Gene: MFAP5

8076
AAT9|MAGP-2|MAGP2|MFAP-5|MP25
microfibril associated protein 5
protein-coding
12p13.31
Ensembl:ENSG00000197614 MIM:601103 Vega:OTTHUMG00000168703 UniprotKB:Q13361
NG_041814.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.611e-2 (AD)  8.814e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10505737chr12:8651976 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRDN0.606
PDLIM50.594
XIRP20.587
LPP0.585
AMPD10.572
GNG120.571
PARD3B0.57
MSI20.56
COMP0.559
ZFHX40.557

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIDEA-0.462
RHEBL1-0.437
IL1RL2-0.43
CORT-0.418
RHO-0.416
CALHM1-0.415
RTP1-0.414
RDH12-0.411
LYZL4-0.411
ADRA1D-0.407

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MFAP5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MFAP5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MFAP5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MFAP5 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MFAP5 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MFAP5 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MFAP5 mRNA"25351596
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MFAP5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MFAP5 mRNA22228805
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of MFAP5 mRNA17404688
D004958EstradiolEstradiol results in increased expression of MFAP5 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of MFAP5 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of MFAP5 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MFAP5 mRNA17484886
C100187chloropicrinchloropicrin results in decreased expression of MFAP5 mRNA26352163|2847649
D016572CyclosporineCyclosporine results in increased methylation of MFAP5 promoter27989131
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MFAP5 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of MFAP5 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of MFAP5 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MFAP5 mRNA24893172
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of MFAP5 mRNA20705681
D004041Dietary FatsDietary Fats results in increased expression of MFAP5 mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of MFAP5 mRNA21852083
D002117CalcitriolCalcitriol results in decreased expression of MFAP5 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MFAP5 mRNA"22485181
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of MFAP5 mRNA24834073
D004237DiuronDiuron results in decreased expression of MFAP5 mRNA21551480|2515243
C118739entinostatentinostat results in increased expression of MFAP5 mRNA27188386
C039281furanfuran results in increased expression of MFAP5 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of MFAP5 mRNA28973697
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MFAP5 mRNA16054899
D007545IsoproterenolIsoproterenol results in increased expression of MFAP5 mRNA20003209
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MFAP5 mRNA"27188386
D008628MercuryMercury results in increased expression of MFAP5 mRNA16823088
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MFAP5 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MFAP5 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MFAP5 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of MFAP5 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MFAP5 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MFAP5 mRNA25729387
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of MFAP5 mRNA20705681
D000073878Palm OilPalm Oil results in increased expression of MFAP5 mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MFAP5 mRNA22237054
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MFAP5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MFAP5 mRNA26272509
D011374ProgesteroneProgesterone results in decreased expression of MFAP5 mRNA23012394
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of MFAP5 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of MFAP5 mRNA24780913
D020849Raloxifene HydrochlorideESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MFAP5 mRNA]14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of MFAP5 mRNA14699072
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of MFAP5 mRNA21852083
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of MFAP5 mRNA16054899
D012822Silicon DioxideSilicon Dioxide results in increased expression of MFAP5 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MFAP5 mRNA22431001
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of MFAP5 mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of MFAP5 mRNA18812580
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of MFAP5 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MFAP5 mRNA21998131
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of MFAP5 mRNA]12151645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MFAP5 mRNA12151645|1221567
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MFAP5 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MFAP5 mRNA25729387
D014212TretinoinTretinoin results in increased expression of MFAP5 mRNA21934132
C032910triadimefontriadimefon results in decreased expression of MFAP5 mRNA26705709
C057693troglitazonetroglitazone results in increased expression of MFAP5 mRNA28973697
C025643vinclozolinvinclozolin affects the expression of MFAP5 mRNA19015723
D014800VitalliumVitallium analog results in increased expression of MFAP5 mRNA23825117
D019287Zinc SulfateZinc Sulfate results in decreased expression of MFAP5 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-TAS8557636  
GO ID GO Term Qualifier Evidence PubMed
GO:0030198extracellular matrix organization-TAS-  
GO:0060216definitive hemopoiesis-ISS-  
GO:0097435supramolecular fiber organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001527microfibril-ISS-  
GO:0005576extracellular region-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27068509  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566948Elastic fibre formationIEA
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-2129379Molecules associated with elastic fibresIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal