Gene: FGF23

8074
ADHR|FGFN|HPDR2|HYPF|PHPTC
fibroblast growth factor 23
protein-coding
12p13.32
Ensembl:ENSG00000118972 MIM:605380 Vega:OTTHUMG00000168241 UniprotKB:Q9GZV9
NG_007087.1
PubMed
ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.172e-1 (AD)  3.875e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23219570chr12:4488893FGF236.300e-15Smoking27651444
cg07178945chr12:4488800FGF231.000e-13Smoking27651444
cg02375409chr12:4488749FGF231.200e-10Smoking27651444
cg14119236chr12:4489075FGF231.200e-9Smoking27651444
cg07178945chr12:4488800FGF235.950e-8Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR870.502
MUC170.5
CDCA20.475
BNC10.474
TMPPE0.467
ERVW-10.464
B3GNT60.463
IL200.457
ZIM30.456
KRT90.455

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REG1A-0.211
CLPS-0.205
CTRB2-0.202
PADI4-0.2
CTRB1-0.197
CPA1-0.193
CELA3A-0.191
PRSS1-0.19
CPB1-0.187
PNLIPRP2-0.186

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"FGF23 protein affects the metabolism of and affects the abundance of 1,25-dihydroxyvitamin D"14966565
C0979491,25-dihydroxyvitamin D"FGF23 protein results in decreased abundance of 1,25-dihydroxyvitamin D"15040831
C0979491,25-dihydroxyvitamin D"FGF23 protein results in decreased abundance of 1,25-dihydroxyvitamin D"15040831
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]17699549
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]16144964
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]17699549
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]17699549
D000082AcetaminophenAcetaminophen affects the expression of FGF23 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF23 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of FGF23 mRNA"22863853
D001151ArsenicArsenic affects the expression of FGF23 protein24675094
D001280AtrazineAtrazine results in increased expression of FGF23 mRNA25929836
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in increased expression of FGF23 mRNA15542045
C006780bisphenol Abisphenol A results in decreased expression of FGF23 mRNA25181051
D002101Cacodylic AcidCacodylic Acid results in decreased expression of FGF23 mRNA17441966
D002104Cadmium[Cadmium results in increased expression of GALNT3 protein] which results in decreased metabolism of and results in increased secretion of FGF23 protein24614234
D002104CadmiumCadmium results in increased secretion of FGF23 protein24614234
D002118CalciumCalcium affects the expression of FGF23 mRNA16381997
D002118CalciumCalcium affects the expression of FGF23 protein15086938
C031556calcium bicarbonate[Sevelamer co-treated with calcium bicarbonate] results in decreased expression of FGF23 protein16076378
D002136Calcium, Dietary"Calcium, Dietary results in increased expression of FGF23 mRNA"15998839
D002136Calcium, Dietary"Calcium, Dietary results in increased expression of FGF23 protein"15998839
D004390ChlorpyrifosChlorpyrifos affects the expression of FGF23 mRNA18502319
D002809Chondroitin SulfatesChondroitin Sulfates analog results in increased activity of FGF23 protein16081635
D003300CopperCopper deficiency results in increased expression of FGF23 mRNA26033743
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FGF23 mRNA24317228
D003871Dermatan SulfateDermatan Sulfate analog results in increased activity of FGF23 protein16081635
D003976DiazinonDiazinon results in decreased expression of FGF23 mRNA19130878
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of FGF23 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of FGF23 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of FGF23 protein15956805|1623496
D002117CalcitriolFGF23 protein affects the susceptibility to Calcitriol15698453
D002117CalcitriolFGF23 protein results in decreased abundance of Calcitriol15264182|1591733
D002117Calcitriol[Calcitriol co-treated with Phosphates] results in increased expression of FGF23 mRNA15671080
D002117CalcitriolCalcitriol results in increased expression of FGF23 mRNA16020653
D002117CalcitriolCalcitriol results in increased expression of FGF23 protein16020653
D002117CalcitriolPHEX protein inhibits the reaction [FGF23 protein results in decreased abundance of Calcitriol]16449303
D002117CalcitriolCalcitriol results in increased expression of FGF23 mRNA16020653
D002117CalcitriolCalcitriol results in increased expression of FGF23 mRNA17293108
D002117CalcitriolCalcitriol results in increased expression of FGF23 protein15531762
D002117CalcitriolFGF23 protein results in decreased abundance of Calcitriol16020653
C024629dimethyl phthalatedimethyl phthalate results in increased expression of FGF23 mRNA26924002
C532254GSK 650394GSK 650394 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D006493HeparinHeparin promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
D006493HeparinHeparin analog results in increased activity of FGF23 protein16081635
D006493HeparinHeparin promotes the reaction [FGF23 protein mutant form results in decreased transport of Phosphates]16105045
D006820Hyaluronic AcidHyaluronic Acid analog results in increased activity of FGF23 protein16081635
C029424hydrazinehydrazine results in decreased expression of FGF23 mRNA15282401
D002112CalcifediolCalcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]26851681
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA16415329
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of FGF23 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of FGF23 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FGF23 mRNA"25554681
C019248pamidronatepamidronate results in decreased expression of FGF23 protein15838626
C506614PD 0325901PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK1 protein]23872713
C506614PD 0325901PD 0325901 inhibits the reaction [FGF23 protein results in increased phosphorylation of MAPK3 protein]23872713
C506614PD 0325901PD 0325901 results in increased expression of and results in increased secretion of FGF23 protein23872713
D015232Dinoprostone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]16144964
D015232DinoprostoneFGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone16144964
D015232DinoprostoneSB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]16144964
D010710Phosphates2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
D010710PhosphatesHeparin promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
D010710PhosphatesSB 203580 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
D010710PhosphatesSU 5402 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
D010710Phosphates2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D010710PhosphatesFGF23 protein affects the abundance of and affects the metabolism of Phosphates16369891
D010710PhosphatesFGF23 protein affects the abundance of Phosphates14988389|1561342
D010710PhosphatesFGF23 protein affects the metabolism of Phosphates15284207|1596155
D010710PhosphatesFGF23 protein affects the transport of and affects the abundance of Phosphates15995295
D010710PhosphatesFGF23 protein mutant form results in decreased uptake of Phosphates11409890
D010710PhosphatesFGF23 protein results in decreased uptake of Phosphates11409890|2743288
D010710PhosphatesFGFR1 protein alternative form promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D010710PhosphatesGSK 650394 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D010710PhosphatesKL protein affects the reaction [FGF23 protein affects the abundance of Phosphates]17710231
D010710PhosphatesKL protein promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D010710PhosphatesPhosphates affects the expression of FGF23 protein15086938
D010710PhosphatesPhosphates results in increased expression of FGF23 mRNA15542045
D010710PhosphatesPhosphates results in increased expression of FGF23 protein18256372
D010710PhosphatesSLC9A3R1 protein promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D010710Phosphatessodium chlorate inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D010710Phosphates[Calcitriol co-treated with Phosphates] results in increased expression of FGF23 mRNA15671080
D010710PhosphatesFGF23 protein affects the abundance of Phosphates15995295|1601146
D010710PhosphatesFGF23 protein affects the metabolism of and affects the abundance of Phosphates14966565
D010710PhosphatesFGF23 protein results in decreased abundance of Phosphates15040831
D010710PhosphatesFGF23 protein results in decreased transport of Phosphates15885032
D010710PhosphatesFGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]16076377
D010710PhosphatesPHEX protein inhibits the reaction [FGF23 protein results in decreased abundance of Phosphates]16449303
D010710PhosphatesVDR protein affects the reaction [FGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]]16076377
D010710PhosphatesFGF23 protein affects the abundance of Phosphates12851820
D010710PhosphatesFGF23 protein affects the abundance of Phosphates11956156
D010710PhosphatesFGF23 protein affects the metabolism of and affects the abundance of Phosphates16081635
D010710PhosphatesFGF23 protein affects the transport of Phosphates16214071
D010710PhosphatesHeparin promotes the reaction [FGF23 protein mutant form results in decreased transport of Phosphates]16105045
D010758PhosphorusFGF23 protein affects the abundance of Phosphorus15356053
D010758PhosphorusFGF23 protein mutant form affects the transport of and affects the abundance of Phosphorus12419819
D010758PhosphorusPhosphorus results in increased expression of FGF23 protein15356053
D010758PhosphorusFGF23 protein results in decreased abundance of Phosphorus17699549
D010758PhosphorusFGF23 protein results in decreased transport of Phosphorus17699549
D010758PhosphorusPhosphorus affects the reaction [FGF23 protein results in decreased expression of CYP27B1 mRNA]17699549
D010758PhosphorusPhosphorus affects the reaction [FGF23 protein results in increased expression of CYP24A1 mRNA]17699549
D010758PhosphorusFGF23 protein affects the metabolism of Phosphorus16123154
D016226Phosphorus, Dietary"Phosphorus, Dietary results in increased expression of FGF23 protein"15613425
D016226Phosphorus, Dietary"PHEX protein affects the reaction [Phosphorus, Dietary results in increased expression of FGF23 protein]"16123154
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of FGF23 protein"15869926
D016226Phosphorus, Dietary"Phosphorus, Dietary results in increased expression of FGF23 mRNA"16123154
D016226Phosphorus, Dietary"Phosphorus, Dietary results in increased expression of FGF23 protein"15998839|1612315
D016226Phosphorus, Dietary"SLC34A1 protein affects the reaction [Phosphorus, Dietary results in increased expression of FGF23 protein]"16123154
D016226Phosphorus, Dietary"Phosphorus, Dietary results in increased expression of FGF23 protein"15531762
C014153pirimiphos methylpirimiphos methyl results in decreased expression of FGF23 mRNA27845199
D010936Plant ExtractsPlant Extracts results in decreased expression of FGF23 mRNA23557933
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in increased expression of FGF23 protein21976371
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA16415329
C093642SB 203580SB 203580 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
C093642SB 203580SB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]16144964
D000069603Sevelamer[Sevelamer co-treated with calcium bicarbonate] results in decreased expression of FGF23 protein16076378
D000069603SevelamerSevelamer results in decreased expression of FGF23 protein16272627
D012964SodiumFGF23 protein results in decreased transport of Sodium17699549
D012964SodiumFGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]16076377
D012964SodiumVDR protein affects the reaction [FGF23 protein results in decreased transport of [Sodium co-treated with Phosphates]]16076377
C032706sodium chloratesodium chlorate inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]27432882
D053260SootSoot results in increased expression of FGF23 mRNA26551751
C105686SU 5402SU 5402 inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]12032146
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FGF23 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FGF2319367694
D013806TheophyllineCalcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein]26851681
D013806TheophyllineTheophylline results in increased expression of FGF23 protein26851681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of FGF23 gene26756918
D014635Valproic AcidValproic Acid affects the expression of FGF23 mRNA17292431
D000225AdenineAdenine results in increased expression of FGF23 protein16272627
D014807Vitamin DFGF23 protein affects the metabolism of Vitamin D15284207|1583862
D014807Vitamin DFGF23 protein results in increased metabolism of Vitamin D15956805
D014807Vitamin DKL protein affects the reaction [FGF23 protein affects the abundance of Vitamin D]17710231
D014807Vitamin DFGF23 protein affects the metabolism of and affects the abundance of Vitamin D16081635
D014807Vitamin DFGF23 protein affects the metabolism of Vitamin D16123154

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005105type 1 fibroblast growth factor receptor binding-IEA-  
GO:0005515protein binding-IPI17086194  19966287  
GO:0008083growth factor activity-IEA-  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0008543fibroblast growth factor receptor signaling pathway-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010966regulation of phosphate transport-IDA11409890  
GO:0010980positive regulation of vitamin D 24-hydroxylase activity-IDA15040831  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030502negative regulation of bone mineralization-IDA18282132  
GO:0030643cellular phosphate ion homeostasis-IEA-  
GO:0032026response to magnesium ion-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0042369vitamin D catabolic process-IDA15040831  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0044320cellular response to leptin stimulus-IEA-  
GO:0045668negative regulation of osteoblast differentiation-IDA18282132  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0046888negative regulation of hormone secretion-ISS-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0055062phosphate ion homeostasis-IMP11062477  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071305cellular response to vitamin D-IEA-  
GO:0071354cellular response to interleukin-6-IEA-  
GO:0071374cellular response to parathyroid hormone stimulus-IEA-  
GO:0090080positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway-IEA-  
GO:1904383response to sodium phosphate-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA16638743  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1839122Signaling by activated point mutants of FGFR1TAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-1839126FGFR2 mutant receptor activationTAS
R-HSA-1839130Signaling by activated point mutants of FGFR3TAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-190239FGFR3 ligand binding and activationTAS
R-HSA-190241FGFR2 ligand binding and activationTAS
R-HSA-190242FGFR1 ligand binding and activationTAS
R-HSA-190322FGFR4 ligand binding and activationTAS
R-HSA-190372FGFR3c ligand binding and activationTAS
R-HSA-190373FGFR1c ligand binding and activationTAS
R-HSA-190374FGFR1c and Klotho ligand binding and activationTAS
R-HSA-190375FGFR2c ligand binding and activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2033514FGFR3 mutant receptor activationTAS
R-HSA-2033519Activated point mutants of FGFR2TAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5654219Phospholipase C-mediated cascade: FGFR1TAS
R-HSA-5654221Phospholipase C-mediated cascade; FGFR2TAS
R-HSA-5654227Phospholipase C-mediated cascade; FGFR3TAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654688SHC-mediated cascade:FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654693FRS-mediated FGFR1 signalingTAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654699SHC-mediated cascade:FGFR2TAS
R-HSA-5654700FRS-mediated FGFR2 signalingTAS
R-HSA-5654704SHC-mediated cascade:FGFR3TAS
R-HSA-5654706FRS-mediated FGFR3 signalingTAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654710PI-3K cascade:FGFR3TAS
R-HSA-5654712FRS-mediated FGFR4 signalingTAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654719SHC-mediated cascade:FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654726Negative regulation of FGFR1 signalingTAS
R-HSA-5654727Negative regulation of FGFR2 signalingTAS
R-HSA-5654732Negative regulation of FGFR3 signalingTAS
R-HSA-5654733Negative regulation of FGFR4 signalingTAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5658623FGFRL1 modulation of FGFR1 signalingTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24683472Cardiovascular risk markers associated with arterial calcification in patients with chronic kidney disease Stages 3 and 4. (2014 Apr)Kiu Weber CIClin Kidney J
28651327Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics. (2017 Sep 1)Quintero-Platt GAlcohol Alcohol
18167138Primary hyperparathyroidism and the skeleton. (2008 Jul)Mosekilde LClin Endocrinol (Oxf)
21873490Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women. (2011 Nov)Dalal MEur J Endocrinol
22530966Fibroblast growth factor 23 is associated with proteinuria and smoking in chronic kidney disease: an analysis of the MASTERPLAN cohort. (2012 Apr 24)Vervloet MGBMC Nephrol
23339433Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study. (2013 Jan 22)Nakayama MBMC Nephrol
21570529Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease. (2011 May)Taylor ENAm Heart J
28191535Association of serum intact fibroblast growth factor 23 with left ventricular mass and different echocardiographic findings in patients on hemodialysis. (2016 Sep 1)Nassiri AAJ Transl Int Med
29336609Fibroblast growth factor 23 (FGF23) gene polymorphisms are associated with essential hypertension risk and blood pressure levels in Chinese Han population. (2018 Jan 16)Cai PClin Exp Hypertens
26307135Fibroblast growth factor 23: associations with antiretroviral therapy in patients co-infected with HIV and hepatitis C. (2016 May)Young JHIV Med
18974917Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men. (2009 Jul)Marsell ROsteoporos Int
27385427Plasma Fibroblast Growth Factor 23: Clinical Correlates and Association With Cardiovascular Disease and Mortality in the Framingham Heart Study. (2016 Jul 6)Haring RJ Am Heart Assoc