Gene: PTP4A2

8073
HH13|HH7-2|HU-PP-1|OV-1|PRL-2|PRL2|PTP4A|PTPCAAX2|ptp-IV1a|ptp-IV1b
protein tyrosine phosphatase type IVA, member 2
protein-coding
1p35.2
Ensembl:ENSG00000184007 MIM:601584 Vega:OTTHUMG00000003801 UniprotKB:Q12974
NC_000001.11
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.427e-1 (AD)  1.539e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs646370chr1:31935565 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs591833chr1:31932289 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs639233chr1:31907280 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs682654chr1:31905922 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZEB20.931
ANKRD400.927
GAB20.923
NSRP10.922
MAP40.921
SNX60.917
MBP0.916
ANP32B0.915
SEPT40.914
PLA2G160.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.567
OR4F5-0.482
CUX2-0.379
CHRNA2-0.341
LTK-0.333
PCDH8-0.332
SP8-0.332
CDH22-0.32
HCN4-0.319
KCNQ4-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PTP4A2 mRNA16788091
D020106AcrylamideAcrylamide results in decreased expression of PTP4A2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PTP4A2 gene27153756
D001280AtrazineAtrazine results in increased expression of PTP4A2 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTP4A2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTP4A2 mRNA20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTP4A2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTP4A2 mRNA"20018196
C044887beta-methylcholinebeta-methylcholine affects the expression of PTP4A2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of PTP4A2 mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of PTP4A2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PTP4A2 mRNA15336504
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTP4A2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of PTP4A2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PTP4A2 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of PTP4A2 mRNA20106945
D002945CisplatinCisplatin affects the reaction [Piroxicam results in decreased expression of PTP4A2 mRNA]21858171
D004041Dietary FatsDietary Fats results in increased expression of PTP4A2 mRNA19030233
D004317DoxorubicinDoxorubicin results in decreased expression of PTP4A2 mRNA19277126
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PTP4A2 mRNA23649840
D018120FinasterideFinasteride results in increased expression of PTP4A2 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PTP4A2 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PTP4A2 mRNA22634610
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PTP4A2 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PTP4A2 mRNA21179406
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PTP4A2 mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTP4A2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTP4A2 mRNA"25554681
D010578PetroleumPetroleum results in decreased expression of PTP4A2 mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of PTP4A2 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of PTP4A2 mRNA18301758
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in decreased expression of PTP4A2 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of PTP4A2 mRNA21858171
D011748PyrogallolPyrogallol results in increased expression of PTP4A2 mRNA20362636
D013467SulindacSulindac results in increased expression of PTP4A2 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTP4A2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PTP4A2 mRNA25975270
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTP4A2 gene25560391
C025643vinclozolinvinclozolin affects the expression of PTP4A2 mRNA19015723
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PTP4A2 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IBA21873635  
GO:0004727prenylated protein tyrosine phosphatase activity-TAS9514946  
GO:0005515protein binding-IPI17353931  28330616  
GO ID GO Term Qualifier Evidence PubMed
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10940933  
GO:0005769early endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8873719RAB geranylgeranylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal