Gene: SLC19A3

80704
BBGD|THMD2|THTR2
solute carrier family 19 member 3
protein-coding
2q36.3
Ensembl:ENSG00000135917 MIM:606152 Vega:OTTHUMG00000133185 UniprotKB:Q9BZV2
NG_016359.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.873e-1 (AD)  5.686e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLI10.88
FOXC10.871
CASP100.87
MECOM0.865
EMCN0.859
TGFBR20.857
CYYR10.855
RNF144B0.846
ABCB10.834
CFI0.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.51
TMEM121-0.503
CORT-0.498
SPEF1-0.495
CPLX3-0.495
CRH-0.488
HAS1-0.482
KCNIP3-0.48
MAGIX-0.473
SPATA2L-0.473

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SLC19A3 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC19A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC19A3 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 mRNA24244374
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 protein24244374
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 protein] which results in decreased uptake of Thiamine24244374
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC19A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC19A3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC19A3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC19A3 mRNA17562736
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC19A3 mRNA21757418
C547126AZM551248AZM551248 results in decreased expression of SLC19A3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC19A3 mRNA20106945
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SLC19A3 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of SLC19A3 mRNA27685785
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of SLC19A3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC19A3 mRNA25181051
D002104CadmiumCadmium results in decreased expression of SLC19A3 mRNA21120746
D016572CyclosporineCyclosporine results in decreased expression of SLC19A3 mRNA20106945|2798913
D002945CisplatinCisplatin results in decreased expression of SLC19A3 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC19A3 mRNA26924002
D015118Eicosapentaenoic AcidPPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of SLC19A3 mRNA]18489776
C118739entinostatentinostat results in increased expression of SLC19A3 mRNA27188386
D000431EthanolEthanol results in decreased expression of SLC19A3 mRNA28986285
C412815GW 4064GW 4064 results in increased expression of SLC19A3 mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLC19A3 mRNA20044591
C008261lead acetatelead acetate results in increased expression of SLC19A3 mRNA22641619
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLC19A3 mRNA16507785
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC19A3 mRNA26924002
D009532NickelNickel results in decreased expression of SLC19A3 mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC19A3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SLC19A3 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of SLC19A3 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC19A3 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC19A3 mRNA24780913
D011794QuercetinQuercetin results in increased expression of SLC19A3 mRNA21632981
C017947sodium arsenitesodium arsenite affects the methylation of SLC19A3 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of SLC19A3 mRNA22714537
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of SLC19A3 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC19A3 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SLC19A3 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of SLC19A3 mRNA24935251
D014520UrethaneUrethane results in decreased expression of SLC19A3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC19A3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC19A3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC19A3 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC19A3 gene25560391
D013831ThiamineSLC19A3 protein results in increased uptake of Thiamine16705148
D013831ThiamineThiamine deficiency results in increased expression of SLC19A3 mRNA16705148
D013831ThiamineThiamine deficiency results in increased expression of SLC19A3 protein16705148
D013831Thiamine[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 protein] which results in decreased uptake of Thiamine24244374
D013831ThiamineSLC19A3 protein results in increased uptake of Thiamine24244374
D024483Vitamin K 3Vitamin K 3 affects the expression of SLC19A3 mRNA20044591
C111237vorinostatvorinostat results in increased expression of SLC19A3 mRNA27188386
D015215ZidovudineZidovudine results in decreased expression of SLC19A3 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015234thiamine transmembrane transporter activity-ISS-  
GO:0015234thiamine transmembrane transporter activity-TAS-  
GO:0022857transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0015888thiamine transport-IEA-  
GO:0042723thiamine-containing compound metabolic process-TAS-  
GO:0055085transmembrane transport-IBA21873635  
GO:0071934thiamine transmembrane transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-NAS11136550  
KEGG ID KEGG Term
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196819Vitamin B1 (thiamin) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21921471[Familial Wernicke's-like encephalopathy]. (2010 Nov)Miyajima HRinsho Shinkeigaku
22103680Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. (2011 Nov 21)Wernimont SMBMC Med Genet
24667528Evidence for genetic susceptibility to the alcohol dependence syndrome from the thiamine transporter 2 gene solute carrier SLC19A3. (2014 Jun)Quadri GPsychiatr Genet