Gene: SSPN

8082
DAGA5|KRAG|NSPN|SPN1|SPN2
sarcospan
protein-coding
12p12.1
Ensembl:ENSG00000123096 MIM:601599 Vega:OTTHUMG00000169167 UniprotKB:Q14714
NG_012011.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.489e-1 (AD)  8.075e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERLIN20.862
RANBP3L0.852
ATP13A40.851
PIK3C2A0.838
P2RY10.832
CYBRD10.83
GOLIM40.83
NOTCH20.827
PREX20.821
IL17RD0.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
F12-0.411
LAMB3-0.411
GALNT14-0.404
MIP-0.403
GNB1L-0.383
GPR68-0.382
RHO-0.377
LIPH-0.373
CACNA1F-0.37
TNFRSF18-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SSPN mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SSPN mRNA"21354444
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SSPN mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SSPN mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of SSPN mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SSPN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SSPN mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SSPN mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SSPN mRNA24449571
C487081belinostatbelinostat results in decreased expression of SSPN mRNA27188386
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SSPN mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SSPN mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SSPN mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SSPN mRNA19770486
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA]25566086
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SSPN mRNA20660070
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSPN mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSPN mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SSPN mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSPN mRNA28628672
C584509C646 compoundC646 compound results in increased expression of SSPN mRNA26191083
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNA12634122
D002220CarbamazepineCarbamazepine affects the expression of SSPN mRNA25979313
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNA12634122
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SSPN mRNA27858113
C031180chrysenechrysene results in increased expression of SSPN mRNA26377693
D002994ClofibrateClofibrate results in increased expression of SSPN mRNA17585979
D003471CuprizoneCuprizone results in increased expression of SSPN mRNA27523638
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SSPN mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSPN mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSPN mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSPN mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SSPN mRNA21266533
D002117CalcitriolCalcitriol results in decreased expression of SSPN mRNA26485663
D004237DiuronDiuron results in decreased expression of SSPN mRNA25152437
D004237DiuronDiuron results in increased expression of SSPN mRNA21551480
D004397FonofosFonofos results in increased methylation of SSPN promoter22847954
D017313FenretinideFenretinide results in decreased expression of SSPN mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SSPN mRNA17183730
C492448ICG 001ICG 001 results in increased expression of SSPN mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSPN mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSPN mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSPN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSPN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SSPN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SSPN mRNA28628672
D007854LeadLead results in increased expression of SSPN mRNA19921347
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNA12634122
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SSPN mRNA"26251327
C523799MRK 003MRK 003 results in decreased expression of SSPN mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SSPN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SSPN mRNA"25554681
D009532NickelNickel results in decreased expression of SSPN mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SSPN mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SSPN mRNA25729387
D010278ParathionParathion results in increased methylation of SSPN promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SSPN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SSPN mRNA26272509
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SSPN mRNA20660070
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SSPN mRNA27029645
D012402RotenoneRotenone results in decreased expression of SSPN mRNA27979718
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of SSPN mRNA28595984
D018038Sodium SeleniteSodium Selenite results in decreased expression of SSPN mRNA18175754
C012568terbufosterbufos results in increased methylation of SSPN promoter22847954
C004648testosterone enanthatetestosterone enanthate affects the expression of SSPN mRNA17440010
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SSPN mRNA25729387
D014212TretinoinTretinoin results in increased expression of SSPN mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of SSPN mRNA24935251
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SSPN mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of SSPN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SSPN mRNA23179753|2493525
D014638VanadatesVanadates results in increased expression of SSPN mRNA22714537
C025643vinclozolinvinclozolin affects the expression of SSPN mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of SSPN mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS9395445  
GO:0007155cell adhesion-TAS9395445  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IEA-  
GO:0016010dystrophin-associated glycoprotein complex-IEA-  
GO:0030054cell junction-IEA-  
GO:0030133transport vesicle-IDA-  
GO:0042383sarcolemma-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes