Gene: STARD5

80765
-
StAR related lipid transfer domain containing 5
protein-coding
15q25.1
Ensembl:ENSG00000172345 MIM:607050 Vega:OTTHUMG00000147342 UniprotKB:Q9NSY2
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.753e-1 (AD)  5.202e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERICH10.795
IFFO10.787
SEPT60.771
SEC16B0.769
APBB30.763
YEATS20.762
ESYT10.76
SERPINF10.753
GLIPR10.753
PRC10.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.457
LRAT-0.455
TSPAN12-0.402
PON3-0.394
EYA1-0.384
DIAPH3-0.38
MYOM1-0.379
ACOX2-0.376
YES1-0.373
TMEM100-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of STARD5 mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of STARD5 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of STARD5 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STARD5 mRNA21641981
D000638AmiodaroneAmiodarone results in increased expression of STARD5 mRNA19774075
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of STARD5 mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STARD5 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of STARD5 mRNA23019147
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of STARD5 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STARD5 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of STARD5 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STARD5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of STARD5 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of STARD5 mRNA26496021
D002065BuspironeBuspirone results in decreased expression of STARD5 mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of STARD5 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of STARD5 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of STARD5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of STARD5 mRNA20106945
C014347decitabine[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of STARD5 mRNA15251184
C014347decitabinedecitabine results in decreased expression of STARD5 mRNA15251184
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STARD5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STARD5 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STARD5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of STARD5 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of STARD5 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of STARD5 mRNA19467301|2501614
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of STARD5 mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STARD5 mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STARD5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STARD5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STARD5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STARD5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of STARD5 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of STARD5 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STARD5 mRNA27392435
C544151jinfukangjinfukang results in increased expression of STARD5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of STARD5 mRNA25307878
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STARD5 mRNA"18930950
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STARD5 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of STARD5 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of STARD5 mRNA"25554681|2562005
D010634PhenobarbitalPhenobarbital results in increased expression of STARD5 mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of STARD5 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of STARD5 mRNA17426115
C045950propiconazolepropiconazole results in decreased expression of STARD5 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of STARD5 mRNA24780913
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of STARD5 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of STARD5 mRNA19073995
D013749Tetrachlorodibenzodioxin[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of STARD5 mRNA15251184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STARD5 mRNA21570461|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to STARD5 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STARD5 mRNA15251184|1977048
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of STARD5 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STARD5 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STARD5 mRNA25613284
C012589trichostatin Atrichostatin A affects the expression of STARD5 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of STARD5 mRNA28973697
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STARD5 mRNA"18930950
D014520UrethaneUrethane results in increased expression of STARD5 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of STARD5 mRNA24136188
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STARD5 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of STARD5 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015485cholesterol binding-IDA18403318  
GO:0017127cholesterol transporter activity-IDA18403318  
GO:0032052bile acid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015721bile acid and bile salt transport-TAS-  
GO:0070508cholesterol import-IDA18403318  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-159418Recycling of bile acids and saltsTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24983941Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. (2014)Tang WPLoS One