Gene: SRCIN1

80725
P140|SNIP
SRC kinase signaling inhibitor 1
protein-coding
17q12
Ensembl:ENSG00000277363 MIM:610786 Vega:OTTHUMG00000188493 UniprotKB:Q9C0H9
NC_000017.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.560e-1 (AD)  3.571e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAZ0.896
AATK0.891
NACAD0.882
ADORA10.881
ARHGEF20.878
EML20.875
INF20.875
ROGDI0.872
EVI5L0.866
RAB11FIP40.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.524
OR4F5-0.516
GJB2-0.482
TNFRSF11B-0.471
EGFLAM-0.465
ALAS2-0.464
RGS22-0.464
RNF135-0.451
FCGR3B-0.443
LYN-0.442

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SRCIN1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SRCIN1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SRCIN1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SRCIN1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SRCIN1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SRCIN1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of SRCIN1 mRNA25929836
C013418bromfenacoumbromfenacoum results in decreased expression of SRCIN1 protein28903499
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SRCIN1 mRNA12734012
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRCIN1 gene20938992
C031180chrysenechrysene results in increased expression of SRCIN1 mRNA26377693
D003042CocainePRMT6 protein inhibits the reaction [Cocaine results in increased expression of SRCIN1 protein]27506785
D003042CocaineCocaine results in increased expression of SRCIN1 mRNA27506785
D003042CocaineCocaine results in increased expression of SRCIN1 protein27506785
C024565ethylene dichlorideethylene dichloride results in increased expression of SRCIN1 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRCIN1 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of SRCIN1 mRNA19167457
D007854LeadLead affects the expression of SRCIN1 mRNA28903495
D008094LithiumLithium results in increased expression of SRCIN1 protein18296634
C042720mercuric bromidemercuric bromide results in decreased expression of SRCIN1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRCIN1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SRCIN1 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SRCIN1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SRCIN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SRCIN1 mRNA"25554681
D009532NickelNickel results in decreased expression of SRCIN1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide affects the expression of SRCIN1 mRNA19167457
D009966OrphenadrineOrphenadrine affects the expression of SRCIN1 mRNA23665939
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SRCIN1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SRCIN1 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SRCIN1 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of SRCIN1 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SRCIN1 mRNA23806026|2589566
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SRCIN1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRCIN1 mRNA24680724|2892240
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SRCIN1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRCIN1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SRCIN1 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased methylation of SRCIN1 gene29154799
C111237vorinostatvorinostat results in decreased expression of SRCIN1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14657239  17525734  
GO:0019901protein kinase binding-IDA17525734  
GO:0019904protein domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-IEA-  
GO:0030334regulation of cell migration-IMP17525734  
GO:0034446substrate adhesion-dependent cell spreading-IMP17525734  
GO:0050709negative regulation of protein secretion-IEA-  
GO:0061001regulation of dendritic spine morphogenesis-IMP19146815  
GO:0061098positive regulation of protein tyrosine kinase activity-IDA17525734  
GO:0061099negative regulation of protein tyrosine kinase activity-IDA17525734  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19146815  
GO:0005925focal adhesionNOTIDA14657239  
GO:0014069postsynaptic density-ISS-  
GO:0015629actin cytoskeleton-IDA14657239  
GO:0030027lamellipodium-IEA-  
GO:0030175filopodium-IEA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0043025neuronal cell body-IEA-  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27506785Histone arginine methylation in cocaine action in the nucleus accumbens. (2016 Aug 23)Damez-Werno DMProc Natl Acad Sci U S A