Gene: CYB5B

80777
CYB5-M|CYPB5M|OMB5
cytochrome b5 type B
protein-coding
16q22.1
Ensembl:ENSG00000103018 MIM:611964 Vega:OTTHUMG00000133020 UniprotKB:O43169
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.307e-2 (AD)  6.551e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNPLA80.902
SDCBP0.89
RAB100.887
USP390.884
ADIPOR10.881
GLO10.88
SSR30.877
CNBP0.877
RPN20.875
RAB5A0.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.804
OR4F29-0.761
TRPV5-0.217
TNFRSF13B-0.19
OR6C74-0.175
CTNNA3-0.171
TSPY2-0.167
TDGF1-0.161
TCL1A-0.154
C5orf64-0.149

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYB5B mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CYB5B mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYB5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYB5B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CYB5B mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of CYB5B mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CYB5B mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYB5B mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of CYB5B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CYB5B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYB5B mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CYB5B mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYB5B mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CYB5B mRNA22378314
C053561benzamidoxime[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of benzamidoxime22924387
C053561benzamidoxime[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of benzamidoxime22924387
D019324beta-NaphthoflavoneAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYB5B mRNA]22234961
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of CYB5B mRNA22234961
D004958EstradiolEstradiol results in decreased expression of CYB5B mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of CYB5B mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of CYB5B mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CYB5B mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CYB5B mRNA25979313
C100187chloropicrinchloropicrin results in increased expression of CYB5B mRNA26352163
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CYB5B mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYB5B mRNA]17585979
D003024ClozapineClozapine results in increased expression of CYB5B mRNA19441803
C018021cobaltous chloridecobaltous chloride results in decreased expression of CYB5B mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of CYB5B mRNA24386269
D009243NAD[MARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D009243NAD[MARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CYB5B mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of CYB5B mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of CYB5B mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CYB5B mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of CYB5B mRNA19770486
C012279dibutylnitrosamine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to dibutylnitrosamine11733072
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CYB5B mRNA21266533
D002945CisplatinCisplatin results in increased expression of CYB5B mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of CYB5B mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CYB5B mRNA19850644
D004052Diethylnitrosamine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Diethylnitrosamine11733072
D004128Dimethylnitrosamine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Dimethylnitrosamine11733072
D004147DioxinsDioxins affects the expression of CYB5B mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CYB5B protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CYB5B mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CYB5B mRNA23649840
C056933fumonisin B1fumonisin B1 results in decreased expression of CYB5B mRNA16221962
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CYB5B mRNA22634610
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of CYB5B mRNA22467014
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CYB5B mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of CYB5B mRNA26191083
C410337K 7174K 7174 results in decreased expression of CYB5B mRNA24086573
C008261lead acetatelead acetate results in increased expression of CYB5B mRNA21829687
D008694MethamphetamineMethamphetamine results in increased expression of CYB5B mRNA19149911
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of CYB5B mRNA28349193
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CYB5B promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CYB5B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CYB5B mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CYB5B mRNA"20188158
C010737N(4)-hydroxycytidine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of N(4)-hydroxycytidine22924387
C010737N(4)-hydroxycytidine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of N(4)-hydroxycytidine22924387
C021202N(4)-hydroxycytosine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of N(4)-hydroxycytosine22924387
C021202N(4)-hydroxycytosine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of N(4)-hydroxycytosine22924387
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYB5B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CYB5B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYB5B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CYB5B mRNA"25554681
D009532NickelNickel results in decreased expression of CYB5B mRNA23195993
C022838nickel chloridenickel chloride results in increased expression of CYB5B mRNA24612858
C012655nimesulidenimesulide results in increased expression of CYB5B mRNA24136188
D009602Nitrosamines[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Nitrosamines11733072
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CYB5B mRNA17616710
C013161N-nitroso(di-n-propyl)amine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine11733072
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CYB5B mRNA20971185
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYB5B protein26879310
C058305phenethyl isothiocyanateCYB5B protein binds to phenethyl isothiocyanate21838287
D010634PhenobarbitalPhenobarbital results in decreased expression of CYB5B mRNA19162173
C014153pirimiphos methylpirimiphos methyl results in decreased expression of CYB5B mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of CYB5B mRNA15302862|1830175
D010894PiroxicamPiroxicam results in decreased expression of CYB5B mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of CYB5B mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of CYB5B protein23718831
D011374ProgesteroneProgesterone results in decreased expression of CYB5B mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of CYB5B mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of CYB5B mRNA18070364
D012969Sodium FluorideSodium Fluoride results in decreased expression of CYB5B protein28918527
D012999SomanSoman results in increased expression of CYB5B mRNA19281266
C059873sulfamethoxazole hydroxylamine[MARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
C059873sulfamethoxazole hydroxylamine[MARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
C025462sulindac sulfidesulindac sulfide results in decreased expression of CYB5B mRNA12734198
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of CYB5B mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYB5B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYB5B gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYB5B mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5B mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYB5B mRNA20959002
D013752TetracyclineTetracycline results in increased expression of CYB5B mRNA16917069
D019284ThapsigarginThapsigargin results in decreased expression of CYB5B mRNA22378314
C012589trichostatin Atrichostatin A results in decreased expression of CYB5B mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CYB5B mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CYB5B mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CYB5B mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of CYB5B mRNA22378314
D017974Uranium CompoundsUranium Compounds results in increased expression of CYB5B mRNA19654044
D014635Valproic AcidValproic Acid results in decreased expression of CYB5B mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CYB5B mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of CYB5B mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CYB5B gene25560391
C025643vinclozolinvinclozolin results in increased expression of CYB5B mRNA22570695
C111237vorinostatvorinostat results in increased expression of CYB5B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25616068  
GO:0020037heme binding-IDA20861021  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25189868Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (2015 Mar)Sung YJAm J Hypertens