Gene: COL18A1

80781
KNO|KNO1|KS
collagen type XVIII alpha 1 chain
protein-coding
21q22.3
Ensembl:ENSG00000182871 MIM:120328 Vega:OTTHUMG00000090407 UniprotKB:P39060
NG_011903.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.802e-1 (AD)  9.502e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL4A20.833
MYO1C0.831
TCIRG10.82
STK100.798
NBEAL20.782
NOTCH40.78
ITPR30.775
MAN2B10.774
PLEKHG20.773
CDH50.77

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.315
OR4F5-0.31
C1orf53-0.306
ABCD2-0.295
B3GALT1-0.282
SMIM18-0.276
CRH-0.274
DIAPH3-0.246
KIT-0.244
ARSF-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of COL18A1 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of COL18A1 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of COL18A1 mRNA"25710175
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of COL18A1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of COL18A1 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of COL18A1 mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of COL18A1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of COL18A1 mRNA]28655636
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of COL18A1 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of COL18A1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL18A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL18A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of COL18A1 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of COL18A1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of COL18A1 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]13679210
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]13679210
D016604Aflatoxin B1Aflatoxin B1 affects the expression of COL18A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of COL18A1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of COL18A1 mRNA19770486
C523074allylpyrocatecholallylpyrocatechol inhibits the reaction [Indomethacin results in increased expression of COL18A1 protein]18431645
D000643Ammonium ChlorideAmmonium Chloride affects the expression of COL18A1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of COL18A1 mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in decreased expression of COL18A1 mRNA16704987
D001151ArsenicArsenic affects the methylation of COL18A1 gene25304211
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of COL18A1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL18A1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL18A1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL18A1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COL18A1 mRNA20713471|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL18A1 mRNA21839799
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of COL18A1 mRNA]20404318
D004958EstradiolEstradiol results in increased expression of COL18A1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of COL18A1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of COL18A1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of COL18A1 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of COL18A1 mRNA18958704
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of COL18A1 mRNA19925653
C018475butyraldehydebutyraldehyde results in decreased expression of COL18A1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of COL18A1 mRNA22110744
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in increased expression of COL18A1 protein20433813
D002118CalciumCOL18A1 protein affects the abundance of Calcium15296943
D002211CapsaicinCapsaicin results in increased expression of COL18A1 mRNA21310942
D002220CarbamazepineCarbamazepine affects the expression of COL18A1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of COL18A1 protein17574579
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of COL18A1 mRNA27339419
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA27344345
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of COL18A1 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of COL18A1 mRNA27344345
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of COL18A1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of COL18A1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of COL18A1 mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of COL18A1 mRNA17602206
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]13679210
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]13679210
C018021cobaltous chloridecobaltous chloride results in decreased expression of COL18A1 mRNA13679210
C018021cobaltous chloridecobaltous chloride results in decreased expression of COL18A1 protein13679210
C018021cobaltous chloride[cobaltous chloride results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of COL18A1 mRNA13679210
C018021cobaltous chloridewortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]13679210
C018021cobaltous chloridewortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]13679210
C018021cobaltous chloridecobaltous chloride results in decreased expression of COL18A1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of COL18A1 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of COL18A1 mRNA19789285
D003471CuprizoneCuprizone results in increased expression of COL18A1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of COL18A1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased methylation of COL18A1 promoter27989131
D003561CytarabineCytarabine results in decreased expression of COL18A1 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of COL18A1 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of COL18A1 mRNA27392435
D004026DieldrinDieldrin affects the expression of COL18A1 mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of COL18A1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of COL18A1 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL18A1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of COL18A1 mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of COL18A1 mRNA19638242
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of COL18A1 mRNA27638505
D004147DioxinsDioxins affects the expression of COL18A1 mRNA20463971
D004317DoxorubicinCOL18A1 protein promotes the reaction [Doxorubicin results in decreased expression of VEGFA protein]17627616
D004317DoxorubicinDoxorubicin results in increased expression of COL18A1 mRNA15033991
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of COL18A1 mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of COL18A1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL18A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of COL18A1 mRNA17557909
D005419FlavonoidsFlavonoids results in increased expression of COL18A1 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of COL18A1 mRNA24136188
C056933fumonisin B1fumonisin B1 results in decreased expression of COL18A1 mRNA16221962
D005665FurosemideFurosemide results in decreased expression of COL18A1 mRNA16526316
D019833GenisteinGenistein results in decreased expression of COL18A1 mRNA16705744
D019833GenisteinGenistein results in increased expression of COL18A1 mRNA20884965
D005897GlafenineGlafenine results in increased expression of COL18A1 mRNA24136188
D006493HeparinHeparin binds to COL18A1 protein alternative form15604266
D017313FenretinideFenretinide results in decreased expression of COL18A1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of COL18A1 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of COL18A1 mRNA28628672
D007213Indomethacinallylpyrocatechol inhibits the reaction [Indomethacin results in increased expression of COL18A1 protein]18431645
D007213IndomethacinIndomethacin results in increased expression of COL18A1 protein18431645
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of COL18A1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL18A1 mRNA26752646
C008261lead acetatelead acetate results in decreased expression of COL18A1 mRNA11578147
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of COL18A1 mRNA26378955
C025340manganese chloridemanganese chloride results in increased expression of COL18A1 mRNA17467022
D008627Mercuric ChlorideMercuric Chloride affects the expression of COL18A1 mRNA20353558
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of COL18A1 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of COL18A1 protein26558463
C523799MRK 003COL18A1 results in increased susceptibility to MRK 00319903844
C568376MT19c compoundMT19c compound results in decreased expression of COL18A1 mRNA21781307
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of COL18A1 mRNA"25461557
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of COL18A1 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of COL18A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of COL18A1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of COL18A1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of COL18A1 mRNA18978301
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of COL18A1 mRNA27344345
C051752nefazodonenefazodone results in decreased expression of COL18A1 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of COL18A1 mRNA22546817
C012655nimesulidenimesulide results in decreased expression of COL18A1 mRNA24136188
D010100OxygenOxygen deficiency results in increased expression of COL18A1 mRNA13679210
D010100OxygenSB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of COL18A1 mRNA]13679210
D010100OxygenOxygen deficiency results in increased expression of COL18A1 mRNA24205000
D017239PaclitaxelPaclitaxel results in increased expression of COL18A1 mRNA19682730
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of COL18A1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of COL18A1 mRNA28655636
C410127PCB 180PCB 180 results in increased expression of COL18A1 mRNA23829299
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of COL18A1 protein26879310
D010656PhenylephrinePhenylephrine results in decreased expression of COL18A1 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL18A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of COL18A1 mRNA26272509
D010672PhenytoinPhenytoin results in decreased expression of COL18A1 mRNA14741686
D010758PhosphorusCOL18A1 protein affects the abundance of Phosphorus15296943
C014153pirimiphos methylpirimiphos methyl results in increased expression of COL18A1 mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of COL18A1 mRNA16221962|1742611
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of COL18A1 mRNA]20059764
C006253pirinixic acidpirinixic acid results in decreased expression of COL18A1 mRNA16940010
D010936Plant ExtractsPlant Extracts results in decreased expression of COL18A1 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of COL18A1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of COL18A1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of COL18A1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of COL18A1 mRNA21632981
D017382Reactive Oxygen Species[cobaltous chloride results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of COL18A1 mRNA13679210
C059514resveratrolresveratrol results in decreased expression of COL18A1 mRNA23224687
C093642SB 203580SB 203580 inhibits the reaction [Oxygen deficiency results in increased expression of COL18A1 mRNA]13679210
C093642SB 203580SB 203580 results in decreased expression of COL18A1 mRNA13679210
D012643SeleniumSelenium results in increased expression of COL18A1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of COL18A1 protein25895662
D012834SilverSilver results in increased expression of COL18A1 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of COL18A1 gene28589171
C016104sodium bichromatesodium bichromate affects the expression of COL18A1 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in decreased expression of COL18A1 protein28918527
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of COL18A1 mRNA26378955
C446685systhane"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of COL18A1 mRNA"25461557
D013629TamoxifenTamoxifen affects the expression of COL18A1 mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of COL18A1 mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL18A1 mRNA21296121|2791314
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL18A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL18A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COL18A1 mRNA16120747|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL18A1 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COL18A1 mRNA18796159|2121527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL18A1 mRNA27913140
D013893ThiramThiram results in decreased expression of COL18A1 mRNA20530235
D013988TiclopidineTiclopidine results in increased expression of COL18A1 protein11353854
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of COL18A1 mRNA23825117
C009495titanium dioxidetitanium dioxide results in increased expression of COL18A1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COL18A1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of COL18A1 mRNA23724009
C034613triacsin Ctriacsin C results in decreased expression of COL18A1 mRNA16704987
C011559tributyltintributyltin results in decreased expression of COL18A1 mRNA29191790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of COL18A1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of COL18A1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of COL18A1 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of COL18A1 mRNA17569031
D014635Valproic AcidValproic Acid results in decreased expression of COL18A1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of COL18A1 mRNA23179753|2718838
D014640VancomycinVancomycin results in decreased expression of COL18A1 mRNA18930951
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of COL18A1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of COL18A1 mRNA28655636
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of COL18A1 mRNA23825117
D014800VitalliumVitallium analog results in increased expression of COL18A1 mRNA23825117
D014810Vitamin EVitamin E results in increased expression of COL18A1 mRNA19244175
C009687wortmanninwortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]13679210
C009687wortmanninwortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]13679210
D015032ZincZinc deficiency results in increased expression of COL18A1 mRNA22171008
C088658zoledronic acidzoledronic acid results in decreased expression of COL18A1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0030020extracellular matrix structural constituent conferring tensile strength-HDA20551380  27559042  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001886endothelial cell morphogenesis-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007601visual perception-TAS10942434  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008285negative regulation of cell proliferation-TAS9008168  
GO:0009887animal organ morphogenesis-TAS10942434  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0042493response to drug-IEA-  
GO:0051599response to hydrostatic pressure-IEA-  
GO:2000353positive regulation of endothelial cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005604basement membrane-IEA-  
GO:0005615extracellular space-HDA20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-HDA23658023  
GO:0062023collagen-containing extracellular matrix-HDA23979707  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withTAS22261194  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000157Laminin interactionsTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20346360Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (2010 Jul)Roberts KEGastroenterology