Gene: ITIH5

80760
ITI-HC5|PP14776
inter-alpha-trypsin inhibitor heavy chain family member 5
protein-coding
10p14
Ensembl:ENSG00000123243 MIM:609783 Vega:OTTHUMG00000017635 UniprotKB:Q86UX2
NG_047199.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.393e-1 (AD)  1.268e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12247601chr10:7569535 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC6A130.749
RGS50.73
ABCG20.727
SLC38A50.703
MUSTN10.698
SLC6A120.696
P2RY140.678
COBLL10.676
CCM2L0.669
NOTCH30.66

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OCSTAMP-0.375
MYBPH-0.365
APOL4-0.359
GRHL3-0.357
S100A3-0.348
TPST1-0.342
SERPINA3-0.333
BCL2L10-0.331
MARCH3-0.331
GLRX-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ITIH5 mRNA19933214
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ITIH5 mRNA"20702594
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITIH5 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ITIH5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ITIH5 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ITIH5 mRNA24449571
D001151ArsenicArsenic affects the methylation of ITIH5 gene25304211
C015001arsenitearsenite results in increased methylation of ITIH5 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of ITIH5 mRNA22323515
C487081belinostatbelinostat results in increased expression of ITIH5 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITIH5 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITIH5 mRNA19770486
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITIH5 mRNA20823114
C006780bisphenol Abisphenol A promotes the reaction [ITIH5 protein binds to ESR1 protein]27156127
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ITIH5 mRNA27339419
C100187chloropicrinchloropicrin results in increased expression of ITIH5 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITIH5 mRNA20938992
C031180chrysenechrysene results in increased expression of ITIH5 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in increased expression of ITIH5 mRNA20105288
D019327Copper SulfateCopper Sulfate results in decreased expression of ITIH5 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ITIH5 mRNA25562108|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ITIH5 mRNA24317228
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITIH5 mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ITIH5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ITIH5 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ITIH5 mRNA24535843
C118739entinostatentinostat results in increased expression of ITIH5 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
D000431EthanolEthanol results in increased expression of ITIH5 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ITIH5 mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITIH5 mRNA20938992
C039281furanfuran results in increased expression of ITIH5 mRNA24183702
D017313FenretinideFenretinide results in decreased expression of ITIH5 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ITIH5 mRNA27392435
C008261lead acetatelead acetate results in increased expression of ITIH5 mRNA21829687
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of ITIH5 mRNA20823114
C042720mercuric bromidemercuric bromide results in increased expression of ITIH5 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITIH5 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ITIH5 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITIH5 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ITIH5 promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ITIH5 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ITIH5 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of ITIH5 mRNA24768652|2558310
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of ITIH5 mRNA24888373
D010100OxygenOxygen deficiency results in increased expression of ITIH5 mRNA24205000
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ITIH5 mRNA26272509
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ITIH5 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ITIH5 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ITIH5 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ITIH5 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ITIH5 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of ITIH5 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of ITIH5 mRNA24888373
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ITIH5 mRNA27029645
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ITIH5 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ITIH5 mRNA23221170
C009277sodium arsenatesodium arsenate results in decreased expression of ITIH5 mRNA21795629
D013629TamoxifenTamoxifen affects the expression of ITIH5 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ITIH5 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITIH5 mRNA20702594|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ITIH5 mRNA19933214|2629044
C009495titanium dioxidetitanium dioxide results in decreased expression of ITIH5 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ITIH5 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITIH5 mRNA28111298
C012589trichostatin Atrichostatin A results in increased expression of ITIH5 mRNA24935251
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of ITIH5 mRNA28934090
C057693troglitazonetroglitazone results in decreased expression of ITIH5 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITIH5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ITIH5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ITIH5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of ITIH5 mRNA21427059|2489608
C029297vinylidene chloridevinylidene chloride results in decreased expression of ITIH5 mRNA26682919
C111237vorinostatvorinostat results in increased expression of ITIH5 mRNA27188386
D019287Zinc SulfateZinc Sulfate results in decreased expression of ITIH5 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030212hyaluronan metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26252352Low expression of ITIH5 in adenocarcinoma of the lung is associated with unfavorable patients' outcome. (2015)Dotsch MMEpigenetics