Gene info: ID 8074

Gene: FGF23

GENE ID: 8074

Synonyms: ADHR|FGFN|HPDR2|HYPF|PHPTC

Description: fibroblast growth factor 23

Gene type: protein-coding

Location: 12p13.32

dbXrefs: Ensembl:ENSG00000118972 MIM:605380 Vega:OTTHUMG00000168241 UniprotKB:Q9GZV9

RefSeq: NG_007087.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 12

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.172e-1 (AD) 3.875e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg23219570	chr12:4488893	FGF23		6.300e-15	Smoking	27651444
cg07178945	chr12:4488800	FGF23		1.000e-13	Smoking	27651444
cg02375409	chr12:4488749	FGF23		1.200e-10	Smoking	27651444
cg14119236	chr12:4489075	FGF23		1.200e-9	Smoking	27651444
cg07178945	chr12:4488800	FGF23		5.950e-8	Tobacco smoking	28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GPR87	0.502
MUC17	0.5
CDCA2	0.475
BNC1	0.474
TMPPE	0.467
ERVW-1	0.464
B3GNT6	0.463
IL20	0.457
ZIM3	0.456
KRT9	0.455

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
REG1A	-0.211
CLPS	-0.205
CTRB2	-0.202
PADI4	-0.2
CTRB1	-0.197
CPA1	-0.193
CELA3A	-0.191
PRSS1	-0.19
CPB1	-0.187
PNLIPRP2	-0.186

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C097949	1,25-dihydroxyvitamin D	"FGF23 protein affects the metabolism of and affects the abundance of 1,25-dihydroxyvitamin D"	14966565
C097949	1,25-dihydroxyvitamin D	"FGF23 protein results in decreased abundance of 1,25-dihydroxyvitamin D"	15040831
C097949	1,25-dihydroxyvitamin D	"FGF23 protein results in decreased abundance of 1,25-dihydroxyvitamin D"	15040831
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]	17699549
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]	16144964
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]	17699549
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]	17699549
D000082	Acetaminophen	Acetaminophen affects the expression of FGF23 mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FGF23 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in decreased expression of FGF23 mRNA"	22863853
D001151	Arsenic	Arsenic affects the expression of FGF23 protein	24675094
D001280	Atrazine	Atrazine results in increased expression of FGF23 mRNA	25929836
C031463	beta-glycerophosphoric acid	beta-glycerophosphoric acid results in increased expression of FGF23 mRNA	15542045
C006780	bisphenol A	bisphenol A results in decreased expression of FGF23 mRNA	25181051
D002101	Cacodylic Acid	Cacodylic Acid results in decreased expression of FGF23 mRNA	17441966
D002104	Cadmium	[Cadmium results in increased expression of GALNT3 protein] which results in decreased metabolism of and results in increased secretion of FGF23 protein	24614234
D002104	Cadmium	Cadmium results in increased secretion of FGF23 protein	24614234
D002118	Calcium	Calcium affects the expression of FGF23 mRNA	16381997
D002118	Calcium	Calcium affects the expression of FGF23 protein	15086938
C031556	calcium bicarbonate	[Sevelamer co-treated with calcium bicarbonate] results in decreased expression of FGF23 protein	16076378
D002136	Calcium, Dietary	"Calcium, Dietary results in increased expression of FGF23 mRNA"	15998839
D002136	Calcium, Dietary	"Calcium, Dietary results in increased expression of FGF23 protein"	15998839
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of FGF23 mRNA	18502319
D002809	Chondroitin Sulfates	Chondroitin Sulfates analog results in increased activity of FGF23 protein	16081635
D003300	Copper	Copper deficiency results in increased expression of FGF23 mRNA	26033743
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of FGF23 mRNA	24317228
D003871	Dermatan Sulfate	Dermatan Sulfate analog results in increased activity of FGF23 protein	16081635
D003976	Diazinon	Diazinon results in decreased expression of FGF23 mRNA	19130878
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of FGF23 mRNA	26924002
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of FGF23 mRNA	26033743
D002117	Calcitriol	Calcitriol results in increased expression of FGF23 protein	15956805\|1623496
D002117	Calcitriol	FGF23 protein affects the susceptibility to Calcitriol	15698453
D002117	Calcitriol	FGF23 protein results in decreased abundance of Calcitriol	15264182\|1591733
D002117	Calcitriol	[Calcitriol co-treated with Phosphates] results in increased expression of FGF23 mRNA	15671080
D002117	Calcitriol	Calcitriol results in increased expression of FGF23 mRNA	16020653
D002117	Calcitriol	Calcitriol results in increased expression of FGF23 protein	16020653
D002117	Calcitriol	PHEX protein inhibits the reaction [FGF23 protein results in decreased abundance of Calcitriol]	16449303
D002117	Calcitriol	Calcitriol results in increased expression of FGF23 mRNA	16020653
D002117	Calcitriol	Calcitriol results in increased expression of FGF23 mRNA	17293108
D002117	Calcitriol	Calcitriol results in increased expression of FGF23 protein	15531762
D002117	Calcitriol	FGF23 protein results in decreased abundance of Calcitriol	16020653
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of FGF23 mRNA	26924002
C532254	GSK 650394	GSK 650394 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D006493	Heparin	Heparin promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
D006493	Heparin	Heparin analog results in increased activity of FGF23 protein	16081635
D006493	Heparin	Heparin promotes the reaction [FGF23 protein mutant form results in decreased transport of Phosphates]	16105045
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in increased activity of FGF23 protein	16081635
C029424	hydrazine	hydrazine results in decreased expression of FGF23 mRNA	15282401
D002112	Calcifediol	Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]	26851681
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA	16415329
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of FGF23 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of FGF23 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FGF23 mRNA"	25554681
C019248	pamidronate	pamidronate results in decreased expression of FGF23 protein	15838626
C506614	PD 0325901	PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]	23872713
C506614	PD 0325901	PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]	23872713
C506614	PD 0325901	PD 0325901 results in increased expression of and results in increased secretion of FGF23 protein	23872713
D015232	Dinoprostone	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]	16144964
D015232	Dinoprostone	FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone	16144964
D015232	Dinoprostone	SB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]	16144964
D010710	Phosphates	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
D010710	Phosphates	Heparin promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
D010710	Phosphates	SB 203580 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
D010710	Phosphates	SU 5402 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
D010710	Phosphates	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	FGF23 protein affects the abundance of and affects the metabolism of Phosphates	16369891
D010710	Phosphates	FGF23 protein affects the abundance of Phosphates	14988389\|1561342
D010710	Phosphates	FGF23 protein affects the metabolism of Phosphates	15284207\|1596155
D010710	Phosphates	FGF23 protein affects the transport of and affects the abundance of Phosphates	15995295
D010710	Phosphates	FGF23 protein mutant form results in decreased uptake of Phosphates	11409890
D010710	Phosphates	FGF23 protein results in decreased uptake of Phosphates	11409890\|2743288
D010710	Phosphates	FGFR1 protein alternative form promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	GSK 650394 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	KL protein affects the reaction [FGF23 protein affects the abundance of Phosphates]	17710231
D010710	Phosphates	KL protein promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	Phosphates affects the expression of FGF23 protein	15086938
D010710	Phosphates	Phosphates results in increased expression of FGF23 mRNA	15542045
D010710	Phosphates	Phosphates results in increased expression of FGF23 protein	18256372
D010710	Phosphates	SLC9A3R1 protein promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	sodium chlorate inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010710	Phosphates	[Calcitriol co-treated with Phosphates] results in increased expression of FGF23 mRNA	15671080
D010710	Phosphates	FGF23 protein affects the abundance of Phosphates	15995295\|1601146
D010710	Phosphates	FGF23 protein affects the metabolism of and affects the abundance of Phosphates	14966565
D010710	Phosphates	FGF23 protein results in decreased abundance of Phosphates	15040831
D010710	Phosphates	FGF23 protein results in decreased transport of Phosphates	15885032
D010710	Phosphates	FGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]	16076377
D010710	Phosphates	PHEX protein inhibits the reaction [FGF23 protein results in decreased abundance of Phosphates]	16449303
D010710	Phosphates	VDR protein affects the reaction [FGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]]	16076377
D010710	Phosphates	FGF23 protein affects the abundance of Phosphates	12851820
D010710	Phosphates	FGF23 protein affects the abundance of Phosphates	11956156
D010710	Phosphates	FGF23 protein affects the metabolism of and affects the abundance of Phosphates	16081635
D010710	Phosphates	FGF23 protein affects the transport of Phosphates	16214071
D010710	Phosphates	Heparin promotes the reaction [FGF23 protein mutant form results in decreased transport of Phosphates]	16105045
D010758	Phosphorus	FGF23 protein affects the abundance of Phosphorus	15356053
D010758	Phosphorus	FGF23 protein mutant form affects the transport of and affects the abundance of Phosphorus	12419819
D010758	Phosphorus	Phosphorus results in increased expression of FGF23 protein	15356053
D010758	Phosphorus	FGF23 protein results in decreased abundance of Phosphorus	17699549
D010758	Phosphorus	FGF23 protein results in decreased transport of Phosphorus	17699549
D010758	Phosphorus	Phosphorus affects the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]	17699549
D010758	Phosphorus	Phosphorus affects the reaction [FGF23 protein results in increased expression of CYP24A1 mRNA]	17699549
D010758	Phosphorus	FGF23 protein affects the metabolism of Phosphorus	16123154
D016226	Phosphorus, Dietary	"Phosphorus, Dietary results in increased expression of FGF23 protein"	15613425
D016226	Phosphorus, Dietary	"PHEX protein affects the reaction [Phosphorus, Dietary results in increased expression of FGF23 protein]"	16123154
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of FGF23 protein"	15869926
D016226	Phosphorus, Dietary	"Phosphorus, Dietary results in increased expression of FGF23 mRNA"	16123154
D016226	Phosphorus, Dietary	"Phosphorus, Dietary results in increased expression of FGF23 protein"	15998839\|1612315
D016226	Phosphorus, Dietary	"SLC34A1 protein affects the reaction [Phosphorus, Dietary results in increased expression of FGF23 protein]"	16123154
D016226	Phosphorus, Dietary	"Phosphorus, Dietary results in increased expression of FGF23 protein"	15531762
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of FGF23 mRNA	27845199
D010936	Plant Extracts	Plant Extracts results in decreased expression of FGF23 mRNA	23557933
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors results in increased expression of FGF23 protein	21976371
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA	16415329
C093642	SB 203580	SB 203580 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
C093642	SB 203580	SB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]	16144964
D000069603	Sevelamer	[Sevelamer co-treated with calcium bicarbonate] results in decreased expression of FGF23 protein	16076378
D000069603	Sevelamer	Sevelamer results in decreased expression of FGF23 protein	16272627
D012964	Sodium	FGF23 protein results in decreased transport of Sodium	17699549
D012964	Sodium	FGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]	16076377
D012964	Sodium	VDR protein affects the reaction [FGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]]	16076377
C032706	sodium chlorate	sodium chlorate inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D053260	Soot	Soot results in increased expression of FGF23 mRNA	26551751
C105686	SU 5402	SU 5402 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]	12032146
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FGF23 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FGF23	19367694
D013806	Theophylline	Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]	26851681
D013806	Theophylline	Theophylline results in increased expression of FGF23 protein	26851681
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of FGF23 gene	26756918
D014635	Valproic Acid	Valproic Acid affects the expression of FGF23 mRNA	17292431
D000225	Adenine	Adenine results in increased expression of FGF23 protein	16272627
D014807	Vitamin D	FGF23 protein affects the metabolism of Vitamin D	15284207\|1583862
D014807	Vitamin D	FGF23 protein results in increased metabolism of Vitamin D	15956805
D014807	Vitamin D	KL protein affects the reaction [FGF23 protein affects the abundance of Vitamin D]	17710231
D014807	Vitamin D	FGF23 protein affects the metabolism of and affects the abundance of Vitamin D	16081635
D014807	Vitamin D	FGF23 protein affects the metabolism of Vitamin D	16123154

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005105	type 1 fibroblast growth factor receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	17086194 19966287
GO:0008083	growth factor activity	-	IEA	-
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010966	regulation of phosphate transport	-	IDA	11409890
GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	-	IDA	15040831
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0030154	cell differentiation	-	IEA	-
GO:0030502	negative regulation of bone mineralization	-	IDA	18282132
GO:0030643	cellular phosphate ion homeostasis	-	IEA	-
GO:0032026	response to magnesium ion	-	IEA	-
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0042369	vitamin D catabolic process	-	IDA	15040831
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0044320	cellular response to leptin stimulus	-	IEA	-
GO:0045668	negative regulation of osteoblast differentiation	-	IDA	18282132
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0046888	negative regulation of hormone secretion	-	ISS	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0055062	phosphate ion homeostasis	-	IMP	11062477
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0071305	cellular response to vitamin D	-	IEA	-
GO:0071354	cellular response to interleukin-6	-	IEA	-
GO:0071374	cellular response to parathyroid hormone stimulus	-	IEA	-
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	-	IEA	-
GO:1904383	response to sodium phosphate	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	16638743
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005796	Golgi lumen	-	TAS	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05218	Melanoma

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1226099	Signaling by FGFR in disease	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1839122	Signaling by activated point mutants of FGFR1	TAS
R-HSA-1839124	FGFR1 mutant receptor activation	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	TAS
R-HSA-1839130	Signaling by activated point mutants of FGFR3	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190239	FGFR3 ligand binding and activation	TAS
R-HSA-190241	FGFR2 ligand binding and activation	TAS
R-HSA-190242	FGFR1 ligand binding and activation	TAS
R-HSA-190322	FGFR4 ligand binding and activation	TAS
R-HSA-190372	FGFR3c ligand binding and activation	TAS
R-HSA-190373	FGFR1c ligand binding and activation	TAS
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	TAS
R-HSA-190375	FGFR2c ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2033514	FGFR3 mutant receptor activation	TAS
R-HSA-2033519	Activated point mutants of FGFR2	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	TAS
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	TAS
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	TAS
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654695	PI-3K cascade:FGFR2	TAS
R-HSA-5654696	Downstream signaling of activated FGFR2	TAS
R-HSA-5654699	SHC-mediated cascade:FGFR2	TAS
R-HSA-5654700	FRS-mediated FGFR2 signaling	TAS
R-HSA-5654704	SHC-mediated cascade:FGFR3	TAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	TAS
R-HSA-5654708	Downstream signaling of activated FGFR3	TAS
R-HSA-5654710	PI-3K cascade:FGFR3	TAS
R-HSA-5654712	FRS-mediated FGFR4 signaling	TAS
R-HSA-5654716	Downstream signaling of activated FGFR4	TAS
R-HSA-5654719	SHC-mediated cascade:FGFR4	TAS
R-HSA-5654720	PI-3K cascade:FGFR4	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	TAS
R-HSA-5655302	Signaling by FGFR1 in disease	TAS
R-HSA-5655332	Signaling by FGFR3 in disease	TAS
R-HSA-5658623	FGFRL1 modulation of FGFR1 signaling	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24683472	Cardiovascular risk markers associated with arterial calcification in patients with chronic kidney disease Stages 3 and 4. (2014 Apr)	Kiu Weber CI	Clin Kidney J
28651327	Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics. (2017 Sep 1)	Quintero-Platt G	Alcohol Alcohol
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