Gene: SEL1L2

80343
C20orf50|sel-1L2
SEL1L2, ERAD E3 ligase adaptor subunit
protein-coding
20p12.1
Ensembl:ENSG00000101251 MIM:614289 Vega:OTTHUMG00000031910 UniprotKB:Q5TEA6
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.237e-1 (AD)  8.222e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2073290chr20:13849491 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALT50.51
C11orf450.496
MAT1A0.493
MYO3A0.488
GPHA20.479
DRD30.474
TNFRSF80.473
ANKRD34B0.472
TTC220.468
GPR1010.465

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1A1-0.234
IL9-0.216
HBD-0.215
PADI6-0.214
ANP32C-0.213
GRHL2-0.205
RNF182-0.205
C19orf18-0.202
IGFL1-0.202
RNF148-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of SEL1L2 mRNA28959563
C006780bisphenol Abisphenol A results in decreased expression of SEL1L2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SEL1L2 gene28505145
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SEL1L2 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of SEL1L2 mRNA25016146
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEL1L2 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SEL1L2 gene27618143

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal