPLA3 mRNA21051528
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PNPLA3 mRNA24535843
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PNPLA3 mRNA"20184727
C118739entinostatentinostat results in increased expression of PNPLA3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPLA3 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PNPLA3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PNPLA3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PNPLA3 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of PNPLA3 mRNA28189721
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of PNPLA3 mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PNPLA3 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of PNPLA3 mRNA]"23333450
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PNPLA3 gene20938992
C039281furanfuran results in increased expression of PNPLA3 mRNA24183702
C412815GW 4064GW 4064 results in increased expression of PNPLA3 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of PNPLA3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PNPLA3 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PNPLA3 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PNPLA3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PNPLA3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PNPLA3 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of PNPLA3 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PNPLA3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PNPLA3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PNPLA3 mRNA28628672
C410337K 7174K 7174 results in decreased expression of PNPLA3 mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PNPLA3 gene20938992
D008727MethotrexateMethotrexate results in increased expression of PNPLA3 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PNPLA3 mRNA23179753|2718838
D009020MorphineMorphine results in increased expression of PNPLA3 mRNA20144693
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PNPLA3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PNPLA3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PNPLA3 mRNA"25620056
D009532NickelNickel results in decreased expression of PNPLA3 mRNA24768652|2558310
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of PNPLA3 mRNA19326039|2018472
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of PNPLA3 mRNA"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of PNPLA3 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of PNPLA3 mRNA]"23333450
C016030pantogabpantogab results in decreased expression of PNPLA3 mRNA17379144
D010634PhenobarbitalPhenobarbital results in increased expression of PNPLA3 mRNA27180240
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PNPLA3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PNPLA3 mRNA19482888|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNPLA3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PNPLA3 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of PNPLA3 mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PNPLA3 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of PNPLA3 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of PNPLA3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PNPLA3 mRNA24780913
C030984pyrenepyrene results in decreased expression of PNPLA3 mRNA23656968
D011794QuercetinQuercetin results in decreased expression of PNPLA3 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of PNPLA3 mRNA17032037
D015474IsotretinoinIsotretinoin results in decreased expression of PNPLA3 mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of PNPLA3 mRNA17215164
D012431RutinRutin results in decreased expression of PNPLA3 mRNA17032037
D012906SmokeSmoke results in increased expression of PNPLA3 mRNA21095227
C016104sodium bichromatesodium bichromate affects the expression of PNPLA3 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of PNPLA3 mRNA25993096
D013629TamoxifenTamoxifen affects the expression of PNPLA3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PNPLA3 mRNA20106945|2623829
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PNPLA3 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PNPLA3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PNPLA3 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PNPLA3 mRNA22539624|2297716
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PNPLA3 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PNPLA3 mRNA21724226|2323856
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PNPLA3 mRNA21215274
D013849ThimerosalThimerosal results in decreased expression of PNPLA3 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of PNPLA3 mRNA23557971
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of PNPLA3 mRNA]23333450
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of PNPLA3 mRNA]23333450
C423915TO-901317TO-901317 results in increased expression of PNPLA3 mRNA23333450
D014241TrichloroethyleneTrichloroethylene results in increased expression of PNPLA3 mRNA25549359
C012589trichostatin Atrichostatin A results in increased expression of PNPLA3 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PNPLA3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PNPLA3 mRNA12953171
D014520UrethaneUrethane results in decreased expression of PNPLA3 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of PNPLA3 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PNPLA3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PNPLA3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PNPLA3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of PNPLA3 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of PNPLA3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PNPLA3 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of PNPLA3 mRNA24489787
D014638VanadatesVanadates results in increased expression of PNPLA3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PNPLA3 gene25560391
C111237vorinostatvorinostat results in decreased expression of PNPLA3 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IBA21873635  
GO:0004465lipoprotein lipase activity-TAS-  
GO:0004623phospholipase A2 activity-IDA15364929  
GO:0004806triglyceride lipase activity-IBA21873635  
GO:0004806triglyceride lipase activity-IDA15364929  22560221  
GO:0004806triglyceride lipase activity-TAS-  
GO:0016411acylglycerol O-acyltransferase activity-TAS-  
GO:0035727lysophosphatidic acid binding-IDA22560221  
GO:0036042long-chain fatty acyl-CoA binding-IDA22560221  
GO:0042171lysophosphatidic acid acyltransferase activity-IDA22560221  
GO:0051264mono-olein transacylation activity-IDA15364929  
GO:0051265diolein transacylation activity-IDA15364929  
GO ID GO Term Qualifier Evidence PubMed
GO:0001676long-chain fatty acid metabolic process-IDA22560221  
GO:0006650glycerophospholipid metabolic process-IDA22560221  
GO:0006654phosphatidic acid biosynthetic process-IDA22560221  
GO:0019432triglyceride biosynthetic process-IDA15364929  22560221  
GO:0019433triglyceride catabolic process-IBA21873635  
GO:0019433triglyceride catabolic process-IDA15364929  22560221  
GO:0019433triglyceride catabolic process-IEA-  
GO:0034389lipid particle organization-IMP23398201  
GO:0036153triglyceride acyl-chain remodeling-IDA24511104  
GO:0036155acylglycerol acyl-chain remodeling-TAS-  
GO:0055088lipid homeostasis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005811lipid droplet-IBA21873635  
GO:0005811lipid droplet-IDA22560221  23398201  
GO:0016020membrane-IBA21873635  
GO:0016020membrane-IDA22560221  
GO:0016020membrane-ISS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482883Acyl chain remodeling of DAG and TAGTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27235307Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study. (2016 Oct)Suomela EJ Hepatol
28161471Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis. (2017 Jul)Atkinson SRJ Hepatol
20585554On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study. (2010 Jun 17)Pare GPLoS Genet
19946271Variant in PNPLA3 is associated with alcoholic liver disease. (2010 Jan)Tian CNat Genet
25290313Association between the PNPLA3 I148M polymorphism and non-alcoholic fatty liver disease in the Uygur and Han ethnic groups of northwestern China. (2014)Zhang YPLoS One
24114820Genetic factors affecting susceptibility to alcoholic liver disease in an Indian population. (2013 Nov-Dec)Dutta AKAnn Hepatol
29242078Reply to: "The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort". (2017 Dec 11)Atkinson SRJ Hepatol
27575312The genetics of alcohol dependence and alcohol-related liver disease. (2017 Jan)Stickel FJ Hepatol
27627804Epicardial Adipose Tissue (EAT) Thickness Is Associated with Cardiovascular and Liver Damage in Nonalcoholic Fatty Liver Disease. (2016)Fracanzani ALPLoS One
28617615Association between PNPLA3 gene polymorphisms and risk of hepatitis B virus-related hepatocellular carcinoma in Han population in China:a case-control study. (2017 Oct)Gao XScand J Gastroenterol
27320325Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis. (2016 Dec)Liangpunsakul SClin Gastroenterol Hepatol