Gene: THSD7B

80731
-
thrombospondin type 1 domain containing 7B
protein-coding
2q22.1
Ensembl:ENSG00000144229 Vega:OTTHUMG00000153590 UniprotKB:Q9C0I4
NC_000002.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.250e-3 (AD)  4.729e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2375511chr2:137491882 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1869324chr2:137469872 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F20.652
NPNT0.624
PDGFD0.616
PTGFR0.597
NDNF0.595
GCNT20.585
SRL0.571
GPC30.571
EGFL60.563
NPR30.562

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGFALS-0.341
KIF19-0.337
SEPT12-0.331
HPN-0.322
DRD4-0.317
DAPK2-0.311
IL1RL1-0.301
TMPRSS5-0.297
ZAR1L-0.297
OVOL1-0.289

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of THSD7B mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of THSD7B mRNA17562736
D001151ArsenicArsenic affects the methylation of THSD7B gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of THSD7B mRNA26705709
D001280AtrazineAtrazine affects the expression of THSD7B mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of THSD7B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of THSD7B gene28505145
D002220CarbamazepineCarbamazepine affects the expression of THSD7B mRNA25979313
D003471CuprizoneCuprizone results in decreased expression of THSD7B mRNA26577399
D012999SomanSoman results in decreased expression of THSD7B mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of THSD7B mRNA19465110
D014212TretinoinTretinoin results in increased expression of THSD7B mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of THSD7B mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of THSD7B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of THSD7B mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of THSD7B gene25560391
D019287Zinc SulfateZinc Sulfate results in decreased expression of THSD7B mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. (2011 Nov)Wang KSJ Psychiatr Res
23144319Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (2013 Feb)Lee YCarcinogenesis