Gene info: ID 805

Gene: CALM2

GENE ID: 805

Synonyms: CAMII|LQT15|PHKD|PHKD2|caM

Description: calmodulin 2

Gene type: protein-coding

Location: 2p21

dbXrefs: Ensembl:ENSG00000143933 MIM:114182 Vega:OTTHUMG00000128850 UniprotKB:P0DP24

RefSeq: NG_042065.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.359e-1 (AD) 8.787e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AP3S1	0.967
MORF4L1	0.966
BEX4	0.964
PEBP1	0.964
NGRN	0.957
BRK1	0.956
EIF4A2	0.955
MRFAP1L1	0.955
PPIA	0.955
EMC4	0.954

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.869
OR4F29	-0.857
KCNJ15	-0.267
FOLR3	-0.258
RUNX3	-0.25
TFPI2	-0.246
CXCR2	-0.24
SIX1	-0.237
MTRNR2L6	-0.236
MAGEA12	-0.233

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11093	Calcium Citrate	Small Molecule	813-94-5	Approved	Target
DB11348	Calcium Phosphate	Small Molecule	10103-46-5	Approved	Target

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CALM2 mRNA"	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CALM2 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CALM2 mRNA]	28655636
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA]"	11179685
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CALM2 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CALM2 mRNA	16483693
D000661	Amphetamine	Amphetamine affects the expression of CALM2 mRNA	10854758
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CALM2 mRNA	25339124
C015001	arsenite	arsenite results in increased methylation of CALM2 promoter	23974009
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CALM2 mRNA	22228805
D004958	Estradiol	"3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA]"	11179685
D004958	Estradiol	Estradiol results in decreased expression of CALM2 mRNA	11179685
D004958	Estradiol	Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA]	11179685
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of CALM2 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of CALM2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased methylation of CALM2 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of CALM2 mRNA	18958704
C515564	bromovanin	bromovanin results in increased expression of CALM2 protein	21419150
D002065	Buspirone	Buspirone results in decreased expression of CALM2 mRNA	24136188
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of CALM2 mRNA	16122865
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CALM2 mRNA	25035189
D019256	Cadmium Chloride	Selenium inhibits the reaction [Cadmium Chloride results in decreased expression of CALM2 mRNA]	25035189
D002186	Cannabinoids	Cannabinoids results in decreased expression of CALM2 mRNA	17205118
C026690	cerous chloride	cerous chloride results in increased expression of CALM2 mRNA	23573234
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CALM2 mRNA	23650126
C100187	chloropicrin	chloropicrin results in increased expression of CALM2 mRNA	26352163
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CALM2 mRNA	17602206
D003024	Clozapine	Clozapine results in increased expression of CALM2 mRNA	19289156
D003042	Cocaine	Cocaine results in decreased expression of CALM2 mRNA	17205118
D003300	Copper	Copper results in decreased expression of CALM2 mRNA	25646894
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CALM2 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of CALM2 mRNA	26577399
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of CALM2 mRNA	17654400
C009160	cyclonite	cyclonite affects the expression of CALM2 mRNA	19417177
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of CALM2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of CALM2 mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of CALM2 mRNA	28302478
D004026	Dieldrin	Dieldrin affects the expression of CALM2 mRNA	22546817
D004041	Dietary Fats	Dietary Fats results in increased expression of CALM2 mRNA	18042831
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CALM2 mRNA	17602206
D004237	Diuron	Diuron results in increased expression of CALM2 mRNA	21551480
D000431	Ethanol	Ethanol results in decreased expression of CALM2 mRNA	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CALM2 protein	20381887
C056933	fumonisin B1	fumonisin B1 results in increased expression of CALM2 mRNA	16221962
D005839	Gentamicins	Gentamicins results in increased expression of CALM2 mRNA	22061828
D005947	Glucose	CALM2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]	21124846
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of CALM2 mRNA	22634610
D006220	Haloperidol	Haloperidol results in increased expression of CALM2 mRNA	19289156
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CALM2 mRNA	20044591
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CALM2 mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of CALM2 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of CALM2 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of CALM2 mRNA	24086573
D008344	Maneb	[Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA	18386188
D008727	Methotrexate	Methotrexate results in increased expression of CALM2 mRNA	21678067
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of CALM2 mRNA]	27264040
C568376	MT19c compound	MT19c compound results in increased expression of CALM2 mRNA	21781307
C051752	nefazodone	nefazodone results in decreased expression of CALM2 mRNA	24136188
C022838	nickel chloride	nickel chloride affects the expression of CALM2 mRNA	22546817
C012655	nimesulide	nimesulide results in decreased expression of CALM2 mRNA	24136188
D005996	Nitroglycerin	Nitroglycerin results in increased expression of CALM2 mRNA	12102619
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of CALM2 mRNA	23561263
D010100	Oxygen	CALM2 protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]	21124846
D000073878	Palm Oil	Palm Oil results in increased expression of CALM2 mRNA	18042831
D010269	Paraquat	[Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA	18386188
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CALM2 mRNA]	28655636
D052638	Particulate Matter	Particulate Matter results in decreased expression of CALM2 mRNA	28412507\|2865563
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CALM2 mRNA	19756518
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CALM2 mRNA	19756518
D010622	Phencyclidine	Phencyclidine results in decreased expression of CALM2 mRNA	17205118
D010634	Phenobarbital	Phenobarbital affects the expression of CALM2 mRNA	19159669
D010672	Phenytoin	Phenytoin results in decreased expression of CALM2 mRNA	14741686
D010936	Plant Extracts	Plant Extracts results in increased expression of CALM2 mRNA	23557933
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of CALM2 mRNA]	27264040
D011374	Progesterone	Progesterone results in decreased expression of CALM2 mRNA	27264040
D018967	Risperidone	Risperidone results in increased expression of CALM2 mRNA	19289156
D012643	Selenium	Selenium inhibits the reaction [Cadmium Chloride results in decreased expression of CALM2 mRNA]	25035189
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CALM2 mRNA	21340527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA]	11179685
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CALM2 mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CALM2 mRNA	25613284
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CALM2 mRNA"	19682533
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of CALM2 gene	27618143
C012589	trichostatin A	trichostatin A results in increased expression of CALM2 mRNA	15901671
D014415	Tunicamycin	Tunicamycin results in decreased expression of CALM2 mRNA	22378314
D014501	Uranium	Uranium affects the expression of CALM2 mRNA	15672453
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of CALM2 mRNA	19654044
C005460	uranyl acetate	uranyl acetate affects the expression of CALM2 mRNA	15672453
D014635	Valproic Acid	Valproic Acid results in decreased methylation of CALM2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CALM2 mRNA	19101580
D014635	Valproic Acid	Valproic Acid results in increased expression of CALM2 mRNA	15901671
D001335	Vehicle Emissions	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CALM2 mRNA]	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CALM2 mRNA	28655636
D014750	Vincristine	Vincristine results in decreased expression of CALM2 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	IDA	7607248 8631777 11807546 23040497 26164367 26969752 27516456
GO:0005515	protein binding	-	IPI	3111527 10692436 15140941 16760425 19855925 21299499
GO:0008179	adenylate cyclase binding	-	IPI	11807546
GO:0019855	calcium channel inhibitor activity	-	IDA	26969752
GO:0019901	protein kinase binding	-	IPI	20668654
GO:0019904	protein domain specific binding	-	IPI	11984006
GO:0031432	titin binding	-	IPI	7607248
GO:0031997	N-terminal myristoylation domain binding	-	IPI	15632291
GO:0043539	protein serine/threonine kinase activator activity	-	TAS	20668654
GO:0044325	ion channel binding	-	IPI	21167176 23040497
GO:0072542	protein phosphatase activator activity	-	IDA	8631777
GO:0097718	disordered domain specific binding	-	IPI	19855925

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002027	regulation of heart rate	-	IMP	23040497
GO:0005513	detection of calcium ion	-	IMP	23040497
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	10899953
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	-	TAS	20668654
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	-	TAS	20668654
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	-	IDA	20226167
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	-	IC	-
GO:0021762	substantia nigra development	-	HEP	22926577
GO:0031954	positive regulation of protein autophosphorylation	-	TAS	20668654
GO:0032465	regulation of cytokinesis	-	IMP	16760425
GO:0032516	positive regulation of phosphoprotein phosphatase activity	-	IDA	8631777
GO:0035307	positive regulation of protein dephosphorylation	-	IDA	8631777
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	-	IDA	8631777
GO:0051592	response to calcium ion	-	IDA	7607248
GO:0055117	regulation of cardiac muscle contraction	-	IMP	23040497
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	-	IDA	26164367
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	-	IDA	20226167
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	TAS	20668654
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	-	IC	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000922	spindle pole	-	IDA	16760425
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IDA	27165696
GO:0005737	cytoplasm	-	TAS	10899953
GO:0005813	centrosome	-	IDA	16760425
GO:0005876	spindle microtubule	-	IDA	16760425
GO:0005886	plasma membrane	-	TAS	10899953
GO:0030017	sarcomere	-	IDA	20226167
GO:0031982	vesicle	-	HDA	19190083
GO:0032991	protein-containing complex	-	IDA	19855925
GO:0034704	calcium channel complex	-	IDA	23040497
GO:1902494	catalytic complex	-	IDA	11807546

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa04114	Oocyte meiosis
hsa04270	Vascular smooth muscle contraction
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04740	Olfactory transduction
hsa04744	Phototransduction
hsa04910	Insulin signaling pathway
hsa04912	GnRH signaling pathway
hsa04916	Melanogenesis
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa05010	Alzheimer's disease
hsa05214	Glioma

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	TAS
R-HSA-111885	Opioid Signalling	IEA
R-HSA-111931	PKA-mediated phosphorylation of CREB	TAS
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	TAS
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	IEA
R-HSA-111933	Calmodulin induced events	TAS
R-HSA-111933	Calmodulin induced events	IEA
R-HSA-111957	Cam-PDE 1 activation	TAS
R-HSA-111996	Ca-dependent events	TAS
R-HSA-111996	Ca-dependent events	IEA
R-HSA-111997	CaM pathway	TAS
R-HSA-111997	CaM pathway	IEA
R-HSA-112040	G-protein mediated events	TAS
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112043	PLC beta mediated events	TAS
R-HSA-112043	PLC beta mediated events	IEA
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-114608	Platelet degranulation	TAS
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	TAS
R-HSA-1483249	Inositol phosphate metabolism	TAS
R-HSA-1489509	DAG and IP3 signaling	TAS
R-HSA-1489509	DAG and IP3 signaling	IEA
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163615	PKA activation	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-180024	DARPP-32 events	IEA
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	TAS
R-HSA-194138	Signaling by VEGF	IEA
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194315	Signaling by Rho GTPases	IEA
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-195258	RHO GTPase Effectors	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-196854	Metabolism of vitamins and cofactors	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-202131	Metabolism of nitric oxide	TAS
R-HSA-2025928	Calcineurin activates NFAT	TAS
R-HSA-2025928	Calcineurin activates NFAT	IEA
R-HSA-203615	eNOS activation	TAS
R-HSA-203765	eNOS activation and regulation	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	IEA
R-HSA-2187338	Visual phototransduction	IEA
R-HSA-2187338	Visual phototransduction	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2514856	The phototransduction cascade	IEA
R-HSA-2514856	The phototransduction cascade	TAS
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	IEA
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	TAS
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-2871809	FCERI mediated Ca+2 mobilization	TAS
R-HSA-2871809	FCERI mediated Ca+2 mobilization	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-397014	Muscle contraction	TAS
R-HSA-397014	Muscle contraction	IEA
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418359	Reduction of cytosolic Ca++ levels	TAS
R-HSA-418360	Platelet calcium homeostasis	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-425561	Sodium/Calcium exchangers	TAS
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-438064	Post NMDA receptor activation events	IEA
R-HSA-4420097	VEGFA-VEGFR2 Pathway	IEA
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	TAS
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	IEA
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442745	Activation of CaMK IV	TAS
R-HSA-442745	Activation of CaMK IV	IEA
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	IEA
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	TAS
R-HSA-445355	Smooth Muscle Contraction	IEA
R-HSA-445355	Smooth Muscle Contraction	TAS
R-HSA-451306	Ionotropic activity of kainate receptors	TAS
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	TAS
R-HSA-451326	Activation of kainate receptors upon glutamate binding	TAS
R-HSA-5210891	Uptake and function of anthrax toxins	TAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	TAS
R-HSA-5218921	VEGFR2 mediated cell proliferation	IEA
R-HSA-5339562	Uptake and actions of bacterial toxins	TAS
R-HSA-5576891	Cardiac conduction	TAS
R-HSA-5576892	Phase 0 - rapid depolarisation	TAS
R-HSA-5578775	Ion homeostasis	TAS
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	TAS
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	IEA
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5607764	CLEC7A (Dectin-1) signaling	IEA
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	IEA
R-HSA-5626467	RHO GTPases activate IQGAPs	TAS
R-HSA-5627123	RHO GTPases activate PAKs	TAS
R-HSA-5627123	RHO GTPases activate PAKs	IEA
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-5663205	Infectious disease	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-70221	Glycogen breakdown (glycogenolysis)	TAS
R-HSA-70221	Glycogen breakdown (glycogenolysis)	IEA
R-HSA-71387	Metabolism of carbohydrates	TAS
R-HSA-71387	Metabolism of carbohydrates	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS
R-HSA-8876725	Protein methylation	TAS
R-HSA-8978934	Metabolism of cofactors	TAS
R-HSA-8982491	Glycogen metabolism	TAS
R-HSA-8982491	Glycogen metabolism	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-936837	Ion transport by P-type ATPases	TAS
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21546767	Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (2011)	Murea M	Am J Nephrol