Gene: BPIFB2

80341
BPIL1|C20orf184|LPLUNC2|RYSR|dJ726C3.2
BPI fold containing family B member 2
protein-coding
20q11.21
Ensembl:ENSG00000078898 MIM:614108 Vega:OTTHUMG00000032232 UniprotKB:Q8N4F0
NG_016714.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.204e-1 (AD)  3.741e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6120085chr20:33010975 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC70.743
ZG16B0.691
PIP0.666
CRISP30.56
C11orf400.46
PIGR0.436
CYP17A10.426
CRP0.422
STATH0.419
ACPP0.402

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMILIN3-0.274
C17orf100-0.26
HAS3-0.241
POLR3B-0.236
DRGX-0.234
ZNF407-0.234
CDKL1-0.231
SFTPC-0.23
EPB42-0.229
CPO-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of BPIFB2 mRNA"21346803
D020106AcrylamideAcrylamide results in increased expression of BPIFB2 mRNA28959563
D000667AmpicillinAmpicillin results in increased expression of BPIFB2 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BPIFB2 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased methylation of BPIFB2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of BPIFB2 mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of BPIFB2 mRNA25562108
D003976DiazinonDiazinon results in increased methylation of BPIFB2 gene22964155
C000944dicrotophosdicrotophos results in increased expression of BPIFB2 mRNA28302478
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of BPIFB2 mRNA17183730
D011794QuercetinQuercetin affects the expression of BPIFB2 mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of BPIFB2 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BPIFB2 mRNA20106945|2163298
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of BPIFB2 mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of BPIFB2 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BPIFB2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0019730antimicrobial humoral response-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal